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Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression

The aggregation of intracellular tau protein is a major hallmark of Alzheimer’s disease (AD). The extent and the stereotypical spread of tau pathology in the AD brain are correlated with cognitive decline during disease progression. Here we present an in-depth analysis of endogenous tau fragmentation in a well-characterized cohort of AD and age-matched control subjects. Using...

Robert Kellner Lecture awarded to ABC author Jürgen Popp

Andrea Pfeifer 0 1 0 Professor Jrgen Popp is the recipient of the 2013 Robert Kellner Lecture Award. His lecture, entitled The many facets of Raman spectroscopy for biomedical analysis, will be ... himself to Andrea Pfeifer. What is the focus of your award-winning research and what was/is your motivation? - routine diagnostics. In other words, my great motivation is to move biophotonics technologies

Meet the Editors of an Outstanding Journal — An interview

Andrea Pfeifer 0 ) Analytical and Bioanalytical Chemistry , Springer, Tiergartenstr. 17, 69121 Heidelberg, Germany Each of you is an established and renowned scientist, and as a group you cover

Oluwatosin O. Dada wins ABC best paper award

Andrea Pfeifer 0 0 Oluwatosin O. Dada received his Bachelor degree in Industrial Chemistry in 2001 from Olabisi Onabanjo University, Nigeria . He moved to the United States in 2004 , where he ... . Dada talks about his research, his motivations, and about himself to Andrea Pfeifer. What was your motivation to perform research into high-throughput capillary isoelectric focusing? Capillary

Andreas Römpp and Sabine Guenther win the ABC Best Paper Award

talk about their research, their motivations, and about themselves to Nicola Oberbeckmann-Winter and Andrea Pfeifer. What was your motivation to do research in the area of mass spectrometry imaging? A

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

, Jasvinder K. Atwal, Ryan J. Watts & Weiru WangAC Immune SA, EPFL Innovation Park, Building B, 1015 Lausanne, SwitzerlandOskar Adolfsson, Andreas Muhs, Andrea Pfeifer & Maria Pihlgren AuthorsSearch for Mark ... journals • PubMed • Google ScholarSearch for Andrea Pfeifer in:Nature Research journals • PubMed • Google ScholarSearch for Maria Pihlgren in:Nature Research journals • PubMed • Google ScholarSearch for

Engineering Amyloid-Like Assemblies from Unstructured Peptides via Site-Specific Lipid Conjugation

: The authors Mara Pilar Lo pez Deber, David T. Hickman, Andrea Pfeifer, and Andreas Muhs are paid employees and owners of shares of the company AC Immune S.A. This does not alter the authors adherence to

Jean-Philippe Frimat wins ABC Best Paper Award

Andrea Pfeifer 0 1 0 Jean-Philippe Frimat completed his undergraduate diploma at The University of Edinburgh in Medical Microbiology (BSc Hons) in 2004 and obtained his MSc from The University of ... =10.1007%2fs00216-009-2824-7. Jean-Phillippe Frimat talks about his research, his motivations and about himself to Andrea Pfeifer. What is your motivation to do research combining cell analysis and

An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome

In Down syndrome (DS) or trisomy of chromosome 21, the β-amyloid (Aβ) peptide product of the amyloid precursor protein (APP) is present in excess. Evidence points to increased APP gene dose and Aβ as playing a critical role in cognitive difficulties experienced by people with DS. Particularly, Aβ is linked to the late-life emergence of dementia as associated with...

Development of a Small D-Enantiomeric Alzheimer’s Amyloid-β Binding Peptide Ligand for Future In Vivo Imaging Applications

Alzheimer’s disease (AD) is a devastating disease affecting predominantly the aging population. One of the characteristic pathological hallmarks of AD are neuritic plaques, consisting of amyloid-β peptide (Aβ). While there has been some advancement in diagnostic classification of AD patients according to their clinical severity, no fully reliable method for pre-symptomatic...

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

. Hickman, Oskar Adolfsson, Nathalie Chuard, Dorin Mlaki Ndao, Andrea Pfeifer and Andreas Muhs are employees of ACImmune, Lausanne, Switzerland. This study was partly funded by ACImmune. There are no patents

Cytochrome P450 expression and related metabolism in human buccal mucosa

Constituents in food and fluids, tobacco chemicals and many drugs are candidates for oral absorption and oxidative metabolism. On this basis, the expression of cytochrome P450 isozymes (CYPs) and the conversion of CYP substrates were analysed in reference to buccal mucosa. A RT–PCR based analysis of human buccal tissue from 13 individuals demonstrated consistent expression of...