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Search: authors:"Andrew A. Beharry"

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Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells

. Funding acquisition: Leona D. Samson. Investigation: Zachary D. Nagel, Andrew A. Beharry, Patrizia Mazzucato, Gaspar J. Kitange. Methodology: Zachary D. Nagel, Andrew A. Beharry, Leona D. Samson ... . Resources: Andrew A. Beharry. Supervision: Jann N. Sarkaria, Eric T. Kool, Leona D. Samson. Writing ? original draft: Zachary D. Nagel, Leona D. Samson. Writing ? review & editing: Zachary D. Nagel, Andrew

Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response

Common alkylating antitumor drugs, such as temozolomide, trigger their cytotoxicity by methylating the O6-position of guanosine in DNA. However, the therapeutic effect of these drugs is dampened by elevated levels of the DNA repair enzyme, O6-methylguanine DNA methyltransferase (MGMT), which directly reverses this alkylation. As a result, assessing MGMT levels in patient samples...