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A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk

and Subsequent Breast Cancer Risk Geoffrey C. Kabat,1 Rita A. Kandel,2 Andrew G. Glass,3 Joan G. Jones,4 Neal Olson,3 Catherine Duggan,5 Mindy Ginsberg,1 Abdissa Negassa,1 and Thomas E. Rohan1

A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk

Mutations in the p53 tumor suppressor gene and accumulation of its protein in breast tissue are thought to play a role in breast carcinogenesis. However, few studies have prospectively investigated the association of p53 immunopositivity and/or p53 alterations in women with benign breast disease in relation to the subsequent risk of invasive breast cancer. We carried out a case...