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E-mail Communication in the Management of Gastroenterology Patients: A Review

. ACKnoWLEDGEmEntS: Dr Ian Plener was the 2010 Ilona Diener Clinical Summer Student in Inflammatory Bowel Disease. Dr Andrew Hayward was the 2005 Ilona Diener Clinical Summer Student in Inflammatory Bowel Disease

DotMapper: an open source tool for creating interactive disease point maps

Background Molecular strain typing of tuberculosis isolates has led to increased understanding of the epidemiological characteristics of the disease and improvements in its control, diagnosis and treatment. However, molecular cluster investigations, which aim to detect previously unidentified cases, remain challenging. Interactive dot mapping is a simple approach which could aid...

A high HIV-1 strain variability in London, UK, revealed by full-genome analysis: Results from the ICONIC project

foundation Trust) and Prof A.J. Leigh Brown (University of Edinburgh). Author Contributions Conceptualization: Gonzalo Yebra, Dan Frampton, Zisis Kozlakidis, Andrew Hayward, Paul Kellam, Andrew J. Leigh ... Brown. Data curation: Jade Raffle, Jonathan Hubb, R. Bridget Ferns, Laura Waters, Zisis Kozlakidis, Andrew Hayward, Paul Kellam, Deenan Pillay, Duncan Clark, Eleni Nastouli. Formal analysis: Gonzalo

National observational study to evaluate the “cleanyourhands” campaign (NOSEC): a questionnaire based study of national implementation

Introduction The number of national hand-hygiene campaigns has increased recently, following the World Health Organisation’s (WHO) “Save Lives: clean your hands” initiative (2009), which offers hospitals a multi-component hand-hygiene intervention. The number of campaigns to be evaluated remains small. Most evaluations focus on consumption of alcohol hand rub (AHR). We are not...

Networking for infectious disease

Michael Head and colleagues describe how the Infectious Disease Research Network can help microbiologists in the United Kingdom to collaborate more effectively.

The Feedback Intervention Trial (FIT) — Improving Hand-Hygiene Compliance in UK Healthcare Workers: A Stepped Wedge Cluster Randomised Controlled Trial

Introduction Achieving a sustained improvement in hand-hygiene compliance is the WHO’s first global patient safety challenge. There is no RCT evidence showing how to do this. Systematic reviews suggest feedback is most effective and call for long term well designed RCTs, applying behavioural theory to intervention design to optimise effectiveness. Methods Three year stepped wedge...

Is public transport a risk factor for acute respiratory infection?

Background The relationship between public transport use and acquisition of acute respiratory infection (ARI) is not well understood but potentially important during epidemics and pandemics. Methods A case-control study performed during the 2008/09 influenza season. Cases (n = 72) consulted a General Practitioner with ARI, and controls with another non-respiratory acute condition...

Circulating Influenza Virus, Climatic Factors, and Acute Myocardial Infarction: A Time Series Study in England and Wales and Hong Kong

(See the editorial commentary by Finelli and Chaves, on pages 1701-4.) Background. Previous studies identifying associations between influenza and acute cardiac events may have been confounded by climatic factors. Differing seasonal patterns of influenza activity in Hong Kong and England and Wales provide a natural experiment to examine associations with myocardial infarction (MI...

Guillain-Barré Syndrome and Preceding Infection with Campylobacter, Influenza and Epstein-Barr Virus in the General Practice Research Database

BackgroundA number of infectious agents have previously been suggested as risk factors for the development of Guillain-Barré syndrome (GBS), but robust epidemiologic evidence for these associations is lacking.Methods and FindingsWe conducted a nested case-control study using data from the United Kingdom General Practice Research Database between 1991 and 2001. Controls were...

Use of a Human Influenza Challenge Model to Assess Person-to-Person Transmission: Proof-of-Concept Study

Background. Influenza transmission in humans remains poorly understood. In particular, the relative contribution of contact, large droplet, and aerosol transmission is unknown. The aims of this proof-of-concept study were to determine whether an experimentally induced influenza infection is transmissible between humans and whether this would form a viable platform for future...

Incidence of Guillain-Barré Syndrome among Patients with Campylobacter Infection: A General Practice Research Database Study

The association between Campylobacter infection and subsequent Guillain-Barré syndrome (GBS) has been well documented. To date, however, there exists no direct estimate of the incidence of GBS among patients with Campylobacter infection. Using the General Practice Research Database, we estimate the incidence of GBS in a cohort of patients presenting with Campylobacter enteritis...