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13 papers found.
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Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons

Stretch-activated afferent neurons, such as those of mammalian muscle spindles, are essential for proprioception and motor co-ordination, but the underlying mechanisms of mechanotransduction are poorly understood. The dorsal bipolar dendritic (dbd) sensory neurons are putative stretch receptors in the Drosophila larval body wall. We have developed an in vivo protocol to obtain...

Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation

Lina Ma 0 Andrew P. Jarman () 0 0 Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh , George Square, Edinburgh EH8 9XD , UK Summary A significant number of

The function and regulation of the bHLH gene, cato, in Drosophila neurogenesis

Background bHLH transcription factors play many roles in neural development. cousin of atonal (cato) encodes one such factor that is expressed widely in the developing sensory nervous system of Drosophila. However, nothing definitive was known of its function owing to the lack of specific mutations. Results We characterised the expression pattern of cato in detail using newly...

Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes

Defects in cilium and centrosome function result in a spectrum of clinically-related disorders, known as ciliopathies. However, the complex molecular composition of these structures confounds functional dissection of what any individual gene product is doing under normal and disease conditions. As part of an siRNA screen for genes involved in mammalian ciliogenesis, we and others...

Merged consensus clustering to assess and improve class discovery with microarray data

Background One of the most commonly performed tasks when analysing high throughput gene expression data is to use clustering methods to classify the data into groups. There are a large number of methods available to perform clustering, but it is often unclear which method is best suited to the data and how to quantify the quality of the classifications produced. Results Here we...

Bio::Homology::InterologWalk - A Perl module to build putative protein-protein interaction networks through interolog mapping

Background Protein-protein interaction (PPI) data are widely used to generate network models that aim to describe the relationships between proteins in biological systems. The fidelity and completeness of such networks is primarily limited by the paucity of protein interaction information and by the restriction of most of these data to just a few widely studied experimental...

Live imaging of Drosophila gonad formation reveals roles for Six4 in regulating germline and somatic cell migration

Background Movement of cells, either as amoeboid individuals or in organised groups, is a key feature of organ formation. Both modes of migration occur during Drosophila embryonic gonad development, which therefore provides a paradigm for understanding the contribution of these processes to organ morphogenesis. Gonads of Drosophila are formed from three distinct cell types...

Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos

Background The regulation of proneural gene expression is an important aspect of neurogenesis. In the study of the Drosophila proneural genes, scute and atonal, several themes have emerged that contribute to our understanding of the mechanism of neurogenesis. First, spatial complexity in proneural expression results from regulation by arrays of enhancer elements. Secondly...

The Gene Regulatory Cascade Linking Proneural Specification with Differentiation in Drosophila Sensory Neurons

J. Douglas Armstrong 0 Andrew P. Jarman 0 Matthew P. Scott, Stanford University, United States of America 0 Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh

HEATR2 Plays a Conserved Role in Assembly of the Ciliary Motile Apparatus

. Yeyati David T. Bonthron Ian M. Carr Bruce Hayward Alexander F. Markham Jilly E. Hope Alex von Kriegsheim Hannah M. Mitchison Ian J. Jackson Be ne dicte Durand Walter Reith Eamonn Sheridan Andrew P. Jarman

Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups

Emma L. Rawlins 0 Neil M. White 0 Andrew P. Jarman ) 0 0 Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh , King's Buildings, Edinburgh EH9 3JR