Advanced search    

Search: authors:"Angela Sciacqua"

19 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Association between hemoglobin glycation index with insulin resistance and carotid atherosclerosis in non-diabetic individuals

Hemoglobin glycation index (HGI), defined as the difference between the observed HbA1c value and the value of HbA1c predicted from plasma glucose levels, represents a measure of the degree of non-enzymatic glycation of hemoglobin and it has been found to be positively associated with micro- and macro-vascular complications in subjects with type 2 diabetes. To investigate the...

Association between Noninvasive Fibrosis Markers and Cardio-Vascular Organ Damage among Adults with Hepatic Steatosis

Evidence suggests that advanced fibrosis, as determined by the noninvasive NAFLD fibrosis score (NFS), is a predictor of cardiovascular mortality in individuals with ultrasonography-diagnosed NAFLD. Whether the severity of histology (i.e., fibrosis stage) is associated with more pronounced cardiovascular organ damage is unsettled. In this study, we analyzed the clinical utility...

Association between Noninvasive Fibrosis Markers and Chronic Kidney Disease among Adults with Nonalcoholic Fatty Liver Disease

Angela Sciacqua 0 Claudia Miele, Consiglio Nazionale delle Ricerche, Italy 0 Department of Medical and Surgical Sciences, University ''Magna Graecia'' of Catanzaro , Catanzaro , Italy Evidence suggests

Low dose of acetylsalicylic acid and oxidative stress-mediated endothelial dysfunction in diabetes: a short-term evaluation

in the restenosis after percutaneous coronary intervention. Conflict of interest Eliezer Joseph Tassone, Maria Perticone, Angela Sciacqua, Simona Fortunata Mafrici, Chiara Settino, Natalia Malara

Association of Insulin Resistance Indexes to Carotid Intima–Media Thickness

Objectives Accumulating evidence suggests an association between insulin resistance (IR) and cardiovascular diseases The aim of this study was to examine the relationship between indexes of IR and common carotid intima–media thickness (IMT), an indicator of vascular damage. Methods In 847 non-diabetic Caucasians a 75 g oral glucose tolerance test was performed and surrogate...

Vitamin D and 1-hour post-load plasma glucose in hypertensive patients

Background A plasma glucose value ≥155 mg/dl for 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify subjects with normal glucose tolerance (NGT) at high-risk for type-2 diabetes and with subclinical organ damage. We designed this study to address if 25-hydroxyvitamin D [25(OH)D] circulating levels are associated with glucose tolerance...

Decreased Insulin Clearance in Individuals with Elevated 1-h Post-Load Plasma Glucose Levels

Reduced insulin clearance has been shown to predict the development of type 2 diabetes. Recently, it has been suggested that plasma glucose concentrations ≥8.6 mmol/l (155 mg/dl) at 1 h during an oral glucose tolerance test (OGTT) can identify individuals at high risk for type 2 diabetes among those who have normal glucose tolerance (NGT 1 h-high). The aim of this study was to...

Serum Uric Acid and 1-h Postload Glucose in Essential Hypertension

FRANCESCO PERTICONE ANGELA SCIACQUA MARIA PERTICONE FRANCO ARTURI PAOLA ELISA SCARPINO MICHELE QUERO GIORGIO SESTI C a r d i o v a s c u l a r a n d OBJECTIVEdSubjects who are normal glucose

Association between One-Hour Post-Load Plasma Glucose Levels and Vascular Stiffness in Essential Hypertension

Objectives Pulse wave velocity (PWV) is a surrogate end-point for cardiovascular morbidity and mortality. A plasma glucose value ≥155 mg/dl for the 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify subjects with normal glucose tolerance (NGT) at high-risk for type-2 diabetes (T2D) and for subclinical organ damage. Thus, we addressed...

One-Hour Postload Plasma Glucose Levels and Left Ventricular Mass in Hypertensive Patients

ANGELA SCIACQUA SOFIA MICELI GIUSEPPE CARULLO LAURA GRECO ELENA SUCCURRO FRANCO ARTURI GIORGIO SESTI FRANCESCO PERTICONE C a r d i o v a s c u l a r OBJECTIVE-Left ventricular hypertrophy (LVH), an

Cardiometabolic Risk Profiles and Carotid Atherosclerosis in Individuals With Prediabetes Identified by Fasting Glucose, Postchallenge Glucose, and Hemoglobin A1c Criteria

MARIA A. MARINI ELENA SUCCURRO ERSILIA CASTALDO SABRINA CUFONE FRANCO ARTURI PHD ANGELA SCIACQUA RENATO LAURO MARTA L. HRIBAL PHD FRANCESCO PERTICONE GIORGIO SESTI C a r d i o v a s c u l a r a n d

Insulin Sensitivity, β-Cell Function, and Incretin Effect in Individuals With Elevated 1-Hour Postload Plasma Glucose Levels

MARIA A. MARINI ELENA SUCCURRO SIMONA FRONTONI SIMONA MASTROIANNI FRANCO ARTURI PHD ANGELA SCIACQUA RENATO LAURO MARTA L. HRIBAL PHD FRANCESCO PERTICONE GIORGIO SESTI C a r d i o v a s c u l a r

One-Hour Postload Plasma Glucose Levels and Diastolic Function in Hypertensive Patients

ANGELA SCIACQUA SOFIA MICELI LAURA GRECO FRANCO ARTURI PAOLA NACCARATO DEBORAH MAZZAFERRO ELIEZER J. TASSONE LAURA TURANO FRANCESCO MARTINO GIORGIO SESTI FRANCESCO PERTICONE C a r d i o v a s c u l

A Functional Variant of the Dimethylarginine Dimethylaminohydrolase-2 Gene Is Associated with Insulin Sensitivity

Background Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase, which was associated with insulin resistance. Dimethylarginine dimethylaminohydrolase (DDAH) is the major determinant of plasma ADMA. Examining data from the DIAGRAM+ (Diabetes Genetics Replication And Meta-analysis), we identified a variant (rs9267551) in the DDAH2 gene...

Endothelial Dysfunction and C-Reactive Protein Are Risk Factors for Diabetes in Essential Hypertension

OBJECTIVE—Type 2 diabetes and essential hypertension are major risk factors for cardiovascular diseases. Endothelial dysfunction is an early step in the development of atherosclerosis and has been demonstrated in hypertensive and diabetic patients. RESEARCH DESIGN AND METHODS—We designed this study to determine whether forearm endothelial dysfunction is an independent predictor...

Weight Loss in Combination With Physical Activity Improves Endothelial Dysfunction in Human Obesity

OBJECTIVE—To test whether weight loss may improve endothelial dysfunction in human obesity, we recruited 28 healthy obese subjects, aged 30–46 years, with BMI 30–43 kg/m2. RESEARCH DESIGN AND METHODS—Endothelium-dependent and -independent vasodilation were investigated by intra-arterial infusion of increasing doses of acetylcholine (ACh; 7.5, 15, and 30 μg · ml−1 · min−1) and...

Plasma Concentration of IGF-I Is Independently Associated With Insulin Sensitivity in Subjects With Different Degrees of Glucose Tolerance

OBJECTIVE—We studied the relationships between plasma IGF-I concentrations and insulin sensitivity in subjects with various degrees of glucose tolerance. RESEARCH DESIGN AND METHODS—A total of 357 nondiabetic subjects, 54 subjects with impaired glucose tolerance and 98 newly diagnosed type 2 diabetic subjects, were consecutively recruited, and anthropometric and biochemical...

The Arg972 Variant in Insulin Receptor Substrate-1 Is Associated With an Increased Risk of Secondary Failure to Sulfonylurea in Patients With Type 2 Diabetes

OBJECTIVE—The aim of this study was to investigate whether diabetic patients carrying the Arg972 insulin receptor substrate-1 (IRS-1) variant are at increased risk for secondary failure to sulfonylurea. RESEARCH DESIGN AND METHODS—A total of 477 unrelated Caucasian type 2 diabetic patients were recruited according to the following criteria: onset of diabetes after age 35 years...

The −866A/A Genotype in the Promoter of the Human Uncoupling Protein 2 Gene Is Associated With Insulin Resistance and Increased Risk of Type 2 Diabetes

Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane carriers that uncouple pro-ton entry in the mitochondrial matrix from ATP synthesis. The −866G/A polymorphism in the UCP2 gene, which enhances its transcriptional activity, was associated with enhanced risk for type 2 diabetes in obese subjects. We addressed the question of whether the −866G/A polymorphism...