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Decreasing Delirium through Music (DDM) in critically ill, mechanically ventilated patients in the intensive care unit: study protocol for a pilot randomized controlled trial

Delirium is a highly prevalent and morbid syndrome in intensive care units (ICUs). Changing the stressful environment within the ICU via music may be an effective and a scalable way to reduce the burden of delirium. The Decreasing Delirium through Music (DDM) study is a three-arm, single-blind, randomized controlled feasibility trial. Sixty patients admitted to the ICU with...

Response to depression treatment in the Aging Brain Care Medical Home model

Response to depression treatment in the Aging Brain Care Medical Home model Michael A LaMantia,1–4 Anthony J Perkins,5,6 Sujuan Gao,2,7 Mary G Austrom,8,9 Cathy A Alder,10 Dustin D French,11,12 Debra

Older Primary Care Patients’ Attitudes and Willingness to Screen for Dementia

Objective. To understand older primary care patients’ perceptions of the risks and benefits of dementia screening and to measure the association between attitudes and screening behaviors. Methods. Eligible patients completed the Perceptions Regarding Investigational Screening for Memory in Primary Care (PRISM-PC) questionnaire and then were asked to undergo dementia screening by...

Older Primary Care Patients’ Attitudes and Willingness to Screen for Dementia

Objective. To understand older primary care patients’ perceptions of the risks and benefits of dementia screening and to measure the association between attitudes and screening behaviors. Methods. Eligible patients completed the Perceptions Regarding Investigational Screening for Memory in Primary Care (PRISM-PC) questionnaire and then were asked to undergo dementia screening by...

The Indiana University Cognitive Health Outcomes Investigation of the Comparative Effectiveness of dementia screening (CHOICE) study: study protocol for a randomized controlled trial

Fowler fowlernr@upmc.edu 0 Amanda Harrawood Amie Frame Anthony J Perkins Sujuan Gao Christopher M Callahan Greg A Sachs Dustin D French Malaz A Boustani 0 Department of Medicine, University of Pittsburgh

Medication adherence and tolerability of Alzheimer’s disease medications: study protocol for a randomized controlled trial

Background The class of acetylcholinesterase inhibitors (ChEI), including donepezil, rivastigmine, and galantamine, have similar efficacy profiles in patients with mild to moderate Alzheimer’s disease (AD). However, few studies have evaluated adherence to these agents. We sought to prospectively capture the rates and reasons for nonadherence to ChEI and determine factors...

Practical clinical tool to monitor dementia symptoms: the HABC-Monitor

Practical clinical tool to monitor dementia symptoms: the HABC-Monitor Patrick O Monahan,1 Malaz A Boustani,1–3,6 Catherine Alder,2,3,6 James E Galvin,7 Anthony J Perkins,2,3 Patrick Healey,4 Azita

Acute Care Utilization by Dementia Caregivers Within Urban Primary Care Practices

BACKGROUNDCaring for an individual with Alzheimer’s dementia (AD) is stressful, and studies show that this stress has an impact on both the physical and mental health of the caregiver. However, many questions remain about the characteristics of AD patients and their caregivers that contribute to this stress and how it impacts caregivers’ use of healthcare resources.OBJECTIVETo...

Improving delirium care in the intensive care unit: The design of a pragmatic study

Background Delirium prevalence in the intensive care unit (ICU) is high. Numerous psychotropic agents are used to manage delirium in the ICU with limited data regarding their efficacy or harms. Methods/Design This is a randomized controlled trial of 428 patients aged 18 and older suffering from delirium and admitted to the ICU of Wishard Memorial Hospital in Indianapolis...

Association of Antioxidants with Memory in a Multiethnic Elderly Sample Using the Third National Health and Nutrition Examination Survey

Pharmacology and Toxicology, Indiana University , Indianapolis , IN. Reprint requests to Mr. Anthony J. Perkins, Regenstrief Institute for Health Care , 1001 W. 10th St., RG6, Indianapolis, IN 46202 5 Division