Advanced search    

Search: authors:"Antoine Kimmoun"

11 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Effects of low doses of esmolol on cardiac and vascular function in experimental septic shock

Background Administration of a selective β1-blocker, such as esmolol, in human septic shock has demonstrated cardiovascular protective effects related to heart rate reduction. Certain experimental data also indicate that esmolol exerts systemic anti-inflammatory and beneficial effects on vascular tone. Thus, the present study aimed to determine whether a non-chronotropic dose of...

Angiotensin II: a new approach for refractory shock management?

Patients with distributive shock still have a high mortality rate and remain an important issue for intensivists. Management of catecholamine-resistant shock in these patients poses a challenging problem. Despite significant advances in the knowledge of its pathophysiology, all innovative therapeutic approaches and interventions have failed to improve outcome. In the previous...

AT1 receptor-associated protein and septic shock-induced vascular hyporeactivity: another 'magic bullet' in the pipe?

Septic shock remains an important issue for critical care physicians. Despite significant advances in the knowledge of its pathophysiology, new effective therapeutic approaches have yet to emerge. Consequently, research on its pathophysiology must be continued. In a recent study, Katharina Mederle and colleagues explored the impact of angiotensin 1 receptor-associated protein 1...

Prolonged prone positioning under VV-ECMO is safe and improves oxygenation and respiratory compliance

Background Data are sparse regarding the effects of prolonged prone positioning (PP) during VV-ECMO. Previous studies, using short sessions (<12 h), failed to find any effects on respiratory system compliance. In the present analysis, the effects of prolonged PP sessions (24 h) were retrospectively studied with regard to safety data, oxygenation and respiratory system compliance...

New conclusive data on human myocardial dysfunction induced by acidosis

Acidosis is one of the major consequences of hemodynamic instability in shock state patients directly associated with multiple organ failure evolution and death. Most studies on the hemodynamic consequences of acidosis have been experimental, nonhuman studies with severe acidosis, and thus far from the most common clinical situations. Schotola and colleagues offer a new approach...

Changes in cardiac arrest patients’ temperature management after the 2013 “TTM” trial: results from an international survey

Background Therapeutic hypothermia (TH between 32 and 34 °C) was recommended until recently in unconscious successfully resuscitated cardiac arrest (CA) patients, especially after initial shockable rhythm. A randomized controlled trial published in 2013 observed similar outcome between a 36 °C-targeted temperature management (TTM) and a 33 °C-TTM. The main aim of our study was to...

Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury

Introduction Haemorrhagic shock is associated with an inflammatory response consecutive to ischaemia-reperfusion (I/R) that leads to cardiovascular failure and organ injury. The role of and the timing of administration of hydrogen sulphide (H2S) remain uncertain. Vascular effects of H2S are mainly mediated through K+ATP-channel activation. Herein, we compared the effects of D,L...

Outcomes of patients admitted to intensive care units for acute manifestation of small-vessel vasculitis: a multicenter, retrospective study

Background The outcomes of patients admitted to the intensive care unit (ICU) for acute manifestation of small-vessel vasculitis are poorly reported. The aim of the present study was to determine the mortality rate and prognostic factors of patients admitted to the ICU for acute small-vessel vasculitis. Methods This retrospective, multicenter study was conducted from January 2001...

French Intensive Care Society, International congress – Réanimation 2016

Laithier, Antoine Kimmoun, Tahar Chouihed, Stéphane Albizzati, Edoardo Camenzind, Fabrice Vanhuyse, Bruno Levy O27 Decreased monocyte HLA-DR expression after out-of-hospital cardiac arrest Martin Cour ... cardiaque, Centre Hospitalier Universitaire de Nancy, Vandoeuvre‑lès‑Nancy, France Correspondence: Antoine Kimmoun ‑ Annals of Intensive Care 2016, 6(Suppl 1):O26 Introduction There is a growing interest