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Homozygosity for the Ala Allele of the PPARγ2 Pro12Ala Polymorphism Is Associated with Reduced Risk of Coronary Artery Disease

Several studies suggest that the peroxisome proliferator-activated receptor gamma (PPARγ) is involved in atherogenesis. The Pro12Ala polymorphism in the gene encoding PPARγ (PPARγ2 gene) influences the risk for type 2 diabetes. Two population-based studies have shown that the Ala allele is associated with reduced carotid intimal-medial thickness (IMT). However, studies focusing...

Homozygosity for the Ala Allele of the PPARγ2 Pro12Ala Polymorphism Is Associated with Reduced Risk of Coronary Artery Disease

Several studies suggest that the peroxisome proliferator-activated receptor gamma (PPARγ) is involved in atherogenesis. The Pro12Ala polymorphism in the gene encoding PPARγ (PPARγ2 gene) influences the risk for type 2 diabetes. Two population-based studies have shown that the Ala allele is associated with reduced carotid intimal-medial thickness (IMT). However, studies focusing...

C-Peptide Response and HLA Genotypes in Subjects With Recent-Onset Type 1 Diabetes After Immunotherapy With DiaPep277: An Exploratory Study

OBJECTIVE To investigate whether lower risk HLA class II genotypes would influence the efficacy of DiaPep277 therapy in protecting β-cell function evaluated by C-peptide secretion in recent-onset type 1 diabetic subjects.

Zinc Transporter 8 Antibodies Complement GAD and IA-2 Antibodies in the Identification and Characterization of Adult-Onset Autoimmune Diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4

VITO LAMPASONA BSC ANTONIO PETRONE PHD CLAUDIO TIBERTI MARCO CAPIZZI MARIALUISA SPOLETINI SERGIO DI PIETRO MARCO SONGINI SARA BONICCHIO BSC OBJECTIVE - Zinc transporter 8 (ZnT8) is an islet -cell

The PTPN22 1858T Gene Variant in Type 1 Diabetes Is Associated With Reduced Residual β-Cell Function and Worse Metabolic Control

ANTONIO PETRONE PHD MARIALUISA SPOLETINI PHD SIMONA ZAMPETTI MARCO CAPIZZI SARA ZAVARELLA PHD JOHN OSBORN PHD PAOLO POZZILLI RAFFAELLA BUZZETTI FOR THE IMMUNOTHERAPY DIABETES (IMDIAB) GROUP

The Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Is Associated With High GAD Antibody Titer in Latent Autoimmune Diabetes in Adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3

ANTONIO PETRONE PHD CONCETTA SURACI MARCO CAPIZZI ANDREA GIACCARI PHD EMANUELE BOSI CLAUDIO TIBERTI ATA OBJECTIVE - We previously demonstrated the presence of two different populations among

PPAR-γ2 Pro12Ala Variant Is Associated with Greater Insulin Sensitivity in Childhood Obesity

Several genetic variants of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2), a molecule known to be involved in transcription of target genes, have been identified. Pro12Ala, a missense mutation in exon 2 of the gene, is highly prevalent in Caucasian populations. Conflicting conclusions about the association between this mutation and complex traits such as obesity...

High Titer of Autoantibodies to GAD Identifies a Specific Phenotype of Adult-Onset Autoimmune Diabetes

; Palermo Universit a`: Aldo Galluzzo and Carla Giordano; Cagliari Universit a`: Efisio Cossu; Sassari Universit a`: Mario Maioli. Genetics: Rome, La Sapienza Universita` : Raffaella Buzzetti and Antonio ... Petrone.

IL12B Polymorphism and Type 1 Diabetes in the Italian Population: A Case-Control Study

A polymorphism in the interleukin 12B gene was recently reported to be strongly associated with type 1 diabetes in 422 Australian and British families. We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease.

The Gly972→Arg IRS-1 Variant Is Associated With Type 1 Diabetes in Continental Italy

The Arg972 insulin receptor substrate-1 (IRS-1) variant has been hypothesized to play a role in pancreatic β-cell stimulus-coupled insulin secretion and survival. We analyzed the relations between type 1 diabetes and the Arg972 IRS-1 variant. The frequency of the IRS-1 Arg972 variant was investigated in two independent sets of unrelated patients: a case-control study and a...