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35 papers found.
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IL28B rs12979860 genotype as a predictor marker of progression to BKVirus Associated nephropathy, after kidney transplantation

BK virus (BKV) associated nephropathy (BKVAN) is still an important cause of allograft dysfunction after kidney transplantation (KT). Recent data have shown that the new interferon (IFN)-λ family has been ascribed antiviral properties similar to IFNα, and that the response to IFNλ in kidney is restricted to epithelial cells, suggesting that the IFNλ system evolves as specific...

Metabolomic Profiling in Individuals with a Failing Kidney Allograft

Background Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. Methods To explore metabolomic abnormalities in individuals with a failing kidney allograft, we analyzed by liquid chromatography-mass spectrometry (LC-MS/MS; for ex vivo profiling of serum and urine) and two dimensional correlated spectroscopy (2D COSY; for in vivo...

Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes

Bone-marrow-derived cells-mediated postnatal vasculogenesis has been reported as the main responsible for the regulation of vascular homeostasis in adults. Since their discovery, endothelial progenitor cells have been depicted as mediators of postnatal vasculogenesis for their peculiar phenotype (partially staminal and partially endothelial), their ability to differentiate in...

Endothelial Progenitor Cells Carrying Monocyte Markers Are Selectively Abnormal in Type 1 Diabetic Patients With Early Retinopathy

Gianpaolo Zerbini Anna Maestroni Alessio Palini Gemma Tremolada Rosangela Lattanzio Silvia Maestroni Matteo Rocco Pastore Antonio Secchi Riccardo Bonfanti Chiara Gerhardinger Mara Lorenzi

Autologous Pancreatic Islet Transplantation in Human Bone Marrow. Diabetes 2013;62:3523–3531

, Massimo Bernardi, Alessandro Del Maschio, Carlo Staudacher, Claudio Doglioni, Fabio Ciceri, Antonio Secchi, and Lorenzo Piemonti In the article listed above, there is an error in Fig. 3. In panel B, the

Islet Transplantation Stabilizes Hemostatic Abnormalities and Cerebral Metabolism in Individuals With Type 1 Diabetes

OBJECTIVE Islets after kidney transplantation have been shown to positively affect the quality of life of individuals with type 1 diabetes (T1D) by reducing the burden of diabetes complications, but fewer data are available for islet transplantation alone (ITA). The aim of this study was to assess whether ITA has a positive impact on hemostatic and cerebral abnormalities in...

Autologous Pancreatic Islet Transplantation in Human Bone Marrow

Jacopo Peccatori Elisa Cantarelli Carlo Messina Massimo Bernardi Alessandro Del Maschio Carlo Staudacher Claudio Doglioni Fabio Ciceri Antonio Secchi Lorenzo Piemonti The liver is the current site of

Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes

Espadas de Arias Mario Scalamogna Emanuele Bosi Ezio Bonifacio Antonio Secchi Paul I. Terasaki Long-term clinical outcome of islet transplantation is hampered by the rejection and recurrence of

Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

Alessandra Ferraro Carlo Socci Angela Stabilini Andrea Valle Paolo Monti Lorenzo Piemonti Rita Nano Sven Olek Paola Maffi Marina Scavini Antonio Secchi Carlo Staudacher Ezio Bonifacio Manuela

Near Normalization of Metabolic and Functional Features of the Central Nervous System in Type 1 Diabetic Patients With End-Stage Renal Disease After Kidney-Pancreas Transplantation

VEZZULLI ROBERTO BASSI CHIARA GREMIZZI MONICA FALAUTANO FRANCESCA D'ADDIO ANDREA VERGANI LOLA CHABTINI ERICA ALTAMURA ALESSANDRA MELLO ROSSANA CALDARA MARINA SCAVINI GIUSEPPE MAGNANI ANDREA FALINI ANTONIO ... SECCHI OBJECTIVEdThe pathogenesis of brain disorders in type 1 diabetes (T1D) is multifactorial and involves the adverse effects of chronic hyperglycemia and of recurrent hypoglycemia. Kidneypancreas (KP

Inotuzumab Ozogamicin Murine Analog–Mediated B-Cell Depletion Reduces Anti-islet Allo- and Autoimmune Responses

Michele Carvello Alessandra Petrelli Andrea Vergani Kang Mi Lee Sara Tezza Melissa Chin Elena Orsenigo Carlo Staudacher Antonio Secchi Kyri Dunussi-Joannopoulos Mohamed H. Sayegh James F. Markmann

Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection

Andrea Vergani Carmen Fotino Francesca D'Addio Sara Tezza Michele Podetta Francesca Gatti Melissa Chin Roberto Bassi Ruth D. Molano Domenico Corradi Rita Gatti Maria E. Ferrero Antonio Secchi Fabio

Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4+CD25+FOXP3+ Regulatory T-Cells

Paolo Monti Miriam Scirpoli Paola Maffi Lorenzo Piemonti Antonio Secchi Ezio Bonifacio Maria-Grazia Roncarolo Manuela Battaglia OBJECTIVE-Rapamycin is an immunosuppressive drug currently used to

Transplant Estimated Function: A simple index to evaluate β-cell secretion after islet transplantation

OBJECTIVE—The β-score is a highly regarded approach to the assessment of transplant functionality. Our aim was to develop an index of β-cell function that hinges on the pillars of the β-score (daily insulin requirement and A1C), has a straightforward physiological interpretation, and does not require the execution of an insulin stimulation test. RESEARCH DESIGN AND METHODS—The...

Metabolic results 3 years after simultaneous pancreas–kidney transplantation

Background. Simultaneous pancreas–kidney (SPK) transplantation has become accepted therapy for patients with type 1 diabetes and end-stage renal disease. This 3-year study compared the metabolic effects of tacrolimus- and cyclosporin microemulsion (ME)-based immunosuppressive therapy in this clinical setting. Methods. The study population comprised the 205 patients enrolled in...

Metabolic and Immunological Features of the Failing Islet-Transplanted Patient

OBJECTIVE—This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure. RESEARCH DESIGN AND METHODS—We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term...

IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response

Alessandra Petrelli Michele Carvello Andrea Vergani Kang Mi Lee Sara Tezza Ming Du Sonja Kleffel Liu Chengwen Bechara G. Mfarrej Patrick Hwu Antonio Secchi Warren J. Leonard Deborah Young Mohamed H