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Search: authors:"Archana Swami"

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Protein corona: implications for nanoparticle interactions with pulmonary cells

We previously showed that cerium oxide (CeO2), barium sulfate (BaSO4) and zinc oxide (ZnO) nanoparticles (NPs) exhibited different lung toxicity and pulmonary clearance in rats. We hypothesize that these NPs acquire coronas with different protein compositions that may influence their clearance from the lungs. CeO2, silica-coated CeO2, BaSO4, and ZnO NPs were incubated in rat lung...

Silica coating influences the corona and biokinetics of cerium oxide nanoparticles

Background The physicochemical properties of nanoparticles (NPs) influence their biological outcomes. Methods We assessed the effects of an amorphous silica coating on the pharmacokinetics and pulmonary effects of CeO 2 NPs following intratracheal (IT) instillation, gavage and intravenous injection in rats. Uncoated and silica-coated CeO 2 NPs were generated by flame spray...