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Translocated duplication of a targeted chromosomal segment enhances gene expression at the duplicated site and results in phenotypic changes in Aspergillus oryzae

BackgroundTranslocated chromosomal duplications occur spontaneously in many organisms; segmental duplications of large chromosomal regions are expected to result in phenotypic changes because of gene dosage effects. Therefore, experimentally generated segmental duplications in targeted chromosomal regions can be used to study phenotypic changes and determine the functions of...

External release of entropy by synchronized movements of local secondary structures drives folding of a small, disulfide-bonded protein

opportunity to determine the crystal structure of erabutoxin b from an electron density map. Data curation: Atsushi Sato. Formal analysis: Atsushi Sato. Investigation: Atsushi Sato. Methodology: Atsushi ... Sato. Project administration: Andre Menez. Supervision: Andre Menez. Validation: Atsushi Sato. Visualization: Atsushi Sato. Writing ? original draft: Atsushi Sato. Writing ? review & editing

Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway

, Culture, Sports , Science and Technology of Japan , 26460386, to Dr. Atsushi Sato; and Nanken-Kyoten, TMDU, 17M03, to Prof. Hiroshi Shibuya 2 Editor: Renping Zhou, Rutgers University , UNITED STATES The ... : Hiroshi Shibuya. Data curation: Atsushi Sato, Hiroshi Shibuya. Formal analysis: Atsushi Sato. Supervision: Hiroshi Shibuya. Validation: Atsushi Sato. Visualization: Atsushi Sato. Writing ± original

Design of fusion technique-based mining engine for smart business

Keys to successful implementation of smart business require a wide spectrum of domain knowledge, experts, and their correlated experiences. Excluding those external factors—which can be collected by well-deployed sensors—being aware of user (or consumer) has the highest priority on the to-do-list. The more user is understood, the more user can be satisfied from an intuitive point...

Peritoneal metastasis as a predictive factor for nab-paclitaxel in patients with pretreated advanced gastric cancer: an exploratory analysis of the phase III ABSOLUTE trial

BackgroundIn the ABSOLUTE trial, weekly nanoparticle albumin-bound paclitaxel (w-nab-PTX) showed non-inferiority to weekly solvent-based paclitaxel (w-sb-PTX) for overall survival (OS). Thus, w-nab-PTX might be an option for second-line chemotherapy in advanced gastric cancer (AGC). However, predictive factors for efficacies of these agents have not been evaluated.MethodsPatients...

Hierarchy of Dysfunction Related to Dressing Performance in Stroke Patients: A Path Analysis Study

Previous reports indicated that various dysfunctions caused by stroke affect the level of independence in dressing. These dysfunctions can be hierarchical, and these effects on dressing performance can be complicated in stroke patients. However, there are no published reports focusing on the hierarchical structure of the relationships between the activities of daily living and...

WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression

WNK kinase family is conserved among many species and regulates SPAK/OSR1 and ion co-transporters. Some mutations in human WNK1 or WNK4 are associated with Pseudohypoaldosteronism type II, a form of hypertension. WNK is also involved in developmental and cellular processes, but the molecular mechanisms underlying its regulation in these processes remain unknown. Here, we identify...

Air-Drying of Cells, the Novel Conditions for Stimulated Synthesis of Triacylglycerol in a Green Alga, Chlorella kessleri

Triacylglycerol is used for the production of commodities including food oils and biodiesel fuel. Microalgae can accumulate triacylglycerol under adverse environmental conditions such as nitrogen-starvation. This study explored the possibility of air-drying of green algal cells as a novel and simple protocol for enhancement of their triacylglycerol content. Chlorella kessleri...

Study protocol of the TRICOLORE trial: a randomized phase III study of oxaliplatin-based chemotherapy versus combination chemotherapy with S-1, irinotecan, and bevacizumab as first-line therapy for metastatic colorectal cancer

Background Metastatic colorectal cancer carries a poor prognosis and cannot be cured by currently available therapy. Chemotherapy designed to prolong survival and improve the quality of life (QOL) of patients is the mainstay of treatment. Standard regimens of FOLFOX/bevacizumab and CapeOX/bevacizumab can cause neurotoxicity, potentially disrupting treatment. The results of 3...

Involvement of the TNF and FasL Produced by CD11b Kupffer Cells/Macrophages in CCl4-Induced Acute Hepatic Injury

We previously reported that F4/80+ Kupffer cells are subclassified into CD68+ Kupffer cells with phagocytic and ROS producing capacity, and CD11b+ Kupffer cells with cytokine-producing capacity. Carbon tetrachloride (CCl4)-induced hepatic injury is a well-known chemical-induced hepatocyte injury. In the present study, we investigated the immunological role of Kupffer cells...

Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)

Background Adult human mesenchymal stem/stromal cells (hMSCs) from bone marrow have been reported to exhibit beneficial effects on spinal cord injury (SCI). A neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP) is known to decrease neuronal cell death and inflammatory response after ischemia, SCI, and other neuronal disorders. Recently, we found that...

The Effect of Synthetic C-Reactive Protein on the In Vitro Immune Response of Human PBMCs Stimulated with Bacterial Reagents

Synthetic C-reactive protein (CRP) rescues mice from lethal endotoxin shock or bacterial infection by suppressing tumor necrosis factor (TNF-α), but in turn, enhances Kupffer cell phagocytic activity. We herein assessed the influence of CRP in human peripheral blood mononuclear cells (PBMCs). When human PBMCs were stimulated in vitro with penicillin-treated Streptococcus pyogenes...

Activation of CD11b+ Kupffer Cells/Macrophages as a Common Cause for Exacerbation of TNF/Fas-Ligand-Dependent Hepatitis in Hypercholesterolemic Mice

We have reported that the mouse hepatic injury induced by either α-galactosylceramide (α-GalCer) or bacterial DNA motifs (CpG-ODN) is mediated by the TNF/NKT cell/Fas-ligand (FasL) pathway. In addition, F4/80+ Kupffer cells can be subclassified into CD68+ subset with a phagocytosing capacity and CD11b+ subset with a TNF-producing capacity. CD11b+ subset increase if mice are fed...

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling

Dishevelled (DVL) is a central factor in the Wnt signaling pathway, which is highly conserved among various organisms. DVL plays important roles in transcriptional activation in the nucleus, but the molecular mechanisms underlying their nuclear localization remain unclear. In the present study, we identified IQGAP1 as a regulator of DVL function. In Xenopus embryos, depletion of...

Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury

Background Microglia and macrophages (MG/MΦ) have a diverse range of functions depending on unique cytokine stimuli, and contribute to neural cell death, repair, and remodeling during central nervous system diseases. While IL-1 has been shown to exacerbate inflammation, it has also been recognized to enhance neuroregeneration. We determined the activating phenotype of MG/MΦ and...

Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia

Hara, Megumi Oda, Atsushi Sato and Keizo Horibe. The lead author for JACLS in this manuscript is Toshihiko Imamura (). Conceived and designed the experiments: HY TI. Analyzed the data: HY TI A. Saito

Changing Arctic snow cover: A review of recent developments and assessment of future needs for observations, modelling, and impacts

, University of Bergen, 5020 Bergen, Norway. e-mail: Atsushi Sato is a senior expert researcher at the Snow and ice Research Center of the National Research Institute for Earch Science and Disaster Prevention

Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells

Glioblastoma, the most intractable cerebral tumor, is highly lethal. Recent studies suggest that cancer stem-like cells (CSLCs) have the capacity to repopulate tumors and mediate radio- and chemoresistance, implying that future therapies may need to turn from the elimination of rapidly dividing, but differentiated, tumor cells to specifically targeting the minority of tumor cells...

A phase II study of doxifluridine and docetaxel combination chemotherapy for advanced or recurrent gastric cancer

Background The aim of this study was to establish the efficacy and safety of doxifluridine and docetaxel for patients with advanced or recurrent gastric cancer. Methods The regimen consisted of oral administration of doxifluridine 533 mg/m2 per day on days 1–14 and an intravenous infusion of docetaxel 50 mg/m2 on day 8. The primary endpoint was the overall response rate. The...