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36 papers found.
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Translocated duplication of a targeted chromosomal segment enhances gene expression at the duplicated site and results in phenotypic changes in Aspergillus oryzae

BackgroundTranslocated chromosomal duplications occur spontaneously in many organisms; segmental duplications of large chromosomal regions are expected to result in phenotypic changes because of gene dosage effects. Therefore, experimentally generated segmental duplications in targeted chromosomal regions can be used to study phenotypic changes and determine the functions of...

External release of entropy by synchronized movements of local secondary structures drives folding of a small, disulfide-bonded protein

opportunity to determine the crystal structure of erabutoxin b from an electron density map. Data curation: Atsushi Sato. Formal analysis: Atsushi Sato. Investigation: Atsushi Sato. Methodology: Atsushi ... Sato. Project administration: Andre Menez. Supervision: Andre Menez. Validation: Atsushi Sato. Visualization: Atsushi Sato. Writing ? original draft: Atsushi Sato. Writing ? review & editing

Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic autism spectrum disorder (ASD), such as tuberous sclerosis complex (TSC). Treatment with the mTOR inhibitor rapamycin improved social interaction deficits in mouse models of...

Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway

, Culture, Sports , Science and Technology of Japan , 26460386, to Dr. Atsushi Sato; and Nanken-Kyoten, TMDU, 17M03, to Prof. Hiroshi Shibuya 2 Editor: Renping Zhou, Rutgers University , UNITED STATES The ... : Hiroshi Shibuya. Data curation: Atsushi Sato, Hiroshi Shibuya. Formal analysis: Atsushi Sato. Supervision: Hiroshi Shibuya. Validation: Atsushi Sato. Visualization: Atsushi Sato. Writing ± original

Design of fusion technique-based mining engine for smart business

Keys to successful implementation of smart business require a wide spectrum of domain knowledge, experts, and their correlated experiences. Excluding those external factors—which can be collected by well-deployed sensors—being aware of user (or consumer) has the highest priority on the to-do-list. The more user is understood, the more user can be satisfied from an intuitive point...

Peritoneal metastasis as a predictive factor for nab-paclitaxel in patients with pretreated advanced gastric cancer: an exploratory analysis of the phase III ABSOLUTE trial

BackgroundIn the ABSOLUTE trial, weekly nanoparticle albumin-bound paclitaxel (w-nab-PTX) showed non-inferiority to weekly solvent-based paclitaxel (w-sb-PTX) for overall survival (OS). Thus, w-nab-PTX might be an option for second-line chemotherapy in advanced gastric cancer (AGC). However, predictive factors for efficacies of these agents have not been evaluated.MethodsPatients...

Severe Dextran-Induced Anaphylactic Shock during Induction of Hypertension-Hypervolemia-Hemodilution Therapy following Subarachnoid Hemorrhage

Dextran is a colloid effective for volume expansion; however, a possible side effect of its use is anaphylaxis. Dextran-induced anaphylactoid reaction (DIAR) is a rare but severe complication, with a small dose of dextran solution sufficient to induce anaphylaxis. An 86-year-old female who underwent clipping for a ruptured cerebral aneurysm was admitted to the intensive care unit...

Hierarchy of Dysfunction Related to Dressing Performance in Stroke Patients: A Path Analysis Study

Previous reports indicated that various dysfunctions caused by stroke affect the level of independence in dressing. These dysfunctions can be hierarchical, and these effects on dressing performance can be complicated in stroke patients. However, there are no published reports focusing on the hierarchical structure of the relationships between the activities of daily living and...

WNK Signaling Is Involved in Neural Development via Lhx8/Awh Expression

WNK kinase family is conserved among many species and regulates SPAK/OSR1 and ion co-transporters. Some mutations in human WNK1 or WNK4 are associated with Pseudohypoaldosteronism type II, a form of hypertension. WNK is also involved in developmental and cellular processes, but the molecular mechanisms underlying its regulation in these processes remain unknown. Here, we identify...

Air-Drying of Cells, the Novel Conditions for Stimulated Synthesis of Triacylglycerol in a Green Alga, Chlorella kessleri

Triacylglycerol is used for the production of commodities including food oils and biodiesel fuel. Microalgae can accumulate triacylglycerol under adverse environmental conditions such as nitrogen-starvation. This study explored the possibility of air-drying of green algal cells as a novel and simple protocol for enhancement of their triacylglycerol content. Chlorella kessleri...

Randomized Phase II Study of Docetaxel plus Personalized Peptide Vaccination versus Docetaxel plus Placebo for Patients with Previously Treated Advanced Wild Type EGFR Non-Small-Cell Lung Cancer

Koichi Takayama,1 Shunichi Sugawara,2 Yasuo Saijo,3 Makoto Maemondo,4 Atsushi Sato,5 Shinzo Takamori,6 Taishi Harada,7 Tetsuro Sasada,8 Tatsuyuki Kakuma,9 Junji Kishimoto,10 Akira Yamada,11 Masanori

Study protocol of the TRICOLORE trial: a randomized phase III study of oxaliplatin-based chemotherapy versus combination chemotherapy with S-1, irinotecan, and bevacizumab as first-line therapy for metastatic colorectal cancer

Background Metastatic colorectal cancer carries a poor prognosis and cannot be cured by currently available therapy. Chemotherapy designed to prolong survival and improve the quality of life (QOL) of patients is the mainstay of treatment. Standard regimens of FOLFOX/bevacizumab and CapeOX/bevacizumab can cause neurotoxicity, potentially disrupting treatment. The results of 3...

Involvement of the TNF and FasL Produced by CD11b Kupffer Cells/Macrophages in CCl4-Induced Acute Hepatic Injury

We previously reported that F4/80+ Kupffer cells are subclassified into CD68+ Kupffer cells with phagocytic and ROS producing capacity, and CD11b+ Kupffer cells with cytokine-producing capacity. Carbon tetrachloride (CCl4)-induced hepatic injury is a well-known chemical-induced hepatocyte injury. In the present study, we investigated the immunological role of Kupffer cells...

Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)

Background Adult human mesenchymal stem/stromal cells (hMSCs) from bone marrow have been reported to exhibit beneficial effects on spinal cord injury (SCI). A neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP) is known to decrease neuronal cell death and inflammatory response after ischemia, SCI, and other neuronal disorders. Recently, we found that...

The Effect of Synthetic C-Reactive Protein on the In Vitro Immune Response of Human PBMCs Stimulated with Bacterial Reagents

Synthetic C-reactive protein (CRP) rescues mice from lethal endotoxin shock or bacterial infection by suppressing tumor necrosis factor (TNF-α), but in turn, enhances Kupffer cell phagocytic activity. We herein assessed the influence of CRP in human peripheral blood mononuclear cells (PBMCs). When human PBMCs were stimulated in vitro with penicillin-treated Streptococcus pyogenes...

Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

University, Tokyo 113 8421, JapanToshiyuki Kobayashi & Okio Hino AuthorsSearch for Atsushi Sato in:Nature Research journals • PubMed • Google ScholarSearch for Shinya Kasai in:Nature Research journals • PubMed

Activation of CD11b+ Kupffer Cells/Macrophages as a Common Cause for Exacerbation of TNF/Fas-Ligand-Dependent Hepatitis in Hypercholesterolemic Mice

We have reported that the mouse hepatic injury induced by either α-galactosylceramide (α-GalCer) or bacterial DNA motifs (CpG-ODN) is mediated by the TNF/NKT cell/Fas-ligand (FasL) pathway. In addition, F4/80+ Kupffer cells can be subclassified into CD68+ subset with a phagocytosing capacity and CD11b+ subset with a TNF-producing capacity. CD11b+ subset increase if mice are fed...

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling

Dishevelled (DVL) is a central factor in the Wnt signaling pathway, which is highly conserved among various organisms. DVL plays important roles in transcriptional activation in the nucleus, but the molecular mechanisms underlying their nuclear localization remain unclear. In the present study, we identified IQGAP1 as a regulator of DVL function. In Xenopus embryos, depletion of...

Dorsal-ventral midline signaling in the developing Drosophila eye

Atsushi Sato Andrew Tomlinson Boundaries between different cell types play key roles in many developmental patterning processes. They can be established by various mechanisms, and signaling between