Advanced search    

Search: authors:"Atsushi Sato"

38 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer

Cell cycle progression is monitored by checkpoint mechanisms to ensure the integrity of the genome and the fidelity of sister chromatid separation. Failure of such checkpoint functions results in genomic instability, a condition that predisposes cells to neoplastic transformation and tumor progression. Recently, Scolnick and Halazonetis defined a new mitotic checkpoint that acts...

The association between masked hypertension and waist circumference as an obesity-related anthropometric index for metabolic syndrome: the Ohasama study

Masked hypertension has been proven to be associated with an increased risk for cardiovascular diseases. The purpose of this study was to examine the direct associations of obesity-related anthropometric indices, including waist circumference, with masked hypertension. Participants in this population-based survey included 395 residents (35 years) of Ohasama, a rural Japanese...

Effectiveness of doxifluridine (5′-DFUR)/docetaxel against advanced/recurrent gastric cancer showing resistance to various anticancer drug regimens

Atsushi Sato Ken Shimada Masatoshi Nakamachi Jun Ushio Wataru Yamamoto Minoru Kurihara Masaaki Matsukawa A 58-year-old man was diagnosed as having type 3 gastric cancer (poorly differentiated

Early Interleukin 4–Dependent Response Can Induce Airway Hyperreactivity before Development of Airway Inflammation in a Mouse Model of Asthma

). Author information AffiliationsDepartment of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, JapanYasuo To, Makoto Dohi, Ryoichi Tanaka, Atsushi Sato, Kazuyuki Nakagome ... in:Nature Research journals • PubMed • Google ScholarSearch for Atsushi Sato in:Nature Research journals • PubMed • Google ScholarSearch for Kazuyuki Nakagome in:Nature Research journals • PubMed • Google

Antigen-sensitized CD4+CD62Llow memory/effector T helper 2 cells can induce airway hyperresponsiveness in an antigen free setting

Background Airway hyperresponsiveness (AHR) is one of the most prominent features of asthma, however, precise mechanisms for its induction have not been fully elucidated. We previously reported that systemic antigen sensitization alone directly induces AHR before development of eosinophilic airway inflammation in a mouse model of allergic airway inflammation, which suggests a...

Proposal of a Risk-Stratification System for the Japanese Population Based on Blood Pressure Levels: The Ohasama Study

The aim of the present study was to propose a risk-stratification system based on self-measurement of home blood pressure (HBP) as well as casual-screening BP (CBP) in relation to Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2004). For 4 weeks, the subjects measured their HBP while seated every morning within 1 h after awaking, after having...

Efficacy and safety of capecitabine plus cisplatin in Japanese patients with advanced or metastatic gastric cancer: subset analyses of the AVAGAST study and the ToGA study

BackgroundCapecitabine plus cisplatin (XP) is recognized as one of the global standard first-line chemotherapy regimens for patients with metastatic gastric cancer (mGC). Recent multinational phase III trials in mGC have been conducted with XP as the control arm, although no data on XP in Japanese patients with mGC have been published to date. The AVAGAST (XP ± bevacizumab in mGC...

Potent Antimalarial and Transmission-Blocking Activities of Centanamycin, a Novel DNA-Binding Agent

Most treatments for malaria target the blood stage of infection in the human host, although few can also block transmission of the parasite to the mosquito. We show here that the compound centanamycin is very effective against blood-stage malarial infections in vitro and in vivo and has profound effects on sexual differentiation of the parasites in mosquitoes. After drug...

A phase II study of doxifluridine and docetaxel combination chemotherapy for advanced or recurrent gastric cancer

Background The aim of this study was to establish the efficacy and safety of doxifluridine and docetaxel for patients with advanced or recurrent gastric cancer. Methods The regimen consisted of oral administration of doxifluridine 533 mg/m2 per day on days 1–14 and an intravenous infusion of docetaxel 50 mg/m2 on day 8. The primary endpoint was the overall response rate. The...

Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells

Glioblastoma, the most intractable cerebral tumor, is highly lethal. Recent studies suggest that cancer stem-like cells (CSLCs) have the capacity to repopulate tumors and mediate radio- and chemoresistance, implying that future therapies may need to turn from the elimination of rapidly dividing, but differentiated, tumor cells to specifically targeting the minority of tumor cells...

Changing Arctic snow cover: A review of recent developments and assessment of future needs for observations, modelling, and impacts

, University of Bergen, 5020 Bergen, Norway. e-mail: Atsushi Sato is a senior expert researcher at the Snow and ice Research Center of the National Research Institute for Earch Science and Disaster Prevention

Targeting JNK for therapeutic depletion of stem-like glioblastoma cells

Matsuda & Atsushi Sato These authors contributed equally to this work. AffiliationsDepartment of Molecular Cancer Science, Yamagata University School of Medicine, Yamagata, 990-9585, JapanKen-ichiro ... Matsuda, Atsushi Sato, Masashi Okada, Keita Shibuya, Shizuka Seino, Kaori Suzuki, Eriko Watanabe & Chifumi KitanakaDepartment of Neurosurgery, Yamagata University School of Medicine, Yamagata, 990-9585

Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia

Hara, Megumi Oda, Atsushi Sato and Keizo Horibe. The lead author for JACLS in this manuscript is Toshihiko Imamura (). Conceived and designed the experiments: HY TI. Analyzed the data: HY TI A. Saito

Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury

Background Microglia and macrophages (MG/MΦ) have a diverse range of functions depending on unique cytokine stimuli, and contribute to neural cell death, repair, and remodeling during central nervous system diseases. While IL-1 has been shown to exacerbate inflammation, it has also been recognized to enhance neuroregeneration. We determined the activating phenotype of MG/MΦ and...

Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury

Microglia and macrophages (MG/MΦ) have a diverse range of functions depending on unique cytokine stimuli, and contribute to neural cell death, repair, and remodeling during central nervous system diseases. While IL-1 has been shown to exacerbate inflammation, it has also been recognized to enhance neuroregeneration. We determined the activating phenotype of MG/MΦ and the impact...

Dorsal-ventral midline signaling in the developing Drosophila eye

Atsushi Sato Andrew Tomlinson Boundaries between different cell types play key roles in many developmental patterning processes. They can be established by various mechanisms, and signaling between

IQGAP1 Functions as a Modulator of Dishevelled Nuclear Localization in Wnt Signaling

Dishevelled (DVL) is a central factor in the Wnt signaling pathway, which is highly conserved among various organisms. DVL plays important roles in transcriptional activation in the nucleus, but the molecular mechanisms underlying their nuclear localization remain unclear. In the present study, we identified IQGAP1 as a regulator of DVL function. In Xenopus embryos, depletion of...

Activation of CD11b+ Kupffer Cells/Macrophages as a Common Cause for Exacerbation of TNF/Fas-Ligand-Dependent Hepatitis in Hypercholesterolemic Mice

We have reported that the mouse hepatic injury induced by either α-galactosylceramide (α-GalCer) or bacterial DNA motifs (CpG-ODN) is mediated by the TNF/NKT cell/Fas-ligand (FasL) pathway. In addition, F4/80+ Kupffer cells can be subclassified into CD68+ subset with a phagocytosing capacity and CD11b+ subset with a TNF-producing capacity. CD11b+ subset increase if mice are fed...