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Mutual Antagonism between Circadian Protein Period 2 and Hepatitis C Virus Replication in Hepatocytes

Background Hepatitis C virus (HCV) infects approximately 3% of the world population and is the leading cause of liver disease, impacting hepatocyte metabolism, depending on virus genotype. Hepatic metabolic functions show rhythmic fluctuations with 24-h periodicity (circadian), driven by molecular clockworks ticking through translational-transcriptional feedback loops, operated...

Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma

Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Prevention and risk reduction are important and the identification of specific biomarkers for early diagnosis of HCC represents an active field of research. Increasing evidence indicates that fat accumulation in the liver, defined as hepatosteatosis, is an independent and strong risk factor for...

Abstracts from the 2011 BNOS Conference, June 29 – July 1, 2011, Homerton College, Cambridge

IN DNA DAMAGE IN NEURAL STEM CELLS AND IN GLIOBLASTOMA INITIATING CELLS Azzura Greco, Serena Acquati, and Silvia Marino; Barts and the London School of Medicine and Dentistry, Blizard Institute