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The application of NIPT using combinatorial probe-anchor synthesis to identify sex chromosomal aneuploidies (SCAs) in a cohort of 570 pregnancies

Non-invasive prenatal testing (NIPT) as alternative screening method had been proven to have very high sensitivity and specificity for detecting common aneuploidies such as T21, T18, and T13, with low false positive and false negative rates. Unfortunately, recent studies suggested that the NIPT achieved lower accuracy in sex chromosomal aneuploidies (SCAs) detection than...

Search for single production of the vector-like top partner at the 14 TeV LHC

. Y. Kats , M. McCullough , G. Perez , Y. Soreq , J. Thaler, JHEP 1706 , 126 ( 2017 ) 72. G. Couture, M. Frank , C. Hamzaoui , M. Toharia , Phys. Rev. D 95 , 095038 ( 2017 ) 73. Yao-Bei Liu , Nucl. Phys

Effects of Scan Resolutions and Element Sizes on Bovine Vertebral Mechanical Parameters from Quantitative Computed Tomography-Based Finite Element Analysis

Quantitative computed tomography-based finite element analysis (QCT/FEA) has been developed to predict vertebral strength. However, QCT/FEA models may be different with scan resolutions and element sizes. The aim of this study was to explore the effects of scan resolutions and element sizes on QCT/FEA outcomes. Nine bovine vertebral bodies were scanned using the clinical CT...

Effects of Scan Resolutions and Element Sizes on Bovine Vertebral Mechanical Parameters from Quantitative Computed Tomography-Based Finite Element Analysis

Quantitative computed tomography-based finite element analysis (QCT/FEA) has been developed to predict vertebral strength. However, QCT/FEA models may be different with scan resolutions and element sizes. The aim of this study was to explore the effects of scan resolutions and element sizes on QCT/FEA outcomes. Nine bovine vertebral bodies were scanned using the clinical CT...

Treatment of Myocardial Infarction with Gene-modified Mesenchymal Stem Cells in a Small Molecular Hydrogel

• Google Scholar Search for Yongquan Hua in:Nature Research journals • PubMed • Google Scholar Search for Jinliang Li in:Nature Research journals • PubMed • Google Scholar Search for Bei Liu in:Nature ... analysis. Zhiye Wu and Jianwu Zhang complete the cells and animal model construction and cardiac function detection. Yongquan Hua and Bei Liu contributed to samples collection and data statistics. Zhiye Wu

RIePDMA and BP-IDD-IC detection

Pattern division multiple access (PDMA) is a non-orthogonal multiple access (NOMA) scheme which is proposed to meet the demand of massive connection in the future 5G communications. In this paper, we build a random interleaver (RI) enhanced PDMA (RIePDMA) system by bringing the random interleaver into a PDMA system to further improve the overload of PDMA. Furthermore, we analyze...

Targeting inflammasome/IL-1 pathways for cancer immunotherapy

The inflammatory microenvironment has been shown to play important roles in various stages of tumor development including initiation, growth, and metastasis. The inflammasome is a critical innate immune pathway for the production of active IL-1β, a potent inflammatory cytokine. Although inflammasomes are essential for host defense against pathogens and contribute to autoimmune...

Glucose Deficiency Elevates Acid-Sensing Ion Channel 2a Expression and Increases Seizure Susceptibility in Temporal Lobe Epilepsy

Huanfa Li Shan Dong Wei Ma Bei Liu Weiwen Wang Hao Wu Hua Zhang OPEN Brain hypometabolism is a common epilepsy-related finding in both patients and animal models. Fluorodeoxyglucose positron emission

Global Stability of an Epidemic Model of Computer Virus

With the rapid popularization of the Internet, computers can enter or leave the Internet increasingly frequently. In fact, no antivirus software can detect and remove all sorts of computer viruses. This implies that viruses would persist on the Internet. To better understand the spread of computer viruses in these situations, a new propagation model is established and analyzed...

Fetuin-B (FETUB): a Plasma Biomarker Candidate Related to the Severity of Lung Function in COPD

100191, ChinaWen-qi Diao, Ning Shen, Yi-peng Du, Bei-bei Liu, Xiao-yan Sun & Bei HeDepartment of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular ... • PubMed • Google ScholarSearch for Yi-peng Du in:Nature Research journals • PubMed • Google ScholarSearch for Bei-bei Liu in:Nature Research journals • PubMed • Google ScholarSearch for Xiao-yan Sun

High expression of endoplasmic reticulum chaperone grp94 is a novel molecular hallmark of malignant plasma cells in multiple myeloma

Background Multiple myeloma (MM) is a hematologic malignancy that is characterized by the proliferation of abnormal bone marrow plasma cells (BMPC) and overproduction of immunoglobulin or light chains with evidence of end-organ damage such as bone damage, anemia, hypercalcemia, and renal dysfunction. The pathogenesis of MM is closely linked to dysregulated unfolded protein...

Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90

Up to 10% of cytosolic proteins are dependent on the mammalian heat shock protein 90 (HSP90) for folding. However, the interactors of its endoplasmic reticulum (ER) paralogue (gp96, Grp94 and HSP90b1) has not been systematically identified. By combining genetic and biochemical approaches, we have comprehensively mapped the interactome of gp96 in macrophages and B cells. A total...

Production and decays of a light ϕ 0 in the LRTH model under the LHC Higgs data

In this paper we study the production and decays of a light pseudoscalar boson ϕ 0 with m ϕ 0 ≤ m h /2 appeared in the left-right twin Higgs (LRTH) model, and explore its phenomenological consequences when the latest LHC Higgs data are taken into account. We found that (a) the decay rate Br(h → ϕ 0 ϕ 0) can be as large as 80% and can suppress significantly the visible γγ signal...

Tunable integration of absorption-membrane-adsorption for efficiently separating low boiling gas mixtures near normal temperature

Liu, Yong Pan, Bei Liu, Changyu Sun, Xueteng Gao, Lanying Yang, Qinglan Ma & Guangjin ChenState Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu ... competing financial interests. Corresponding authors Correspondence to Bei Liu or Guangjin Chen. Supplementary information PDF files1.Supplementary Information Rights and permissions This work is

The temporal topography of the N-Methyl- N-nitrosourea induced photoreceptor degeneration in mouse retina

Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710032, PR ChinaWei Fang & Bei Liu AuthorsSearch for Ye Tao in:Nature Research journals • PubMed • Google ... • PubMed • Google ScholarSearch for liqiang Wang in:Nature Research journals • PubMed • Google ScholarSearch for Limin Qin in:Nature Research journals • PubMed • Google ScholarSearch for Bei Liu in:Nature

Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8 + T cells without host preconditioning

Background Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. Microbial components, such as LPS, are key mediators of total body irradiation (TBI) enhancement, but our ability to strategically use these toll-like receptor (TLR) agonists to bolster the potency of T cell-based...

Fact or fiction - identifying the elusive multiple myeloma stem cell

Multiple Myeloma (MM) is a debilitating disease of proliferating and malignant plasma cells that is currently incurable. The ability of monoclonal recurrence of disease suggests it might arise from a stem cell-like population capable of self-renewal. The difficulty to isolate the cancer stem-like cell in MM has introduced confusion toward this hypothesis. However, recent evidence...

Prevalence of Veterinary Antibiotics and Antibiotic-Resistant Escherichia coli in the Surface Water of a Livestock Production Region in Northern China

This study investigated the occurrence of 12 veterinary antibiotics (VAs) and the susceptibility of Escherichia coli (E. coli) in a rural water system that was affected by livestock production in northern China. Each of the surveyed sites was determined with at least eight antibiotics with maximum concentration of up to 450 ng L−1. The use of VAs in livestock farming probably was...

Changes in levels of angiotensin II and its receptors in a model of inverted stress-induced cardiomyopathy

Background Stress-induced cardiomyopathy (SIC) has gained increasing attention worldwide and is characterized by extensive ventricular akinesis, Beta-blockers and angiotensin-converting enzyme inhibitors (ACEIs) are the main treatments for SIC patients. The pharmacological mechanism of action of beta-blockers results in the inhibition of the biological effects of catecholamines...

Murine but Not Human Basophil Undergoes Cell-Specific Proteolysis of a Major Endoplasmic Reticulum Chaperone

Introduction Basophil has been implicated in anti-parasite defense, allergy and in polarizing TH2 response. Mouse model has been commonly used to study basophil function although the difference between human and mouse basophils is underappreciated. As an essential chaperone for multiple Toll-like receptors and integrins in the endoplasmic reticulum, gp96 also participates in...