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14 papers found.
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Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study

Zhenzhu Yong,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1 1Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; 2Department of Geriatric

Long non-coding RNA 1308 promotes cell invasion by regulating the miR-124/ADAM 15 axis in non-small-cell lung cancer cells

,3 Yuncang Yuan,1 Tianqi Dong,1 Bei Zhu,1 Lei Wang,1 Fangfang Li,1 Chunyan Yang,1 Dengcai Mu,1 Dan Wang,4 Chunjie Xiao,1 Shangyong Zheng1 1School of Medicine, Yunnan University, Kunming, China

Predictive value of serum cystatin C for acute kidney injury in adults: a meta-analysis of prospective cohort trials

Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu, P.R. ChinaZhenzhu Yong, Xiaohua Pei, Bei Zhu, Haichuan Yuan ...  & Weihong Zhao AuthorsSearch for Zhenzhu Yong in:Nature Research journals • PubMed • Google ScholarSearch for Xiaohua Pei in:Nature Research journals • PubMed • Google ScholarSearch for Bei Zhu in:Nature

Impact of organizational and individual factors on patient-provider relationships: A national survey of doctors, nurses and patients in China

, Liu yi Zhang, Yuan Liang. Data curation: Ping Zhang, Fang Wang, Yao Cheng, Liu yi Zhang, Yuan Liang. Formal analysis: Fang Wang, Bei zhu Ye, Xi Zhu, Yuan Liang. Funding acquisition: Yuan Liang ... . Investigation: Hong wei Jiang, Yi Sun, Xi Zhu. Methodology: Ping Zhang, Yi Sun, Xi Zhu. Project administration: Ping Zhang, Yao Cheng, Xi Zhu, Yuan Liang. Resources: Ping Zhang, Fang Wang, Liu yi Zhang, Bei zhu

Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese

Application of creatinine- and/or cystatin C-based glomerular filtration rate estimation equations in elderly Chinese Xiaoshuang Ye,1 Lu Wei,1 Xiaohua Pei,1 Bei Zhu,1 Jianqing Wu,2 Weihong Zhao1

Comparisons between the 2012 New CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) Equations and Other Four Approved Equations

Objective The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) reported two equations in 2012: one based on cystatin C concentration (CKD-EPI2012cys) and the other using both serum creatinine and cystatin C concentrations (CKD-EPI2012Scr-cys). We compared the adaptability of new formulae with other four equations. Methods Participants (n = 788; median age, 54 [range...

Using Mathematical Algorithms to Modify Glomerular Filtration Rate Estimation Equations

Background The equations provide a rapid and low-cost method of evaluating glomerular filtration rate (GFR). Previous studies indicated that the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease-Epidemiology (CKD-EPI) and MacIsaac equations need further modification for application in Chinese population. Thus, this study was designed to modify the three...

Effects of cyclin-dependent kinase 8 specific siRNA on the proliferation and apoptosis of colon cancer cells

Background To investigate the expression of cyclin-dependent kinase 8 (CDK8) and β-catenin in colon cancer and evaluate the role of CDK8 in the proliferation, apoptosis and cell cycle progression of colon cancer cells, especially in HCT116 cell line. Methods Colon cancer cell line HCT116 was transfected with small interfering RNA (siRNA) targeting on CDK8. After CDK8-siRNA...

An Integrated Meta-Analysis of Two Variants in HOXA1/HOXB1 and Their Effect on the Risk of Autism Spectrum Disorders

Background HOXA1 and HOXB1 have been strongly posed as candidate genes for autism spectrum disorders (ASD) given their important role in the development of hindbrain. The A218G (rs10951154) in HOXA1 and the insertion variant in HOXB1 (nINS/INS, rs72338773) were of special interest for ASD but with inconclusive results. Thus, we conducted a meta-analysis integrating case-control...

Deficiency of a novel mismatch repair activity in a bladder tumor cell line

We demonstrate here that a cell line derived from a bladder cancer is defective in strand-specific mismatch repair. The mismatch repair deficiency in this cell line is associated with microsatellite instability and blocks an early step in the repair pathway. Since the addition of a known mismatch repair component hMutSα, hMutSβ, hMutLα, replication protein A or proliferating...

Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Patients with Alzheimer's disease (AD) exhibit higher levels of 8-oxo-guanine (8-oxoG) DNA lesions in their brain, suggesting a reduced or defective 8-oxoG repair. To test this hypothesis, this study investigated 14 AD patients and 10 age-matched controls for mutations of the major 8-oxoG removal gene OGG1. Whereas no alterations were detected in any control samples, four AD...

Interactions between Genetic Variants in the Adiponectin, Adiponectin Receptor 1 and Environmental Factors on the Risk of Colorectal Cancer

Background Metabolic syndrome traits play an important role in the development of colorectal cancer. Adipokines, key metabolic syndrome cellular mediators, when abnormal, may induce carcinogenesis. Methodology/Principal Findings To investigate whether polymorphisms of important adipokines, adiponectin (ADIPOQ) and its receptors, either alone or in combination with environmental...

In vitro and in vivo modulations of benzo[c]phenanthrene–DNA adducts by DNA mismatch repair system

Benzo[c]phenanthrene dihydrodiol epoxide (B[c] PhDE) is well known as an important environmental chemical carcinogen that preferentially modifies DNA in adenine residues. However, the molecular mechanism by which B[c]PhDE induces tumorigenesis is not fully understood. In this report, we demonstrate that DNA mismatch repair (MMR), a genome maintenance system, plays an important...

gp130‐linked signal transduction promotes the differentiation and maturation of dendritic cells

In order to explore the role of gp130‐linked signal transduction in the differentiation and maturation of dendritic cells (DC), the mAb, B‐S12, an agonist of gp130, was used for the activation of gp130 on DC. The effects of cytokines and of anti‐gp130 mAb on the proliferation of DC, and their expression of IL‐12 and CD80 (B7‐1) by DC were evaluated. DC differentiating from...