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Detection of DNA Amplicons of Polymerase Chain Reaction Using Litmus Test

of Canada (NSERC). Author information AffiliationsDepartment of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St. W., Hamilton, ON L8S 4K1, CanadaDingran Chang, Ben Li, Zhifa ... • Google Scholar Search for Kha Tram in:Nature Research journals • PubMed • Google Scholar Search for Ben Li in:Nature Research journals • PubMed • Google Scholar Search for Qian Feng in:Nature Research

Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

addressed to Luan Xue; moc.361@oclex Received 27 February 2017; Revised 5 May 2017; Accepted 5 June 2017; Published 10 July 2017 Academic Editor: Lesley Ward Copyright © 2017 Ben Li et al. This is an open

Fine Mapping of Two Additive Effect Genes for Awn Development in Rice (Oryza sativa L.)

Awns, important domestication and agronomic traits in rice (Oryza sativa L.), are conferred by polygenes and the environment. Near isogenic line (NIL) pairs BM33 and BM38 were constructed from crosses between awnless japonica cv Nipponbare as recurrent parent, and lines SLG or Funingxiaohongmang (awned japonica accessions), respectively, as donors. In order to study the genetic...

Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates

DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Recent developments in whole genome bisulfite sequencing (WGBS) technology have enabled genome-wide measurements of DNA methylation at single base pair resolution. Many experiments have been conducted to compare DNA methylation profiles under different biological contexts...

Reliability of environmental sampling culture results using the negative binomial intraclass correlation coefficient

The Intraclass Correlation Coefficient (ICC) is commonly used to estimate the similarity between quantitative measures obtained from different sources. Overdispersed data is traditionally transformed so that linear mixed model (LMM) based ICC can be estimated. A common transformation used is the natural logarithm. The reliability of environmental sampling of fecal slurry on...

Assessment of Carotid Arterial Wall Elasticity in Type 2 Diabetes Mellitus Patients with Microalbuminuria by Real-Time Ultrasound Elastography

The aim of this study was to evaluate carotid arterial wall elasticity in type 2 diabetes mellitus (T2DM) with microalbuminuria by real-time ultrasound elastography. Two hundred and ten T2DM patients were divided into two groups according to levels of urinary albumin excretion (UAE): T2DM without microalbuminuria (T2DM1 group, 120) and T2DM with microalbuminuria (T2DM2 group, 90...

Direct Amplification, Sequencing and Profiling of Chlamydia trachomatis Strains in Single and Mixed Infection Clinical Samples

Sequencing bacterial genomes from DNA isolated directly from clinical samples offers the promise of rapid and precise acquisition of informative genetic information. In the case of Chlamydia trachomatis, direct sequencing is particularly desirable because it obviates the requirement for culture in mammalian cells, saving time, cost and the possibility of missing low abundance...

Assessment of Carotid Atherosclerosis in Type 2 Diabetes Mellitus Patients with Microalbuminuria by High-Frequency Ultrasonography

The aim of this study is to evaluate carotid atherosclerosis in patients of type 2 diabetes mellitus with microalbuminuria (MA) by high-frequency ultrasonography. Two hundred and fifty patients of type 2 diabetes mellitus were divided into two groups according to urinary albumin excretion rate (UAER): normoalbuminuria group (130 cases) and microalbuminuria group (120 cases). The...

Base-resolution methylation patterns accurately predict transcription factor bindings in vivo

Detecting in vivo transcription factor (TF) binding is important for understanding gene regulatory circuitries. ChIP-seq is a powerful technique to empirically define TF binding in vivo. However, the multitude of distinct TFs makes genome-wide profiling for them all labor-intensive and costly. Algorithms for in silico prediction of TF binding have been developed, based mostly on...

Fecal bacterial microbiome diversity in chronic HIV-infected patients in China

Jun Cheng Jiashen Shao Tangkai Qi Yan Tang Rentian Cai Liqian Guan Bin Luo Meiyan Sun Ben Li Zhiheng Pei Hongzhou Lu The purpose of this study was to identify fecal bacterial microbiome changes in

Seasonal changes in expression of nerve growth factor and its receptors TrkA and p75 in the ovary of wild ground squirrel (Citellus dauricus Brandt)

The aim of this study was to investigate the presence of nerve growth factor (NGF) and its receptors tyrosine kinase A (TrkA) and p75 in the ovaries of the wild ground squirrels during the breeding and nonbreeding seasons. In the breeding period, NGF, TrkA and p75 were immunolocalized in granulosa cells, thecal cells, interstitial cells and luteal cells whereas in the nonbreeding...

Immunoreactivities of androgen receptor, estrogen receptors, p450arom, p450c17 proteins in wild ground squirrels ovaries during the nonbreeding and breeding seasons

The aim of this study was to elucidate the regulatory role of androgen in the follicular development of wild female ground squirrels. Immunohistochemical staining of FSHR, LHR, P450c17, P450arom, androgen receptor (AR), estrogen receptors (ERa and ERb) were executed in ovaries of female ground squirrels from both breeding and nonbreeding seasons. In addition, total ovarian...

Fine mapping of the awn gene on chromosome 4 in rice by association and linkage analyses

Awnness is a key trait in rice domestication, yet no studies have been conducted on fine mapping or association mapping of the rice awn gene. In this study, we investigated the awnness and genotype of a core collection of 303 cultivated rice varieties and a BC5F2 segregating population of 200 individuals. Combining association and linkage analyses, we mapped the awnness related...

Focal facial dermal dysplasia, type IV, is caused by mutations in CYP26C1

Focal facial dermal dysplasia (FFDD) Type IV is a rare syndrome characterized by facial lesions resembling aplasia cutis in a preauricular distribution along the line of fusion of the maxillary and mandibular prominences. To identify the causative gene(s), exome sequencing was performed in a family with two affected siblings. Assuming autosomal recessive inheritance, two novel...

Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling

The primary biological function of the endogenous cellular prion protein has remained unclear. We investigated its biological function in the generation of cellular immune responses using cellular prion protein gene-specific small interfering ribonucleic acid in vivo and in vitro. Our results were confirmed by blocking cellular prion protein with monovalent antibodies and by...