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Optical clearing potential of immersion-based agents applied to thick mouse brain sections

California, Irvine) for their intellectual contributions to this project. Author Contributions Conceptualization: Christian Crouzet, Vitaly Vasilevko, Bernard Choi. Data curation: Mathew Loren, Bernard Choi ... . Formal analysis: Mathew Loren, Christian Crouzet, Adrian Bahani, Bernard Choi. Funding acquisition: Bernard Choi. Investigation: Mathew Loren, Christian Crouzet, Adrian Bahani. Methodology: Mathew Loren

An International Comparison of Women's Health Issues in the Philippines, Thailand, Malaysia, Canada, Hong Kong, and Singapore: The CIDA-SEAGEP Study

This was an international study of women’'s health issues, based on an Official Study Tour in Southeast Asia (the Philippines, Thailand, Malaysia, Hong Kong, and Singapore) and Canada. The objectives of the study were to identify and compare current gaps in surveillance, research, and programs and policies, and to predict trends of women’

Bridging the gap between science and policy: an international survey of scientists and policy makers in China and Canada

Background Bridging the gap between science and policy is an important task in evidence-informed policy making. The objective of this study is to prioritize ways to bridge the gap. Methods The study was based on an online survey of high-ranking scientists and policy makers who have a senior position in universities and governments in the health sector in China and Canada. The...

Optical Histology: A Method to Visualize Microvasculature in Thick Tissue Sections of Mouse Brain

Background The microvasculature is the network of blood vessels involved in delivering nutrients and gases necessary for tissue survival. Study of the microvasculature often involves immunohistological methods. While useful for visualizing microvasculature at the µm scale in specific regions of interest, immunohistology is not well suited to visualize the global microvascular...

APP Knockout Mice Experience Acute Mortality as the Result of Ischemia

The incidence of Alzheimer’s disease increases in people who have had an ischemic episode. Furthermore, APP expression is increased following ischemic or hypoxic conditions, as is the production of the Aβ peptide. To address the question of why APP and Aβ are increased in hypoxic and ischemic conditions we induced an ischemic episode in APP knockout mice (APP−/−) and BACE1...

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

antifibrinolytic intervention in laser-treated, partially occluded PWS vasculature. Bernard Choi and Kristen M. Kelly acknowledge PHSNIH for financial support through the Child Health & Human Development Award