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„Diabesity“ – Adipositas und Typ-2-Diabetes (Update 2019)

ZusammenfassungAdipositas und Typ-2-Diabetes werden seit einigen Jahren vermehrt unter dem Namen „Diabesity“ zusammengefasst. Das trägt dem Umstand Rechnung, dass die Adipositas dem Diabetes in den meisten Fällen häufig vorangeht und wohl der wichtigste Faktor in der weltweiten Zunahme des Typ-2-Diabetes ist. Der Body-Mass-Index (BMI) ist individuell betrachtet ein sehr grobes Ma...

Ernährungsempfehlungen bei Diabetes mellitus (Update 2019)

ZusammenfassungEs besteht breiter Konsens, dass eine effiziente Diabetes-Therapie in den meisten Fällen auch von einer Modifikation des Lebensstils begleitet sein muss. Das bedeutet für die Patienten in der Regel eine Normalisierung des Körpergewichts (Gewichtsreduktion und/oder Halten des Gewichts) in Kombination mit einer Veränderung des Bewegungs- und Ernährungsverhaltens.Die...

Changes in Bone Mineral Density Following Weight Loss Induced by One-Anastomosis Gastric Bypass in Patients with Vitamin D Supplementation

& Eva Winzer 2,3 & Karin Schindler 1 & Igor Grabovac 3 & Franz Kainberger 5 & Michael Krebs 1 & Friedrich Hoppichler 2,6 & Felix Langer 7 & Gerhard Prager 7 & Rodrig Marculescu 8 & Bernhard Ludvik 1,9

Antihyperglykämische Therapie bei Diabetes mellitus Typ 2 (Update 2019)

Unternehmen, die auch fördernde Mitglieder der ÖDG sind, Honorare für Vorträge und Advisory Boards erhalten: Boehringer, Novo, Sanofi. Bernhard Ludvik hat von folgenden Unternehmen, die auch fördernde

Management of Pregnant Women after Bariatric Surgery

Bernhard Ludvik,2,5 Anton Luger,2 Alexandra Kautzky-Willer,1 and Michael Krebs2 1Gender Medicine Unit, Division of Endocrinology and Metabolism, Department of Medicine III, Medical University Vienna, Vienna

Adipositas und Typ 2 Diabetes

Adipositas und Typ 2 Diabetes werden heute gerne unter dem Namen „Diabesity“ zusammengefasst. Das trägt dem Umstand Rechnung, dass die Adipositas dem Diabetes häufig vorangeht und wohl der wichtigste Faktor in der Zunahme des Typ 2 Diabetes mellitus ist. Der Body-Mass-Index (BMI) ist nur ein sehr grobes Maß der Körperverfettung. Sogar Normalgewichtige können bei Muskelmangel zu...

Vitamin D3 Loading Is Superior to Conventional Supplementation After Weight Loss Surgery in Vitamin D-Deficient Morbidly Obese Patients: a Double-Blind Randomized Placebo-Controlled Trial

Background Bariatric patients often suffer from vitamin D deficiency (VDD), and both, morbid obesity and VDD, are related to non-alcoholic fatty liver disease. However, limited data are available regarding best strategies for treating VDD, particularly, in bariatric patients undergoing omega-loop gastric bypass (OLGB). Therefore, we examined the efficacy and safety of a forced...

The Effect of Roux-en-Y vs. Omega-Loop Gastric Bypass on Liver, Metabolic Parameters, and Weight Loss

Background Omega-loop gastric bypass (OLGB) results in weight loss (WL) but data on its impact on liver and glucose metabolism compared to Roux-en-Y gastric bypass (RYGB) is lacking. Therefore, the aim of this study was to compare the development of hepatic and metabolic markers as well as WL between the above-mentioned surgical groups during the first postoperative year. Methods...

Prevalence of Liver Fibrosis and its Association with Non-invasive Fibrosis and Metabolic Markers in Morbidly Obese Patients with Vitamin D Deficiency

of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna , Vienna , Austria 2 Bernhard Ludvik 3 1st Department of Medicine and Karl Landsteiner Institute for

Detecting Body Fat–A Weighty Problem BMI versus Subcutaneous Fat Patterns in Athletes and Non-Athletes

We aimed to describe the relationship between BMI and the subcutaneous adipose tissue topography within young athletes and non-athletic controls, to comparatively evaluate the diagnostic powers of subcutaneous adipose tissue thicknesses at different body sites, furthermore to explore appropriate cut-offs to discriminate between athletes and controls. Measurements were determined...

The link between obesity and vitamin D in bariatric patients with omega-loop gastric bypass surgery - a vitamin D supplementation trial to compare the efficacy of postoperative cholecalciferol loading (LOAD): study protocol for a randomized controlled trial

Background Beyond its classical role in calcium homoeostasis and bone metabolism, vitamin D deficiency has been found to be associated with several diseases, including diabetes, non-alcoholic fatty liver disease, and even obesity itself. Importantly, there are limited data on therapeutic strategies for vitamin D deficiency in bariatric patients, and the procedure-specific...

Alterations in Gastrointestinal, Endocrine, and Metabolic Processes After Bariatric Roux-en-Y Gastric Bypass Surgery

OBJECTIVE Obesity leads to severe long-term complications and reduced life expectancy. Roux-en-Y gastric bypass (RYGB) surgery induces excessive and continuous weight loss in (morbid) obesity, although it causes several abnormal anatomical and physiological conditions.

Efficacy of Ipomoea batatas (Caiapo) on Diabetes Control in Type 2 Diabetic Subjects Treated With Diet

OBJECTIVE—To investigate the tolerability, efficacy, and mode of action of Caiapo, an extract of white sweet potatoes, on metabolic control in type 2 diabetic patients. RESEARCH DESIGN AND METHODS—A total of 61 type 2 diabetic patients treated by diet were given 4 g Caiapo (n = 30; mean age 55.2 ± 2.1 years; BMI 28.0 ± 0.4 kg/m2) or placebo (n = 31; mean age 55.6 ± 1.5 years; BMI...

Cholinergic Regulation of Ghrelin and Peptide YY Release May Be Impaired in Obesity

Christina Maier Michaela Riedl Greisa Vila Peter Nowotny Michael Wolzt Martin Clodi Bernhard Ludvik Anton Luger OBJECTIVE-Ghrelin and peptide YY (PYY) are both hormones derived from the

Austrian Lipid Consensus on the management of metabolic lipid disorders to prevent vascular complications

In 2010, eight Austrian medical societies proposed a joint position statement on the management of metabolic lipid disorders for the prevention of vascular complications. An updated and extended version of these recommendations according to the current literature is presented, referring to the primary and secondary prevention of vascular complications in adults, taking into...

A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test

OBJECTIVE—Available insulin sensitivity (IS) methods based on the oral glucose tolerance test (OGTT) are empirical. We used a glucose-insulin model to derive an OGTT-based IS (oral glucose insulin sensitivity [OGIS]) index, which predicts glucose clearance in a glucose clamp. We validated OGIS against clamp data. RESEARCH DESIGN AND METHODS—OGIS requires glucose and insulin...

The Clamp-Like Index: A novel and highly sensitive insulin sensitivity index to calculate hyperinsulinemic clamp glucose infusion rates from oral glucose tolerance tests in nondiabetic subjects

OBJECTIVE—Insulin resistance, the underlying pathophysiological mechanism of the metabolic syndrome, can not only predict type 2 diabetes development but also cardiovascular disease. Thus, precise insulin resistance measurement in individuals at risk for metabolic diseases would support clinical risk stratification. However, the gold standard for measuring insulin resistance, the...

Are there differences in LDL-C target value attainment in Austrian federal states? Yes!

Low density lipoprotein (LDL-C) levels determine the cardiovascular risk. Previous studies indicated an LDL-C target attainment of around 50 %, but no Austrian wide analysis on results for the federal states was available. We therefore sought to detect potential differences. Design: Open-label, non-interventional, longitudinal study, registered: www.​clinicaltrials.​gov NCT...