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PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus

Yan Liu 0 Bin Yi 0 Farid Nakhoul Monika A. Niewczas 0 Department of Nephrology, The Third Xiangya Hospital of Central South University , 138 Tongzipo Road, Changsha, Hunan , China 1 Diabetic Nephropathy

PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus

Objective. Inflammation plays a major role in albuminuria in type 2 diabetes mellitus (T2DM). Our previous studies have shown that the expression of vitamin D receptor (VDR) is downregulated in T2DM which is closely associated with the severity of albuminuria. In this study, we investigated the expression of anti-inflammatory cytokine protein tyrosine phosphatase nonreceptor type...

Oral microbial community assembly under the influence of periodontitis

Chen, Shuting Peng, Bin Yi, Zhanshan (Sam) Ma. Investigation: Lin Dai, Quan Zou, Xianghong Yang. Methodology: Hongju Chen, Zhanshan (Sam) Ma. Writing ± original draft: Hongju Chen, Zhanshan (Sam) Ma

The ET-1-mediated carbonylation and degradation of ANXA1 induce inflammatory phenotype and proliferation of pulmonary artery smooth muscle cells in HPS

Supporting Information files. Funding: This work is supported by grant nos. 81670552 (Bin Yi) and 81600035 (Yang Chen) from the National Science Foundation of China (NSFC) and cstc2016jcyjA0120 (Bin Yi) from

Genetic effects and genotype × environment interactions govern seed oil content in Brassica napus L.

Background As seed oil content (OC) is a key measure of rapeseed quality, better understanding the genetic basis of OC would greatly facilitate the breeding of high-oil cultivars. Here, we investigated the components of genetic effects and genotype × environment interactions (GE) that govern OC using a full diallel set of nine parents, which represented a wide range of the...

Mechanistic Role of MicroRNA in Cancer Chemoprevention by Nonsteroidal Anti-inflammatory Drugs

Yaguang Xi). We sincerely apologize to those whose work was not cited due to time and space constraints. Compliance with Ethics Guidelines Conflict of Interest Ruixia Ma, Bin Yi, Gary A. Piazza, and

Circulating miR-106a is a Novel Prognostic and Lymph Node Metastasis Indicator for Cholangiocarcinoma

Cholangiocarcinoma (CCA) is a common biliary malignancy. Despite continuing advances, novel indicators are urgently needed to identify patients with a poor prognosis. Several microRNAs (miRNAs) have been reported to be dysregulated in CCA tissues. The purpose of the current study was to explore the potential use of certain miRNAs as serum indicators. A total of 157 individuals...

High expression of GNA13 is associated with poor prognosis in hepatocellular carcinoma

Guanine nucleotide binding protein alpha 13 (GNA13) has been found to play critical roles in the development of several human cancers. However, little is known about GNA13 expression and its clinical significance in hepatocellular carcinoma (HCC). In our study, GNA13 was reported to be significantly up-regulated in HCC tissues, and this was correlated with several...

Chemical Analysis of the Chinese Liquor Luzhoulaojiao by Comprehensive Two-Dimensional Gas Chromatography/Time-of-Flight Mass Spectrometry

, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of ChinaYumin Liu AuthorsSearch for Feng Yao in:Nature Research journals • PubMed • Google ScholarSearch for Bin Yi in:Nature Research

Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis

Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis Qingbao Cheng,* Bin Yi,* Aihua Wang,* Xiaoqing Jiang Eastern Hepatobiliary Surgery Hospital, Second Military Medical

A bi-filtering method for processing single nucleotide polymorphism array data improves the quality of genetic map and accuracy of quantitative trait locus mapping in doubled haploid populations of polyploid Brassica napus

Background Single nucleotide polymorphism (SNP) markers have a wide range of applications in crop genetics and genomics. Due to their polyploidy nature, many important crops, such as wheat, cotton and rapeseed contain a large amount of repeat and homoeologous sequences in their genomes, which imposes a huge challenge in high-throughput genotyping with sequencing and/or array...

Effects of long-term salicylate administration on synaptic ultrastructure and metabolic activity in the rat CNS

, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai ChinaYufei Ma AuthorsSearch for Bin Yi in:Nature Research journals • PubMed • Google ScholarSearch for Shousen Hu in:Nature

A Complex Recombination Pattern in the Genome of Allotetraploid Brassica napus as Revealed by a High-Density Genetic Map

Polyploidy plays a crucial role in plant evolution. Brassica napus (2n = 38, AACC), the most important oil crop in the Brassica genus, is an allotetraploid that originated through natural doubling of chromosomes after the hybridization of its progenitor species, B. rapa (2n = 20, AA) and B. oleracea (2n = 18, CC). A better understanding of the evolutionary relationship between B...

RNA-Seq for gene identification and transcript profiling of three Stevia rebaudiana genotypes

Background Stevia (Stevia rebaudiana) is an important medicinal plant that yields diterpenoid steviol glycosides (SGs). SGs are currently used in the preparation of medicines, food products and neutraceuticals because of its sweetening property (zero calories and about 300 times sweeter than sugar). Recently, some progress has been made in understanding the biosynthesis of SGs in...

Annexin A1 protein regulates the expression of PMVEC cytoskeletal proteins in CBDL rat serum-induced pulmonary microvascular remodeling

Background Hepatopulmonary syndrome (HPS) is characterized by advanced liver disease, hypoxemia and intrapulmonary vascular dilatation (IPVD). The pathogenesis of HPS is not completely understood. Recent findings have established the role of proliferation and phenotype differentiation of pulmonary microvascular endothelial cells (PMVECs) in IPVD of HPS; the change in cytoskeletal...

Unravelling the complex trait of harvest index in rapeseed (Brassica napus L.) with association mapping

Background Harvest index (HI), the ratio of grain yield to total biomass, is considered as a measure of biological success in partitioning assimilated photosynthate to the harvestable product. While crop production can be dramatically improved by increasing HI, the underlying molecular genetic mechanism of HI in rapeseed remains to be shown. Results In this study, we examined the...

Nuclear NF-κB p65 in Peripheral Blood Mononuclear Cells Correlates with Urinary MCP-1, RANTES and the Severity of Type 2 Diabetic Nephropathy

Aims To investigate if nuclear NF-κB p65 expression in ex vivo isolated peripheral blood mononuclear cells correlates with urinary MCP-1 or RANTES and the severity of type 2 diabetic nephropathy. Methods According to their urinary albumin-to-creatinine ratio (uACR), 107 patients with type 2 diabetes (eGFR >60 ml/min) were divided into normal albuminuria group (DN0 group, 38 cases...

Comparative transcript profiling of the fertile and sterile flower buds of pol CMS in B. napus

Background The Polima (pol) system of cytoplasmic male sterility (CMS) and its fertility restoration gene Rfp have been used in hybrid breeding in Brassica napus, which has greatly improved the yield of rapeseed. However, the mechanism of the male sterility transition in pol CMS remains to be determined. Results To investigate the transcriptome during the male sterility...

Ambra1 Is an Essential Regulator of Autophagy and Apoptosis in SW620 Cells: Pro-Survival Role of Ambra1

Recent research has revealed a role for Ambra1, an autophagy-related gene-related (ATG) protein, in the autophagic pro-survival response, and Ambra1 has been shown to regulate Beclin1 and Beclin1-dependent autophagy in embryonic stem cells. However, whether Ambra1 plays an important role in the autophagy pathway in colorectal cancer cells is unknown. In this study, we...

A High-Density SNP Map for Accurate Mapping of Seed Fibre QTL in Brassica napus L

A high density genetic linkage map for the complex allotetraploid crop species Brassica napus (oilseed rape) was constructed in a late-generation recombinant inbred line (RIL) population, using genome-wide single nucleotide polymorphism (SNP) markers assayed by the Brassica 60 K Infinium BeadChip Array. The linkage map contains 9164 SNP markers covering 1832.9 cM. 1232 bins...