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Identifying critical edges in complex networks

The critical edges in complex networks are extraordinary edges which play more significant role than other edges on the structure and function of networks. The research on identifying critical edges in complex networks has attracted much attention because of its theoretical significance as well as wide range of applications. Considering the topological structure of networks and...

Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement

, and this effect may be mediated by activation of the RhoA/ROCK1 pathway. KeywordsPEDF Actin RhoA/ROCK1 Proteinuria Diabetic kidney disease  Jiongyu Hu and Bing Chen have contributed equally to this

Sense-antisense gene overlap is probably a cause for retaining the few introns in Giardia genome and the implications

It is widely accepted that the last eukaryotic common ancestor and early eukaryotes were intron-rich and intron loss dominated subsequent evolution, thus the presence of only very few introns in some modern eukaryotes must be the consequence of massive loss. But it is striking that few eukaryotes were found to have completely lost introns. Despite extensive research, the causes...

Progress in mesenchymal stem cell–based therapy for acute liver failure

Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. The only curative treatment for acute liver failure is liver transplantation, but there are...

Stability Analysis for a Class of Discrete-Time Nonhomogeneous Markov Jump Systems with Multiplicative Noises

This paper is concerned with a class of discrete-time nonhomogeneous Markov jump systems with multiplicative noises and time-varying transition probability matrices which are valued on a convex polytope. The stochastic stability and finite-time stability are considered. Some stability criteria including infinite matrix inequalities are obtained by parameter-dependent Lyapunov...

Recognizing spatial and temporal clustering patterns of dengue outbreaks in Taiwan

Dengue fever is the most common arboviral infection in humans, with viral transmissions occurring in more than 100 countries in tropical regions. A global strategy for dengue prevention and control was established more than 10 years ago. However, the factors that drive the transmission of the dengue virus and subsequent viral infection continue unabated. The largest dengue...

Comparison of outcomes in hematological malignancies treated with haploidentical or HLA-identical sibling hematopoietic stem cell transplantation following myeloablative conditioning: A meta-analysis

: Dan Guo, Peipei Xu. Project administration: Bing Chen. Software: Dan Guo, Peipei Xu. Writing ± original draft: Dangui Chen, Bing Chen. Writing ± review & editing: Dangui Chen, Di Zhou, Bing Chen

Effective real-time forecasting of inundation maps for early warning systems during typhoons

Accurate forecasts of hourly inundation depths are essential for inundation warning and mitigation during typhoons. In this paper, an effective forecasting model is proposed to yield 1- to 6-h lead-time inundation maps for early warning systems during typhoons. The proposed model based on Support Vector Machine (SVM) is composed of two modules, point forecasting and spatial...

Leptin resistance was involved in susceptibility to overweight in the striped hamster re-fed with high fat diet

partly funded the State Key Laboratory of Integrated Management of Pest Insects and Rodents (no. ChineseIPM1704). Author information Author notes Ying Zhao and Li-Bing Chen contributed equally to this ... work. AffiliationsCollege of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, ChinaYing Zhao, Li-Bing Chen, Si-Si Mao, Hong-Xia Min & Jing Cao AuthorsSearch for Ying Zhao in:Nature

The Benefits of Residual Hair Cell Function for Speech and Music Perception in Pediatric Bimodal Cochlear Implant Listeners

, CA, USA Correspondence should be addressed to Yilai Shu; nc.ude.naduf@uhs_ialiy and Bing Chen; nc.ude.naduf@nehcgnib Received 27 December 2017; Accepted 13 March 2018; Published 15 April 2018

Characteristics and mutation analysis of Ph-positive leukemia patients with T315I mutation receiving tyrosine kinase inhibitors

Peng 1 Bing chen 0 0 Department of h ematology, n anjing Drum Tower h ospital c linical c ollege of n anjing Medical University , n anjing, People's republic of china 1 Department of h ematology, Drum

Efficacy and long-term longitudinal follow-up of bone marrow mesenchymal cell transplantation therapy in a diabetic patient with recurrent lower limb bullosis diabeticorum

Bullosis diabeticorum is a rare presentation of cutaneous manifestation most commonly affecting the lower limbs in patients with diabetes. The appearance, often as insidious as its resolution, is characterized by tense blisters on the skin surfaces of the lower limbs and the feet. The cause still remains unclear, but it may relate to microangiopathy and neuropathy. In this report...

TP53 mutation predicts the poor prognosis of non-Hodgkin lymphomas: Evidence from a meta-analysis

Non-Hodgkin lymphoma (NHL) is a group of malignant hematologic disorders with high heterogeneity. The diagnosis, clinical manifestations, classification, and prognosis of this condition differ among numerous NHL subgroups. The prognostic significance of the mutation of TP53, a tumor suppressor gene involved in cell cycle regulation, should be confirmed in NHL. In this study, our...

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity

; wt.gro.hcc@932701 and Wen-Hung Chung; moc.oohay@gnuhcgnuhnew Received 1 September 2017; Accepted 9 November 2017; Published 13 February 2018 Academic Editor: Kurt Blaser Copyright © 2018 Chun-Bing Chen et

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity

; wt.gro.hcc@932701 and Wen-Hung Chung; moc.oohay@gnuhcgnuhnew Received 1 September 2017; Accepted 9 November 2017; Published 13 February 2018 Academic Editor: Kurt Blaser Copyright © 2018 Chun-Bing Chen et

A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in cancerous processes as either oncogenes or tumor suppressor genes. Here, we demonstrated that lncRNA-PRLB (progression-associated lncRNA in breast cancer) was upregulated in human breast cancer tissues and breast cancer cell lines. Further evaluation verified that lncRNA-PRLB was...

Treatment of pretibial myxedema with intralesional immunomodulating therapy

Treatment of pretibial myxedema with intralesional immunomodulating therapy Ziwei Ren,1,* Min He,2,* Fang Deng,2 Yan Chen,1 Liyin Chai,1 Bing Chen,2 Wuquan Deng1 1Department of Endocrinology and

Mesenchymal Stem Cells as a Prospective Therapy for the Diabetic Foot

The diabetic foot is a serious complication of diabetes. Mesenchymal stem cells are an abundant source of stem cells which occupy a special position in cell therapies, and recent studies have suggested that mesenchymal stem cells can play essential roles in treatments for the diabetic foot. Here, we discuss the advances that have been made in mesenchymal stem cell treatments for...

Mesenchymal Stem Cells as a Prospective Therapy for the Diabetic Foot

The diabetic foot is a serious complication of diabetes. Mesenchymal stem cells are an abundant source of stem cells which occupy a special position in cell therapies, and recent studies have suggested that mesenchymal stem cells can play essential roles in treatments for the diabetic foot. Here, we discuss the advances that have been made in mesenchymal stem cell treatments for...