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Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition

the manuscript. All authors read and approved the final manuscript. Author information Author notes These authors contributed equally: Bo Jing, Jin Jin. AffiliationsKey Laboratory of Cell ... Medicine, 200011, Shanghai, ChinaYin Tong, Xinhua Xiao & Wei Liu AuthorsSearch for Bo Jing in:Nature Research journals • PubMed • Google Scholar Search for Jin Jin in:Nature Research journals • PubMed

Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis

Psoriatic keratinocytes express exaggerated levels of inflammatory cytokines, and show aberrant hyperproliferation and terminal differentiation in the pathogenesis of psoriasis. The antimicrobial protein hS100A7 (psoriasin) has been found highly expressed in psoriatic skin, but the mechanism and physiological function remain largely unknown. We observed that hS100A7 induces...

Adaptive Neural Control of Nonaffine Nonlinear Systems without Differential Condition for Nonaffine Function

An adaptive neural control scheme is proposed for nonaffine nonlinear system without using the implicit function theorem or mean value theorem. The differential conditions on nonaffine nonlinear functions are removed. The control-gain function is modeled with the nonaffine function probably being indifferentiable. Furthermore, only a semibounded condition for nonaffine nonlinear...

Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens

Increasing studies have focused on the beneficial effects of Lactobacillus johnsonii in certain diseases. Here, we studied the prevention ability of a probiotic strain, L. johnsonii BS15 on subclinical necrotic enteritis (SNE), and its underlying mechanism. 180 male Cobb 500 chicks were randomly allotted into three groups and administrated with BS15 (1 × 106 cfu/g) or Man Rogosa...

Molecular cloing and bioinformatics analysis of lactate dehydrogenase from Taenia multiceps

Coenurus cerebralis, the larval stage (metacestode or coenurus) of Taenia multiceps, parasitizes sheep, goats, and other ruminants and causes coenurosis. In this study, we isolated and characterized complementary DNAs that encode lactate dehydrogenase A (Tm-LDHA) and B (Tm-LDHB) from the transcriptome of T. multiceps and expressed recombinant Tm-LDHB (rTm-LDHB) in Escherichia...

Prevalence and multilocus genotyping of Giardia duodenalis in dairy calves in Xinjiang, Northwestern China

Background Giardia duodenalis is an important protozoan parasite. It is an established zoonotic pathogen and dairy calves have been implicated as one of the most important sources of human infection. This study was conducted to assess the prevalence and multilocus genotyping of G. duodenalis in dairy calves in the Xinjiang Uyghur Autonomous Region, northwestern China. Findings A...

Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity

, glycosaminoglycan; GO, gene ontology; KEGG, Kyoto encyclopedia of genes and genomes; N-DMP1, DMP1N-terminal; NSC, neural stem cell; PG, proteoglycan; COMPLIANCE WITH ETHICS GUIDELINES Bo Jing, Chunxue Zhang

Microbial community compositions in the gastrointestinal tract of Chinese Mongolian sheep using Illumina MiSeq sequencing revealed high microbial diversity

Chinese Mongolian sheep are an important ruminant raised for wool and meat production. However, little is known about the microbiota of the gastrointestinal tract (GIT) of Chinese Mongolian sheep. To increase our understanding of the microbial community composition in the GIT of Chinese Mongolian sheep, microbiota of five sheep is investigate for the first time using the Illumina...

Fatty-binding protein and galectin of Baylisascaris schroederi: Prokaryotic expression and preliminary evaluation of serodiagnostic potential

Lan, Zhihe Zhang. Software: Yiran Wu. Supervision: Bo Jing, Xiaobing Gu, Yue Xie, Weimin Lai, Xuerong Peng. Visualization: Lang Xiong. Writing ± original draft: Ying Sun. Writing ± review & editing

Effects of Bacillus licheniformis on the growth performance and expression of lipid metabolism-related genes in broiler chickens challenged with Clostridium perfringens-induced necrotic enteritis

Background Necrotic enteritis (NE), caused by Clostridium perfringens, has cost the poultry industry $2 billion in losses. This study aimed to investigate the effect of Bacillus licheniformis as dietary supplement on the growth, serum antioxidant status, and expression of lipid-metabolism genes of broiler chickens with C. perfringens-induced NE. Methods A total of 240 one-day-old...

Complete genome sequence of the novel duck hepatitis B virus strain SCP01 from Sichuan Cherry Valley duck

Background The duck hepatitis B virus (DHBV) strain, designated SCP01, was isolated and identified from a Sichuan Cherry Valley duck in Southwestern China. To determine the origination and evolution of this isolated strain, we carried out complete genome sequencing of this strain. Findings Sequencing of the nucleotide sequence of DHBV strain SCP01 revealed a genome size of 3021...

Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis

Zhongshuang Liu in:Nature Research journals • PubMed • Google ScholarSearch for Bo Jing in:Nature Research journals • PubMed • Google ScholarSearch for Qi Zhang in:Nature Research journals • PubMed • Google

Antigen distribution of TMUV and GPV are coincident with the expression profiles of CD8α-positive cells and goose IFNγ

Jia, Dekang Zhu, Fei Liu, Qiao Yang, Ying Wu, Kunfeng Sun, Xiaoyue Chen, Bo Jing & Anchun Cheng AuthorsSearch for Hao Zhou in:Nature Research journals • PubMed • Google ScholarSearch for Shun Chen ... journals • PubMed • Google ScholarSearch for Xiaoyue Chen in:Nature Research journals • PubMed • Google ScholarSearch for Bo Jing in:Nature Research journals • PubMed • Google ScholarSearch for Anchun Cheng

Improved eavesdropping detection strategy based on four-particle cluster state in quantum direct communication protocol

In order to improve the eavesdropping detection efficiency in a two-step quantum direct communication protocol, an improved eavesdropping detection strategy using the four-particle cluster state is proposed, in which the four-particle cluster state is used to detect eavesdroppers. During the security analysis, the method of the entropy theory is introduced, and two detection...

Illumina Miseq platform analysis caecum bacterial communities of rex rabbits fed with different antibiotics

Antibiotics have been widely used for the prevention and the treatment of diseases to humans and animals, and they have fed additives for agricultural animals to promote growth. However, there is a growing concern over the practice due to its side effects on intestinal microbial communities which plays a vital role in animals’ health. To investigate the effect of antibiotics on...