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Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers

Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability. CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location- and step-specificity. In recent years, circRNAs are attracting considerable research attention attributed to their possible contributions to gene regulation through a variety of actions, including sponging...

Extraordinary pseudocapacitive energy storage triggered by phase transformation in hierarchical vanadium oxides

Pseudocapacitance holds great promise for improving energy densities of electrochemical supercapacitors, but state-of-the-art pseudocapacitive materials show capacitances far below their theoretical values and deliver much lower levels of electrical power than carbon-based materials due to poor cation accessibility and/or long-range electron transferability. Here we show that in...

Analytical Formulations in the Domain Decomposition Method using Cylindrical Control Surface

The seakeeping problem is very important for marine structures, but present boundary element methods have still unresolved difficulties. In this work, the Green function method (Green function satisfying the linear boundary condition at free surface) is combined with the Rankine panel method so that two methods keep their advantages and brings important benefits. The fluid domain...

KBNN Based on Coarse Mesh to Optimize the EBG Structures

, Jiangsu 212003, China 2Nanjing Software Institute, Jinling Institute of Technology, Nanjing, Jiangsu 211169, China Correspondence should be addressed to Yu-bo Tian; nc.ude.tsuj@obuynait Received 11 July

KBNN Based on Coarse Mesh to Optimize the EBG Structures

, Jiangsu 212003, China 2Nanjing Software Institute, Jinling Institute of Technology, Nanjing, Jiangsu 211169, China Correspondence should be addressed to Yu-bo Tian; nc.ude.tsuj@obuynait Received 11 July

Neuroglobin boosts axon regeneration during ischemic reperfusion via p38 binding and activation depending on oxygen signal

Cerebral ischemia causes severe cell death or injury including axon breakdown or retraction in the brain. Axon regeneration is crucial for the functional recovery of injured neurons or brains after ischemia/reperfusion (I/R); however, this process has been proved extremely difficult in adult brains and there is still no effective therapy for it. Here we reported that neuroglobin...

Quantitative proteomics in A30P*A53T α-synuclein transgenic mice reveals upregulation of Sel1l

.), and the China Postdoctoral Scientific Foundation (No. 2015M582226 to P.Z.) . Author Contributions Conceptualization: Jianguo Yan, Bo Tian. Data curation: Jianguo Yan, Pei Zhang, Qingzhi Wang, Xiang ... Peng, Bo Tian. Formal analysis: Pei Zhang, Feng He. Funding acquisition: Bo Tian. Investigation: Jianguo Yan, Fengjuan Jiao, Qian Zhang. Project administration: Qian Zhang. Software: Pei Zhang, Feng

Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells

Physician Scientist Award (D.G.V.), an unrestricted grant (J.W.M.) from the research to prevent blindness foundation; NEI grant EY014104 (Meei Core Grant). Author information Author notes Bo Tian and Ahmad ... & Visual Sciences, University of Massachusetts Medical School, Worcester, MA, 01605, United StatesHaijiang Lin AuthorsSearch for Bo Tian in:Nature Research journals • PubMed • Google Scholar Search for

Association of LRRK2 R1628P variant with Parkinson’s disease in Ethnic Han-Chinese and subgroup population

Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). The R1628P variant of LRRK2 may be a specific risk factor for PD in ethnic Han-Chinese populations. This study is to elucidate the epidemiological feature of R1628P in ethnic Han-Chinese population with PD. A comprehensive meta...

Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity

Background Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). Among the mutations, LRRK2 c.4883G>C (R1628P) variant was identified to have a significant association with the risk of PD in ethnic Han-Chinese populations. But the molecular pathological mechanisms of R1628P mutation in PD...

Metabolic Syndrome: An Important Risk Factor for Parkinson’s Disease

Academic Editor: Xiaoqian Chen Copyright © 2014 Pei Zhang and Bo Tian. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

Metabolic Syndrome: An Important Risk Factor for Parkinson’s Disease

Academic Editor: Xiaoqian Chen Copyright © 2014 Pei Zhang and Bo Tian. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use

The prognostic value of AGR2 expression in solid tumours: a systematic review and meta-analysis

The prognostic value of anterior gradient-2 (AGR2) in tumours remains inconclusive. Here, we systematically reviewed the literature evidence and assessed the association between AGR2 expression and prognosis in solid tumours. The primary outcomes were overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS)/recurrence-free survival (RFS)/progression...

Membrane Lipid Remodelling of Meconopsis racemosa after Its Introduction into Lowlands from an Alpine Environment

Membrane lipids, which determine the integrity and fluidity of membranes, are sensitive to environmental changes. The influence of stresses, such as cold and phosphorus deficiency, on lipid metabolism is well established. However, little is known about how plant lipid profiles change in response to environmental changes during introduction, especially when plants are transferred...

Land claim and loss of tidal flats in the Yangtze Estuary

Tidal flats play a critical role in supporting biodiversity and in providing ecosystem services but are rapidly disappearing because of human activities. The Yangtze Estuary is one of the world’s largest alluvial estuaries and is adjacent to the most developed economic zone in China. Using the Yangtze Estuary as a study region, we developed an automatic algorithm to estimate...

miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells

Oxidative stress has been shown to contribute to the development of age-related macular degeneration (AMD). MicroRNAs (miRNA) are small non-coding RNA molecules that function in RNA silencing and post-transcriptional regulation of gene expression. We showed miR-17-3p to be elevated in macular RPE cells from AMD patients and in ARPE-19 cells under oxidative stress. Transfection of...

Effect of Grape Polyphenols on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials

Background The effect of grape polyphenols on blood pressure remains unclear, which we aimed to address via a meta-analysis study. Methods We conducted study trial searches in PubMed, Embase, and the Cochrane Library databases. Summary estimates of weighted mean differences and 95% confidence intervals were obtained by using fixed-effects models. Subgroup analyses were performed...

Diagnosis and Treatment of Autoimmune Pancreatitis in China: A Systematic Review

Aims To provide comprehensive data on the diagnosis and treatment of autoimmune pancreatitis (AIP) patients in China. Design A systematic review. Methods All clinical studies concerning AIP from China published between January 2006 and June 2014 were retrospectively reviewed and analyzed. Results A total of 26 original articles involving 706 AIP patients were included with an...

Laser diagnostics of pulverized coal combustion in O2/N2 and O2/CO2 conditions: velocity and scalar field measurements

. Lowe 0 Bo Tian 0 Yi Gao 0 0 Department of Engineering, University of Cambridge , Trumpington Street, Cambridge , UK Optical diagnostic techniques are applied to a 21 kW laboratory-scale pulverized coal ... / K02924X/1), S. Lowe acknowledges support through an EPSRC DTA grant, M. Kamal is supported by University of Engineering and Technology Peshawar (Pakistan), and Bo Tian acknowledges support from CSC. Open

Significance of Serum Pepsinogens as a Biomarker for Gastric Cancer and Atrophic Gastritis Screening: A Systematic Review and Meta-Analysis

Background Human pepsinogens are considered promising serological biomarkers for the screening of atrophic gastritis (AG) and gastric cancer (GC). However, there has been controversy in the literature with respect to the validity of serum pepsinogen (SPG) for the detection of GC and AG. Consequently, we conducted a systematic review and meta-analysis to assess the diagnostic...