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A note on misspecification in general linear models with correlated errors for the analysis of crossover clinical trials

]. Senn Funding: Dr. Bo Zhang?s research was partially supported by the National Institutes of Health grant U24 AA026968 and the University of Massachusetts Center for Clinical and Translational Science ... recommendations beyond this range of design specifications require further investigation and evidence. Acknowledgments This research was initiated and partially completed during Dr. Bo Zhang?s tenure at the U.S

A High-Efficiency 220 GHz Doubler Based on the Planar Schottky Varactor Diode

In this paper, we present the design, analysis and measurement of a 220 GHz doubler, based on a planar Schottky varactor diode. The 3D model of the varactor diodes were firstly established in a high-frequency structure simulator, then the parasitic parameters were extracted and imported into advanced design system, in order to optimize the whole circuit. The experiment on the...

Effects of vitamin D3 and its chemical analogs on the growth of Hodgkin’s lymphoma, in vitro

ObjectiveVitamin D receptor (VDR) activities have been noted for a number of B cell malignancies which showed varying sensitivities to vitamin D3 (1,25-dihydroxyvitamin D3, VD3, calcitriol) and its synthetic analogs. The objective of this study was to address the potential effects of VD3 and vitamin D3 analogs (VDAs) on the growth of Hodgkin’s lymphoma (HL), a malignant pathology...

Performance bottleneck analysis and resource optimized distribution method for IoT cloud rendering computing system in cyber-enabled applications

This paper analyzes current cloud computing, cloud rendering industry, and related businesses. In this field, cloud system performance lacks unified evaluation criterion. A novel analysis method and a related measure of cloud rendering system performance are presented in this paper. The main paper investigates the number of system concurrent users and average response delay about...

TNF-α/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT

injury-induced neuropathic pain. Notes Huan-Huan Ding and Su-Bo Zhang contributed equally to this work. Abbreviations DRG:  Dorsal root ganglion L5-VRT:  Lumbar 5 ventral root transection mRNA

OsCDC48/48E complex is required for plant survival in rice (Oryza sativa L.)

Cell division cycle 48 (CDC48) belongs to the superfamily protein of ATPases associated with diverse cellular activities (AAA). We previously isolated a rice CDC48 mutant (psd128) displaying premature senescence and death phenotype. Here, we showed that OsCDC48 (Os03g0151800) interacted with OsCDC48E (Os10g0442600), a homologue of OsCDC48, to control plant survival in rice...

Ultra-Low Specific On-resistance Lateral Double-Diffused Metal-Oxide-Semiconductor Transistor with Enhanced Dual-Gate and Partial P-buried Layer

An ultra-low specific on-resistance (Ron,sp) lateral double-diffused metal-oxide-semiconductor transistor (LDMOS) with enhanced dual-gate and partial P-buried layer is proposed and investigated in this paper. On-resistance analytical model for the proposed LDMOS is built to provide an in-depth insight into the relationship between the drift region resistance and the channel...

Synchronous Gastrointestinal Tumor and Abdominal Aortic Aneurysm or Dissection Treated with Endovascular Aneurysm Repair Followed by Tumor Resection

Zhaofei Zeng Department of Radiology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China Correspondence should be addressed to Bo Zhang; moc.361@61609791obgnahz Received 12 ... June 2018; Accepted 20 December 2018; Published 6 January 2019 Academic Editor: Nicola Silvestris Copyright © 2019 Bo Zhang et al. This is an open access article distributed under the Creative Commons

A Nanoscale Low-Power Resistorless Voltage Reference with High PSRR

In this paper, a nano-watt resistorless subthreshold voltage reference with high-power supply rejection ratio (PSRR) is presented. A self-biased MOS voltage divider is proposed to provide bias current for whole voltage reference, which is a positive temperature coefficient (TC) current containing threshold voltage characteristics. By injecting the generated current into a...

Evaluation of spatial distribution and characterization of wall shear stress in carotid sinus based on two-dimensional color Doppler imaging

useful tool for early and accurate prediction of the site of atherosclerosis in clinical. Notes Bo Zhang and Yuqin Ma contributed equally to this paper Declarations Authors’ contributions Performed

Approximation formulas related to Somos’ quadratic recurrence constant

We present two classes of asymptotic expansions related to Somos’ quadratic recurrence constant and provide the recursive relations for determining the coefficients of each class of the asymptotic expansions by using Bell polynomials and other techniques. We also present continued fraction approximations related to Somos’ quadratic recurrence constant.

Improving characterisation of human Multipotent Stromal Cells cultured in 2D and 3D: Design and evaluation of primer sets for accurate gene expression normalisation

International (CRMI). Author Contributions Conceptualization: Bas Brinkhof, Zhanfeng Cui, Hua Ye, Hui Wang. Data curation: Bas Brinkhof, Huidong Jia. Formal analysis: Bas Brinkhof, Huidong Jia, Bo Zhang ... . Validation: Bas Brinkhof. Visualization: Bo Zhang. Writing ? original draft: Bas Brinkhof, Huidong Jia, Hui Wang. Writing ? review & editing: Bas Brinkhof, Huidong Jia, Zhanfeng Cui, Hua Ye, Hui Wang. 15

A High-Accuracy AlGaN/GaN Reverse Blocking CRD (RB-CRD) with Hybrid Trench Cathode

An AlGaN/GaN lateral reverse blocking current regulating diode (RB-CRD) with trench Schottky anode and hybrid trench cathode has been proposed and experimentally demonstrated on silicon substrate. The Schottky barrier diode (SBD) integrated in the anode exhibits a turn-on voltage of 0.7 V and a reverse breakdown voltage of 260 V. The hybrid trench cathode acts as a CRD, which is...

Equilibria between the K+ binding and cation vacancy conformations of potassium channels

 XuXiaoying CaiTing ZhouMu YuJun LiangXiao ZhengChanglin Tian Open Access Letter First Online: 25 February 2019 Yao He and Bo Zhang contributed equally to this work. Electronic supplementary material

Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys

BackgroundAcute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, with liver transplantation as the only treatment option. Treatment of mesenchymal stem cells has shown a potential therapeutic option for acute liver failure. However, the lack of random clinical trials and large non-human primate studies makes it necessary to assess the...

Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys

Acute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, with liver transplantation as the only treatment option. Treatment of mesenchymal stem cells has shown a potential therapeutic option for acute liver failure. However, the lack of random clinical trials and large non-human primate studies makes it necessary to assess the efficacy and...

Downregulation of RdDM during strawberry fruit ripening

Recently, DNA methylation was proposed to regulate fleshy fruit ripening. Fleshy fruits can be distinguished by their ripening process as climacteric fruits, such as tomatoes, or non-climacteric fruits, such as strawberries. Tomatoes undergo a global decrease in DNA methylation during ripening, due to increased expression of a DNA demethylase gene. The dynamics and biological...

Plastic Design Theory of Frozen Wall Thickness in an Ultradeep Soil Layer Considering Large Deformation Characteristics

; Revised 12 April 2018; Accepted 30 April 2018; Published 31 May 2018 Academic Editor: Francesco Marotti de Sciarra Copyright © 2018 Bo Zhang et al. This is an open access article distributed under the

A Community Related Influence Evaluation Model for Social Networks with a Dynamic Perspective

, Tongji University, Shanghai 201804, China 2College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai 200234, China Correspondence should be addressed to Bo Zhang