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19 papers found.
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Spatiotemporal clustering of cases of Kawasaki disease and associated coronary artery aneurysms in Canada

Detailed epidemiologic examination of the distribution of Kawasaki disease (KD) cases could help elucidate the etiology and pathogenesis of this puzzling condition. Location of residence at KD admission was obtained for patients diagnosed in Canada (excluding Quebec) between March 2004 and March 2015. We identified 4,839 patients, 164 of whom (3.4%) developed a coronary artery...

Environmental epidemiology of Kawasaki disease: Linking disease etiology, pathogenesis and global distribution

Conceptualization: Cedric Manlhiot, Rae S. M. Yeung, Brian W. McCrindle. Data curation: Cedric Manlhiot, Brigitte Mueller, Haris Majeed, Brian W. McCrindle. Formal analysis: Cedric Manlhiot, Brigitte Mueller, Haris ... Majeed, Brian W. McCrindle. Funding acquisition: Brian W. McCrindle. Investigation: Cedric Manlhiot, Brigitte Mueller, Sunita O'Shea, Haris Majeed, Bailey Bernknopf, Michael Labelle, Katherine V. Westcott

Association between Vitamin D and Circulating Lipids in Early Childhood

Vitamin D is associated with established cardiovascular risk factors such as low density lipoprotein (LDL) in adults. It is unknown whether these associations are present in early childhood. To determine whether serum 25-hydroxyvitamin D (25(OH)D) is associated with serum non-high density lipoprotein (non-HDL) cholesterol during early childhood we conducted a cross-sectional...

Genetic determinants of right-ventricular remodeling after tetralogy of Fallot repair

, Cedric Manlhiot, Caroline Kinnear, Brian W. McCrindle, Glen van Arsdell, Andrew N. Redington & Seema MitalDepartment of Pediatrics, Hamilton Health Sciences Centre, Hamilton, Ontario, CanadaTapas ... Brian W. McCrindle in:Nature Research journals • PubMed • Google ScholarSearch for Glen van Arsdell in:Nature Research journals • PubMed • Google ScholarSearch for Andrew N. Redington in:Nature Research

Elastolytic Matrix Metalloproteinases and Coronary Outcome in Children with Kawasaki Disease

for Brian W McCrindle in:Nature Research journals • PubMed • Google ScholarSearch for Rae S M Yeung in:Nature Research journals • PubMed • Google Scholar Corresponding author Correspondence to Rae S M

Acute Kawasaki Disease in Association with Burn Injury

While the etiology of Kawasaki disease (KD) is unknown, a role for infectious agents, including common skin organisms, has been proposed. We report 2 cases of KD associated with burn injury. Case 1: A 2 year old boy was admitted with a first and second degree scald injury to more than 9% of his body. Initial leukocyte count (WBC) was elevated. He was discharged to home the next...

Parental Perceptions and Educational Needs Concerning Kawasaki Disease

Purpose: To determine factors associated with parental knowledge and concerns regarding Kawasaki disease (KD) in order to address misperceptions and educational needs. Methods: Self-administered questionnaire given at a follow-up clinic visit 6 to 8 weeks after the acute illness. Results: Over a 13 month period, surveys were completed by caregivers of 96 consecutive patients...

A Randomized Crossover Trial of Combination Pharmacologic Therapy in Children with Familial Hyperlipidemia

, CanadaElizabeth Helden & William T Conner AuthorsSearch for Brian W McCrindle in:Nature Research journals • PubMed • Google ScholarSearch for Elizabeth Helden in:Nature Research journals • PubMed • Google ... to Brian W McCrindle. Glossary HMG hydroxymethylglutaryl NCEP National Cholesterol Education Program Rights and permissions To obtain permission to re-use content from this article visit

The Epidemiology of Kawasaki Disease in Ontario and Canada

Purpose: We sought to determine recent trends in the incidence and epidemiologic features of Kawasaki disease (KD) in Ontario and Canada. Methods: A survey for incident cases from 1998-2000 was performed for all hospitals and pediatric cardiologists in Ontario. In addition, national hospital discharge abstract data from the Canadian Institute for Health Information (CIHI) was...

Severe Myocarditis in Children with Kawasaki Disease

Background: Severe myocarditis leading to heart failure is a specific entity complicating the acute phase of Kawasaki disease (KD) in children. Clinical course and response to therapy appear to differ in those children with myocarditis requiring inotropic treatment. Objective: To characterize specific clinical, laboratory and imaging findings in patients with severe myocarditis...