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11 papers found.
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Functional outcome of patients with prolonged hypoglycemic encephalopathy

Background Little is known about the causes, clinical course and long-term outcome of comatose patients with prolonged hypoglycemic encephalopathy. Methods In a multicenter retrospective study conducted in patients hospitalized from July 1, 2004, to July 1, 2014, we investigated functional long-term prognosis and identified prognosis factors of patients admitted in an intensive...

Study of Blood and Brain Lithium Pharmacokinetics in the Rat According to Three Different Modalities of Poisoning

Lithium-induced neurotoxicity may be life threatening. Three patterns have been described, including acute, acute-on-chronic, and chronic poisoning, with unexplained discrepancies in the relationship between clinical features and plasma lithium concentrations. Our objective was to investigate differences in plasma, erythrocyte, cerebrospinal fluid, and brain lithium...

Functional outcome of prolonged refractory status epilepticus

Introduction To characterize etiology, clinical course and outcomes of patients in prolonged refractory status epilepticus (PRSE) and looking for prognostic factors. Methods Retrospective study conducted in patients hospitalized from January 1, 2001 to December 31, 2011 in 19 polyvalent intensive care units in French university and general hospitals. Patients were adults with a...

Delayed immunosuppressive treatment in life-threatening paraquat ingestion: A case report

Introduction Combined glucocorticoids and cyclophosphamide pulse therapy showed promising results in moderate-to-severe paraquat poisonings to reduce life-threatening respiratory complications. Its benefit has been observed when given early in the course of poisoning; however, whether its delayed administration remains beneficial is unknown. Case Report We describe a 23-year-old...

Recommandations pour la prescription, la réalisation et l’interprétation des examens de biologie médicale dans le cadre des intoxications graves

Mathieu 2 Bruno Mégarbane 11 Patrick Nisse 12 0 Laboratoire de Biochimie et toxicologie, CHR Metz-Thionville, Hôpital Bel-Air , Rue du Friscaty, 57100 Thionville , France 1 Laboratoire Biochimie

Detection of Adduct on Tyrosine 411 of Albumin in Humans Poisoned by Dichlorvos

Studies in mice and guinea pigs have shown that albumin is a new biomarker of organophosphorus toxicant (OP) and nerve agent exposure. Our goal was to determine whether OP-labeled albumin could be detected in the blood of humans exposed to OP. Blood from four OP-exposed patients was prepared for mass spectrometry analysis by digesting 0.010 ml of serum with pepsin and purifying...

Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

Methadone, the most widely delivered maintenance therapy for heroin addicts, may be responsible for life-threatening poisonings with respiratory depression. The toxicokinetics and the toxicokinetic/toxicodynamic (TK/TD) relationships of methadone enantiomers have been poorly investigated in acute poisonings. The aim of this study was to describe the relationships between...

Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

Methadone, the most widely delivered maintenance therapy for heroin addicts, may be responsible for life-threatening poisonings with respiratory depression. The toxicokinetics and the toxicokinetic/toxicodynamic (TK/TD) relationships of methadone enantiomers have been poorly investigated in acute poisonings. The aim of this study was to describe the relationships between...

Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles

Introduction Prognostic factors in intentional insulin self-poisoning and the significance of plasma insulin levels are unclear. We therefore conducted this study to investigate prognostic factors in insulin poisoning, in relation to the value of plasma insulin concentration. Methods We conducted a prospective study, and used logistic regression to explore prognostic factors and...

Elevation of cardiac troponin I during non-exertional heat-related illnesses in the context of a heatwave

Introduction The prognostic value of cardiac troponin I (cTnI) in patients having a heat-related illness during a heat wave has been poorly documented. Methods In a post hoc analysis, we evaluated 514 patients admitted to emergency departments during the August 2003 heat wave in Paris, having a core temperature >38.5°C and who had analysis of cTnI levels. cTnI was considered as...

Difficulties in assessing cytomegalovirus-associated gastric perforation in an HIV-infected patient

Background Active Cytomegalovirus (CMV) infection is a common complication in advanced symptomatic Human Immunodeficiency Virus (HIV) infection. CMV-induced intestinal perforations are hard to diagnose and may be observed throughout the gastrointestinal tract. Isolated stomach perforation is exceptional. Case presentation A 47-year-old man was admitted to our intensive care unit...