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Investigating the use of Paleolithic perforated batons: new evidence from Gough’s Cave (Somerset, UK)

Perforated batons, usually made from a segment of antler and formed of a sub-cylindrical shaft and at least one perforation, have been documented across Europe from sites throughout the Upper Paleolithic and Mesolithic. The function of perforated batons is still debated. We present here three Magdalenian perforated batons from the site of Gough’s Cave (Somerset, UK); these are...

Inefficacy of the association N-methyl glucamine and topical miltefosine in the treatment of experimental cutaneous leishmaniasis by Leishmania (Leishmania) amazonensis

Pentavalent antimonial (SbV) is the first treatment for cutaneous leishmaniasis (CL). Other drugs present similar side effects and higher cost. Oral miltefosine is effective to treat kala-azar. The aim of the present study was to compare the efficacy of glucamine (SbV) plus topical miltefosine with glucamine in the treatment of CL. Eighty isogenic C57BL/6 mice were inoculated...

Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom

Venoms from snakes of the Bothrops genus are proteolytic, coagulant, hemorrhagic and nephrotoxic, causing edema, necrosis, hemorrhage and intense pain at the bite site, besides systemic alterations. Many adjuvants have been added to the venom used in the sensitization of antiserum-producer animals to increase antigenic induction and reduce the envenomation pathological effects...

Nitrogen Exchanges: Testing the Hypothesis of a Country without Agricultural Production

Today, finding data on agricultural nitrogen balances is quite easy. Calculations of such balances are carried out by most of the European countries as an indicator of environmental pollution attributable to the agricultural sector. In France, average values of agricultural nitrogen balances show an excess of 1.5 to 2 million tons of nitrogen. This excess is enormous. What would...

Nitrogen Exchanges: Testing the Hypothesis of a Country without Agricultural Production

Today, finding data on agricultural nitrogen balances is quite easy. Calculations of such balances are carried out by most of the European countries as an indicator of environmental pollution attributable to the agricultural sector. In France, average values of agricultural nitrogen balances show an excess of 1.5 to 2 million tons of nitrogen. This excess is enormous. What would...

Molecular mobility and activity in an intravital imaging setting – implications for cancer progression and targeting

Molecular mobility, localisation and spatiotemporal activity are at the core of cell biological processes and deregulation of these dynamic events can underpin disease development and progression. Recent advances in intravital imaging techniques in mice are providing new avenues to study real-time molecular behaviour in intact tissues within a live organism and to gain exciting...

Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations

clinical trial. JAMA Oncol 2016; 2(9): 1162?69. Author Contributions Conceptualization: Rekha Pal, Ning Wei, Peter C. Lucas, Ashok Srinivasan, Katherine L. Pogue-Geile. Data curation: Rekha Pal, Ning Wei ... Pal, Ning Wei, Patrick G. Gavin, Katherine L. Pogue-Geile. Supervision: Rekha Pal, Ning Wei, Rim S. Kim, Peter C. Lucas, Ashok Srinivasan, Carmen J. Allegra, John C. Schmitz, Katherine L. Pogue-Geile

Municipal wastewater can result in a dramatic decline in freshwater fishes: a lesson from a developing country

Impacts of ineffective wastewater management on the biodiversity of receiving waters in developing countries are poorly documented. Using a before-after-control-impact methodology, we measured the effects of untreated wastewater release on the fish community in the Barnoi River, Bangladesh. In 2006, prior to untreated wastewater discharge, fish abundance, species richness and...

Paradoxical Exploitation of Protected Fishes As Bait for Anglers: Evaluating the Lamprey Bait Market in Europe and Developing Sustainable and Ethical Solutions

L. Foulds 0 Martyn C. Lucas 0 Z. Daniel Deng, Pacific Northwest National Laboratory, United States of America 0 School of Biological and Biomedical Sciences, Durham University , Durham, County Durham

Vinflunine–gemcitabine versus vinflunine–carboplatin as first-line chemotherapy in cisplatin-unfit patients with advanced urothelial carcinoma: results of an international randomized phase II trial (JASINT1)†

Background There is no standard first-line chemotherapy for advanced urothelial carcinoma (aUC) in cisplatin-ineligible (cisplatin-unfit) patients. The study assessed the efficacy and tolerability profile of two vinflunine-based cytotoxic regimens in this setting.

THE WITHIN-CATCHMENT INVASION OF THE NON-INDIGENOUS SIGNAL CRAYFISH PACIFASTACUS LENIUSCULUS (DANA),IN UPLAND RIVERS

The American signal crayfish, Pacifastacus leniusculus, is an invasive species from North America that has been widely introduced through Europe, where it is a major threat to native European crayfish species and causing increasing concern because of its impact on the wider aquatic ecosystem. Although widely considered invasive, little is known of the rates of invasion and...

THE WITHIN-CATCHMENT INVASION OF THE NON-INDIGENOUS SIGNAL CRAYFISH PACIFASTACUS LENIUSCULUS (DANA),IN UPLAND RIVERS

The American signal crayfish, Pacifastacus leniusculus, is an invasive species from North America that has been widely introduced through Europe, where it is a major threat to native European crayfish species and causing increasing concern because of its impact on the wider aquatic ecosystem. Although widely considered invasive, little is known of the rates of invasion and...

CONDITIONED TASTE AVERSION AND THE MYERS’ HIGH-ETHANOL-PREFERRING RAT

LOU ANNE C. LUCAS 0 BRIAN A. MCMILLEN 0 0 Center for Alcohol and Drug Abuse Studies & Department of Pharmacology, Brody School of Medicine, East Carolina University , Greenville, NC 27858, USA Aims

NF-κB signaling in lymphocytes: a new cast of characters

Peter C. Lucas Linda M. McAllister-Lucas 0 Gabriel Nunez 0 Pediatrics, University of Michigan Medical School , 4131 CCGC, 1500 East Medical Center Dr., Ann Arbor, MI 48109 , USA - Cell-surface

One year comparison between two add‐back therapies in patients treated with a GnRH agonist for symptomatic endometriosis: a randomized double‐blind trial

BACKGROUND: It has been proposed that hormonal supplementation during prolonged GnRH agonist therapy prevents hypoestrogenic side effects, including bone loss. The optimal combination for long‐term treatments with safe metabolic profile remains questionable. A norprogesterone derivative, promegestone, was assessed for the first time in a double‐blind trial. METHODS: Seventy‐eight...