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Search: authors:"Caoqi Lei"

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Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- and TLR4. Here we identify USP19 as a negative regulator of TLR3/4-mediated signaling. USP19 deficiency increases the production of type I interferons (IFN) and proinflammatory cytokines induced by poly(I:C) or LPS...

Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway

430072, ChinaCaoqi Lei, Zhisheng Xu, Shu Li & Hongbing Shu AuthorsSearch for Dan Li in:Nature Research journals • PubMed • Google ScholarSearch for Caoqi Lei in:Nature Research journals • PubMed • Google