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84 papers found.
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Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets

BackgroundSystemic sclerosis (SSc) is a rare autoimmune fibrosing disease with an incompletely understood genetic and non-genetic etiology. Defining its etiology is important to allow the development of effective predictive, preventative, and therapeutic strategies. We conducted this epigenomic study to investigate the contributions of DNA methylation to the etiology of SSc while...

Adipose tissue depot volume relationships with spinal trabecular bone mineral density in African Americans with diabetes

. Freedman. Data curation: Gary C. Chan, Carl D. Langefeld, Jianzhao Xu, S. Carrie Smith, J. Jeffrey Carr, Leon Lenchik, Barry I. Freedman. Formal analysis: Jasmin Divers, Gregory B. Russell, Lynne E ... . Freedman. Supervision: Jasmin Divers, Carl D. Langefeld, Lynne E. Wagenknecht. Writing ? original draft: Gary C. Chan, Barry I. Freedman. Writing ? review & editing: Gary C. Chan, Jasmin Divers, Gregory B

Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster

, David M. Herrington, Carl D. Langefeld, Floyd H. Chilton. Data curation: Elaheh Rahbar, Hannah C. Ainsworth, Timothy D. Howard, James E. Hixson. Formal analysis: Elaheh Rahbar, Hannah C. Ainsworth ... , Timothy D. Howard, Ingo Ruczinski, Carl D. Langefeld. Funding acquisition: James E. Hixson, David M. Herrington, Floyd H. Chilton. Investigation: Elaheh Rahbar, Hannah C. Ainsworth, Timothy D. Howard

Genetics of autoimmune diseases: insights from population genetics

ScholarSearch for Andrew M Shedlock in:Nature Research journals • PubMed • Google ScholarSearch for Carl D Langefeld in:Nature Research journals • PubMed • Google Scholar Competing interests The authors declare

Genes Associated with SLE Are Targets of Recent Positive Selection

The reasons for the ethnic disparities in the prevalence of systemic lupus erythematosus (SLE) and the relative high frequency of SLE risk alleles in the population are not fully understood. Population genetic factors such as natural selection alter allele frequencies over generations and may help explain the persistence of such common risk variants in the population and the...

The new era of APOL1-associated glomerulosclerosis

Barry I. Freedman 1 Carl D. Langefeld 0 0 Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest School of Medicine , Winston-Salem, NC, USA 1 Section on Nephrology

Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos

Carlos Jose Rodriguez Gregory A. Talavera Carl D. Langefeld Lynne E. Wagenknecht Jill M. Norris Kent D. Taylor George Papanicolaou Eimear Kenny Ruth J. F. Loos Yii-Der Ida Chen Cathy Laurie 2 Tamar Sofer


, Medical Center Donald W. Bowden Boulevard, Winston- Carl D. Langefeld Salem, NC, USA Barry I. Freedman Correspondence and offprint requests to: Barry I. Freedman; E-mail: Medical management of

Evaluation of Candidate Nephropathy Susceptibility Genes in a Genome-Wide Association Study of African American Diabetic Kidney Disease

Type 2 diabetes (T2D)-associated end-stage kidney disease (ESKD) is a complex disorder resulting from the combined influence of genetic and environmental factors. This study contains a comprehensive genetic analysis of putative nephropathy loci in 965 African American (AA) cases with T2D-ESKD and 1029 AA population-based controls extending prior findings. Analysis was based on 4...

Complement factor H gene associations with end-stage kidney disease in African Americans

Background Mutations in the complement factor H gene (CFH) region associate with renal-limited mesangial proliferative forms of glomerulonephritis including IgA nephropathy (IgAN), dense deposit disease (DDD) and C3 glomerulonephritis (C3GN). Lack of kidney biopsies could lead to under diagnosis of CFH-associated end-stage kidney disease (ESKD) in African Americans (AAs), with...

Analysis of common and coding variants with cardiovascular disease in the diabetes heart study

Background Type 2 diabetes mellitus (T2DM) is a major cardiovascular disease (CVD) risk factor. Identification of genetic risk factors for CVD is important to understand disease risk. Two recent genome-wide association study (GWAS) meta-analyses in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium detected CVD-associated loci. Methods Variants...

Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study

Background Haptoglobin (HP) is an acute phase protein that binds to freely circulating hemoglobin. HP exists as two distinct forms, HP1 and HP2. The longer HP2 form has been associated with cardiovascular (CVD) events and mortality in individuals with type 2 diabetes (T2DM). Methods This study examined the association of HP genotypes with subclinical CVD, T2DM risk, and...

Gene–gene interactions in APOL1-associated nephropathy

Background Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk individuals develop ESKD, modifying factors likely contribute. Forty-two potentially interactive single nucleotide polymorphisms (SNPs) from a genome-wide association study in non-diabetic ESKD were...

Impact of HDL genetic risk scores on coronary artery calcified plaque and mortality in individuals with type 2 diabetes from the Diabetes Heart Study

Background Patients with type 2 diabetes (T2D) are at elevated risk for cardiovascular disease (CVD) events and mortality. Recent studies have assessed the impact of genetic variants affecting high-density lipoprotein cholesterol (HDL) concentrations on CVD risk in the general population. This study examined the utility of HDL-associated single nucleotide polymorphisms (SNPs) for...

A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)

Obesity is growing epidemic affecting 35% of adults in the United States. Previous genome-wide association studies (GWAS) have identified numerous loci associated with obesity. However, the majority of studies have been completed in Caucasians focusing on total body measures of adiposity. Here we report the results from genome-wide and exome chip association studies focusing on...

Association of polymorphisms in the klotho gene with severity of non-diabetic ESRD in African Americans

Background. Non-diabetic forms of nephropathy commonly lead to end-stage renal disease (non-DM ESRD). Previous studies have demonstrated that African Americans are more susceptible to non-DM ESRD compared to other ethnic groups, and this risk has a strong genetic component. A genome-wide scan for ESRD in African American families enriched for non-DM ESRD showed evidence for...

Genetic Risk Assessment of Type 2 Diabetes–Associated Polymorphisms in African Americans


Comparative analysis of methods for detecting interacting loci

Background Interactions among genetic loci are believed to play an important role in disease risk. While many methods have been proposed for detecting such interactions, their relative performance remains largely unclear, mainly because different data sources, detection performance criteria, and experimental protocols were used in the papers introducing these methods and in...