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Ethnic differences in metabolite signatures and type 2 diabetes: a nested case–control analysis among people of South Asian, African and European origin

Accumulation of metabolites may mark or contribute to the development of type 2 diabetes mellitus (T2D), but there is a lack of data from ethnic groups at high risk. We examined sphingolipids, acylcarnitines and amino acids, and their association with T2D in a nested case–control study among 54 South Asian Surinamese, 54 African Surinamese and 44 Dutch in the Netherlands. Plasma...

Inter-tissue coexpression network analysis reveals DPP4 as an important gene in heart to blood communication

BackgroundInter-tissue molecular interactions are critical to the function and behavior of biological systems in multicellular organisms, but systematic studies of interactions between tissues are lacking. Also, existing studies of inter-tissue interactions are based on direct gene expression correlations, which can’t distinguish correlations due to common genetic architectures...

Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance

Background The nuclear orphan receptor Nur77 (NR4A1, TR3, or NGFI-B) has been shown to modulate the inflammatory response of macrophages. To further elucidate the role of Nur77 in macrophage physiology, we compared the transcriptome of bone marrow-derived macrophages (BMM) from wild-type (WT) and Nur77-knockout (KO) mice. Results In line with previous observations, SDF-1α (CXCL12...

Integrative Analysis of DNA Methylation and Gene Expression Data Identifies EPAS1 as a Key Regulator of COPD

Chronic Obstructive Pulmonary Disease (COPD) is a complex disease. Genetic, epigenetic, and environmental factors are known to contribute to COPD risk and disease progression. Therefore we developed a systematic approach to identify key regulators of COPD that integrates genome-wide DNA methylation, gene expression, and phenotype data in lung tissue from COPD and control samples...

Lysosomal Stress in Obese Adipose Tissue Macrophages Contributes to MITF-Dependent Gpnmb Induction

In obesity, adipose tissue (AT) contains crown-like structures where macrophages surround nonviable adipocytes. To understand how AT macrophages (ATMs) contribute to development of insulin resistance, we examined their character in more detail. In silico analysis of F2 mouse populations revealed significant correlation between adipose glycoprotein nonmetastatic melanoma protein B...

The metabolic footprint of aging in mice

Research journals • PubMed • Google ScholarSearch for Carmen Argmann in:Nature Research journals • PubMed • Google ScholarSearch for Sander M. Houten in:Nature Research journals • PubMed • Google

Pparγ2 Is a Key Driver of Longevity in the Mouse

Aging involves a progressive physiological remodeling that is controlled by both genetic and environmental factors. Many of these factors impact also on white adipose tissue (WAT), which has been shown to be a determinant of lifespan. Interrogating a transcriptional network for predicted causal regulatory interactions in a collection of mouse WAT from F2 crosses with a seed set...

Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Long Bin Zhang Carmen Argmann Yong Zhao Charles V. Mobbs Eric E. Schadt Jun Zhu Zhidong Tu The GTEx Consortium RepoRts The original version of this Article contained a typographical error in the

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

, Icahn School of Medicine at Mount Sinai, NY, 10029, USAJialiang Yang, Tao Huang, Francesca Petralia, Quan Long, Bin Zhang, Carmen Argmann, Yong Zhao, Eric E. Schadt, Jun Zhu, Zhidong Tu & Luan ... LinDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY, 10029, USAJialiang Yang, Tao Huang, Francesca Petralia, Quan Long, Bin Zhang, Carmen Argmann, Yong Zhao, Eric E. Schadt