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6 papers found.
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Hsp90 Blockers Inhibit Adipocyte Differentiation and Fat Mass Accumulation

Geldanamycin derivatives are benzoquinone ansamycin antibiotics that bind to Hsp90 and alter its function. The alteration of Hsp90 activity limits some cellular hormonal responses by inhibiting nuclear receptors activation. The nuclear receptors activity, such as PPARγ, the mineralocorticoid and glucocorticoid receptors (MR and GR) play a critical role in the conversion of...

Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay

2011; Accepted 15 September 2011 Academic Editor: Rodolfo Rey Copyright © 2012 Caterina Mammi et al. This is an open access article distributed under the Creative Commons Attribution License, which

Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay

2011; Accepted 15 September 2011 Academic Editor: Rodolfo Rey Copyright © 2012 Caterina Mammi et al. This is an open access article distributed under the Creative Commons Attribution License

Androgens and Adipose Tissue in Males: A Complex and Reciprocal Interplay

2011; Accepted 15 September 2011 Academic Editor: Rodolfo Rey Copyright © 2012 Caterina Mammi et al. This is an open access article distributed under the Creative Commons Attribution License, which

Sildenafil Reduces Insulin-Resistance in Human Endothelial Cells

Background The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function is reduced in diabetic patients. Recent evidences suggest that therapy with PDE5 inhibitors, i.e. sildenafil, may increase the expression of nitric oxide synthase (NOS) proteins in the heart and cardiomyocytes. In this study we analyzed the effect of sildenafil on endothelial...