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12 papers found.
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Hippocampus-sparing radiotherapy using volumetric modulated arc therapy (VMAT) to the primary brain tumor: the result of dosimetric study and neurocognitive function assessment

We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated with radiotherapy. We reviewed data from patients with primary brain tumors who underwent hippocampal-sparing brain radiotherapy via VMAT between February 2014 and December 2015. The...

A practical scoring system to determine whether to proceed with surgical resection in recurrent glioblastoma

Background To determine the benefit of surgical management in recurrent glioblastoma, we analyzed a series of patients with recurrent glioblastoma who had undergone surgery, and we devised a new scale to predict their survival.

Cerebrospinal fluid M staging for medulloblastoma: Reappraisal of Chang's M staging based on the CSF flow

Tumor seeding is a strong negative prognostic factor for patients with medulloblastoma. Because Chang's M staging is based primarily on CT and myelographic findings and might be contradictory to the direction of normal cerebrospinal fluid (CSF) flow, seeding patterns and appropriate staging of medulloblastoma need to be revisited in patients diagnosed in the MRI era. We...

Recursive partitioning analysis of prognostic factors in WHO grade III glioma patients treated with radiotherapy or radiotherapy plus chemotherapy

Background We evaluated the hierarchical risk groups for the estimated survival of WHO grade III glioma patients using recursive partitioning analysis (RPA). To our knowledge, this is the first study to address the results of RPA specifically for WHO grade III gliomas. Methods A total of 133 patients with anaplastic astrocytoma (AA, n = 56), anaplastic oligodendroglioma (AO, n...

Usefulness of MS-MLPA for detection of MGMT promoter methylation in the evaluation of pseudoprogression in glioblastoma patients

Pseudoprogression is a major diagnostic dilemma in current treatment protocols for malignant gliomas that involve concurrent chemoradiotherapy. We hypothesized that methylation-specific multiplex ligation probe amplification (MS-MLPA), an assay that permits semiquantitative evaluation of promoter methylation, may be used to diagnose pseudoprogression based on the quantification...

Surgical Therapies

0 ST-01. MORBIDITY PROFILE ASSOCIATED WITH RESECTION OF CINGULATE GYRUS TUMORS Chae-Yong Kim 1 SC-37. NOVEL POPULATION OF NEURAL STEM CELLS IN THE VENTRAL PONS DURING CHILDHOOD AS A CANDIDATE CELL OF

NEUROSURGICAL TREATMENTS

Patients with cancer are at high risk of developing venous thromboembolism (VTE). The purpose of this study was to review VTE development in patients undergoing craniotomy for a neoplasm, and to further analyze risk based on multiple pre-, intra-, and post-operative variables. We analyzed all consecutive patients at our institution during the years 1999-2010 who were admitted for...

HIGH GRADE GLIOMAS AND DIPG

-Yong Kim, In-Ah Kim, Jung Ho Han, Byung-Se Choi, Hyo Seop Ahn, and Hyoung Soo Choi; Seoul National University Bundang Hospital, Seongnam, Republic of Korea BACKGROUND: Diffuse intrinsic pontine glioma ... strategies for the treatment of pediatric GBM. HG-020. CLINICAL AND RADIOLOGIC RESPONSE FOLLOWING BEVACIZUMAB AND IRINOTECAN IN RECURRENT OR PROGRESSIVE DIFFUSE PONTINE GLIOMA IN CHILDREN Sung Jin Kim, Chae

SURGICAL THERAPIES

INTRODUCTION: The role of aggressive surgical resection for glioblastoma multiforme (GBM) is controversial, with conflicting evidence published on the effect of extent of resection on outcome. We analyzed our patient population to determine if there was a correlation between greater extent of resection and overall survival or progression-free survival (PFS) in our neurosurgical...

CLIN-NEURO/MEDICAL ONCOLOGY

PURPOSE: This study was performed to evaluate the incidence of seizures with its implications on disease progression and the diagnostic value of post-ictal magnetic resonance images (MRI) during the management of high-grade gliomas (HGGs). PATIENTS AND METHODS: A total of 406 consecutive patients with newly diagnosed HGGs were retrospectively reviewed. The incidence of seizure...

Medical and Neuro-Oncology

INTRODUCTION: Patients with glioblastoma multiforme (GBM) are often prescribed antiepileptic drugs (AEDs) to treat or prevent seizures. Hepatic enzyme-inducing AEDs (EIAEDs) may enhance metabolism of antineoplastic chemotherapy, potentially abrogating therapeutic effects. However, a recent report paradoxically demonstrated improved survival of GBM patients treated with EIAEDs. We...