Advanced search    

Search: authors:"Chang Liu"

12 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex

Polycomb repression complex 2 (PRC2) component EZH2 tri-methylates H3K27 and exerts epigenetic repression on target gene expression. EZH2-mediated epigenetic control of RNA polymerase II (Pol II) transcribed coding gene transcription has been well established. However, little is known about EZH2-mediated epigenetic regulation of RNA polymerase III (Pol III) transcription. Here we...

Effect of homocysteine on intestinal permeability in rats with experimental colitis, and its mechanism

Objective: To investigate the effect of homocysteine (Hcy) on intestinal permeability in rats with TNBS/ethanol-induced colitis and elucidate its mechanism. Methods: Sprague-Dawley rats were divided into four groups: normal, normal + Hcy injection, TNBS model, and TNBS model + Hcy injection. Experimental colitis was induced by trinitrobenzene sulfonic acid (TNBS) in 50% ethanol...

PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression

Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator that catalyzes the trimethylation of H3K27 and is modulated by post-translational modifications (PTMs). However, the precise regulation of EZH2 PTMs remains elusive. We, herein, report that EZH2 is acetylated by acetyltransferase P300/CBP-associated factor (PCAF) and is deacetylated by deacetylase SIRT1. We...

ATHLATES: accurate typing of human leukocyte antigen through exome sequencing

Human leukocyte antigen (HLA) typing at the allelic level can in theory be achieved using whole exome sequencing (exome-seq) data with no added cost but has been hindered by its computational challenge. We developed ATHLATES, a program that applies assembly, allele identification and allelic pair inference to short read sequences, and applied it to data from Illumina platforms...

LlSR28 Is Involved in Pollen Germination by Affecting Filamentous Actin Dynamics

Alternative splicing plays important roles in gene regulation and contributes to protein complexity. Previous studies suggest that alternative splicing exists in members of the villin/gelsolin/fragmin superfamily. In this study, a serine/argine-rich (SR) protein cDNA with 28kDa protein (LlSR28) was isolated from a lily (Lilium longiflorum) expression library. Protein domain...

AtPUB19, a U-Box E3 Ubiquitin Ligase, Negatively Regulates Abscisic Acid and Drought Responses in Arabidopsis thaliana

Ubiquitination is an important protein post-translational modification, which is involved in various cellular processes in higher plants, and U-box E3 ligases play important roles in diverse functions in eukaryotes. Here, we describe the functions of Arabidopsis thaliana PUB19 (AtPUB19), which we demonstrated in an in vitro assay to encode a U-box type E3 ubiquitin ligase...

DNA linking number change induced by sequence-specific DNA-binding proteins

Sequence-specific DNA-binding proteins play a key role in many fundamental biological processes, such as transcription, DNA replication and recombination. Very often, these DNA-binding proteins introduce structural changes to the target DNA-binding sites including DNA bending, twisting or untwisting and wrapping, which in many cases induce a linking number change (ΔLk) to the DNA...

Detecting and understanding genetic and structural features in HIV-1 B subtype V3 underlying HIV-1 co-receptor usage

Motivation: To define V3 genetic elements and structural features underlying different HIV-1 co-receptor usage in vivo. Results: By probabilistically modeling mutations in the viruses isolated from HIV-1 B subtype patients, we present a unique statistical procedure that would first identify V3 determinants associated with the usage of different co-receptors cooperatively or...

Connexin 43 is involved in the generation of human-induced pluripotent stem cells

Qiong Ke Li Li Bing Cai Chang Liu Yan Yang Yong Gao Weijun Huang Xiaofeng Yuan Tao Wang Qi Zhang Andrew L. Harris Liang Tao Andy Peng Xiang Although somatic cells can be successfully programmed to

Delay of Gap Filling during Nucleotide Excision Repair by Base Excision Repair: The Concept of Competition Exemplified by the Effect of Propolis

Nucleotide excision repair (NER) consists of a sequence of events including DNA damage recognition, excision of the damage containing oligonucleotide, gap filling, and ligation. We found that gap filling during the repair of ultraviolet (UV)C-induced DNA lesions was inhibited by various compounds, e.g., amoxicillin, and mixtures, e.g., propolis, the materials that could induce...

Regulation of thymus PCNA expression is altered in radiation-sensitive wasted mice

arrest or apoptosis. Previous results from our laboratory indicate poor to undetectable expression of p53 in thymus and spleen of wasted mice compared with controls (Woloschak, Paunesku, and Chang-Liu, in

Regulation of thymus PCNA expression is altered in radiation-sensitive wasted mice

poor to undetectable expression of p53 in thymus and spleen of wasted mice compared with controls (Woloschak, Paunesku, and Chang-Liu, in preparation). The fact that neither p53 nor PCNA is expressed in ... - 1734 . 17. Woloschak , G.E. , Chang-Liu ,C. -M, ChungJ . and Libertin . C.R. ( 1996 ) Lymphocytes from wasted mice express enhanced spontaneous and y-ray induced apoptosis . Int. J. Radiat. Biol ., 69