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19 papers found.
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Impact of Transient and Persistent Acute Kidney Injury on Chronic Kidney Disease Progression and Mortality after Gastric Surgery for Gastric Cancer

Acute kidney injury (AKI) is common after gastric surgery for gastric cancer and associated with adverse outcomes. However, the impact of transient or persistent AKI on clinical outcomes after gastric surgery for gastric cancer has not been described. We performed a retrospective study of 4,886 patients with normal renal function who underwent partial or total gastrectomy for...

Nicotine-Induced Apoptosis in Human Renal Proximal Tubular Epithelial Cells

Background Nicotine is, to a large extent, responsible for smoking-mediated renal dysfunction. This study investigated nicotine’s effects on renal tubular epithelial cell apoptosis in vitro and it explored the mechanisms underlying its effects. Methods Human proximal tubular epithelial (HK-2) cells were treated with nicotine. Cell viability was examined by using the WST-1 assay...

Angiotensin-(1-7) Attenuates Kidney Injury Due to Obstructive Nephropathy in Rats

Background Angiotensin-(1–7) [Ang-(1–7)] counteracts many actions of the renin-angiotensin-aldosterone system. Despite its renoprotective effects, extensive controversy exists regarding the role of Ang-(1–7) in obstructive nephropathy, which is characterized by renal tubulointerstitial fibrosis and apoptosis. Methods To examine the effects of Ang-(1–7) in unilateral ureteral...

Association of Serum Osteoprotegerin Levels with Bone Loss in Chronic Kidney Disease: Insights from the KNOW-CKD Study

Medical Center, Eulji University. Suah Sung, MD, Sung Woo Lee, MD, and Min A Yoo, RN. Chonnam National University Hospital, Soo Wan Kim, MD, Seong Kwon Ma, MD, Eun Hui Bae, MD, Chang Seong Kim, MD, Yong Un

Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening

Background This study was aimed to examine the prevalence of metabolic syndrome (MS) and chronic kidney disease (CKD), and the association between MS and its components with CKD in Korea. Methods We excluded diabetes to appreciate the real impact of MS and performed a cross-sectional study using the general health screening data of 10,253,085 (48.86±13.83 years, men 56.18...

Farnesoid X Receptor Ligand Prevents Cisplatin-Induced Kidney Injury by Enhancing Small Heterodimer Partner

The farnesoid X receptor (FXR) is mainly expressed in liver, intestine and kidney. We investigated whether 6-ethyl chenodeoxycholic acid (6ECDCA), a semisynthetic derivative of chenodeoxycholic aicd (CDCA, an FXR ligand), protects against kidney injury and modulates small heterodimer partner (SHP) in cisplatin-induced kidney injury. Cisplatin inhibited SHP protein expression in...

Incidence, Predictive Factors, and Clinical Outcomes of Acute Kidney Injury after Gastric Surgery for Gastric Cancer

Background Postoperative acute kidney injury (AKI), a serious surgical complication, is common after cardiac surgery; however, reports on AKI after noncardiac surgery are limited. We sought to determine the incidence and predictive factors of AKI after gastric surgery for gastric cancer and its effects on the clinical outcomes. Methods We conducted a retrospective study of 4718...

Clinical Impact of Hospital-Acquired Anemia in Association with Acute Kidney Injury and Chronic Kidney Disease in Patients with Acute Myocardial Infarction

BackgroundHospital-acquired anemia (HAA) is common in patients with acute myocardial infarction (AMI) and is an independent indicator of long-term mortality in these patients. However, limited information exists regarding the development and prognostic impact of HAA associated with acute kidney injury (AKI) and chronic kidney disease (CKD) in AMI patients. Methods and ResultsWe...

Paricalcitol Attenuates 4-Hydroxy-2-Hexenal-Induced Inflammation and Epithelial-Mesenchymal Transition in Human Renal Proximal Tubular Epithelial Cells

4-Hydroxy-2-hexenal (HHE), the aldehyde product of lipid peroxidation, may be responsible for the pathogenesis of progressive renal disease. Recently, paricalcitol (19-nor-1,25-dihydroxyvitamin D2) was shown to be renoprotective through its anti-inflammatory and antifibrotic effects in various experimental nephropathy models. In this study, we investigated the effects of...

Concomitant renal insufficiency and diabetes mellitus as prognostic factors for acute myocardial infarction

Background Diabetes mellitus and renal dysfunction are prognostic factors after acute myocardial infarction (AMI). However, few studies have assessed the effects of renal insufficiency in association with diabetes in the context of AMI. Here, we investigated the clinical outcomes according to the concomitance of renal dysfunction and diabetes mellitus in patients with AMI...

Predicting outcomes after myocardial infarction by using the Chronic Kidney Disease Epidemiology Collaboration equation in comparison with the Modification of Diet in Renal Disease study equation: results from the Korea Acute Myocardial Infarction Registry

Background The presence of chronic kidney disease is an independent prognostic factor in patients with myocardial infarction (MI). We compared the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation and the Modification of Diet in Renal Disease (MDRD) study equation with regard to prognostic value in patients with MI.

CELL SIGNALLING AND APOPTOSIS

Introduction and Aims: Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, has been suggested to be involved in the mechanism of renal fibrosis. Previously, we have shown the direct effects of S1P on the fibrotic process in the unilateral ureteral obstruction (UUO) model using nude mice which were characterized by deficit of immune response. To get more insight into roles...

Clinical Nephrology - Epidemiology I

Introduction and Aims: Aldosterone-to-renin ratio (ARR) is believed to be a more robust screening test than aldosterone levels for primary aldosteronism, and it could be an index for inappropriate aldosterone activity and salt sensitivity. Recently, in a community-based longitudinal study in United States, aldosterone was associated with incident CKD and microalbuminuria...

HYPERTENSION

Introduction and Aims: Both increased albuminuria and reduced kidney function predict blood pressure (BP) progression in the community, and exacerbate each other’s effects. We investigated associations and interactions between these two risk factors, BP changes and hypertension incidence in community-dwelling elderly men. Methods: Cross-sectional and longitudinal observational...

Cell signalling

Introduction and Aims: Klotho is a protein that has anti-aging properties and is known to function as an obligate co-receptor of FGF23 in the regulation of phosphate homeostasis and also to be involved in insulin/IGF1 and WNT signaling, suggesting that Klotho has several biological properties in physiological and pathophysiological conditions. It has been reported that the renal...

CKD GENERAL AND CLINICAL EPIDEMIOLOGY 1

Introduction and Aims: In hemodialysis (HD) patients low pre-HD serum sodium (SNa+) and high Na+ gradients have been associated with higher mortality. Increased pre-HD SNa+ variability has been linked to mortality, while stable SNa+ levels are associated with better survival. Here we investigated the joint relationship of SNa+ variability (expressed as standard deviation, SD) and...

Lab methods / biomarkers

Introduction and Aims:Patients with Chronic Kidney Disease (CKD) and/or Diabetes are at a high risk for cardiovascular (CV) disease. Improved outcomes require a better understanding of specific risk factors that distinctly modulate the incidence of atheromatous disease. Herein. we compared the distinct and combined impact of CKD and of diabetes (DM) on the development of...

Cardiovascular complications in CKD 5D

Introduction and Aims: The aim of this study was to evaluate the association between the attainment of KDIGO suggestions for mineral and bone disorder (MBD) markers and the presence of various ankle brachial systolic pressure index (ABI) levels in our hemodialysis (HD) patients. Methods: In a cross-sectional study we analyzed 137 patients (85 male; mean age 55.8±14.2 years...

AKI - experimental models

Introduction and Aims:Clinical studies have demonstrated the risk of chronic kidney disease after the occurrence of an acute kidney injury (AKI). Experimental works indicate that AKI result in incomplete repair, persistent tubulointerstitial inflammation and fibrosis. Cysteine-rich protein 61 (Cyr61), a secreted matrix-associated protein, has been found to be up-regulated in the...