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23 papers found.
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Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition

Technology and Innovation Commission (Nos 201803010088, 201804010118). Author contributions Yongxu Chen and Wei Tan contributed to searching literature, drafting, and editing of the manuscript. Changjun Wang

Does rituximab improve clinical outcomes of patients with thyroid-associated ophthalmopathy? A systematic review and meta-analysis

Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement [9]. To assess the evidence on this issue, a broad literature search was independently initiated by Changjun Wang and Qingyao Ning ... reports, we applied for it directly from authors. These literatures were managed and duplicates were removed through Endnote X7 software (Changjun Wang and Qingyao Ning). Study selection The criteria

Breast cancer detected only by positron emission tomography with extensive osteolytic bone metastases mimicked Multiple Myeloma: A case report

, Feng Mao, Changjun Wang 1 Peking Union Medical College Hospital , Beijing , China been reported to have high sensitivity and specificity in its diagnosis. Clinical picture, radiological findings and

Virome analysis for identification of novel mammalian viruses in bats from Southeast China

He Jin Zhu Hui Qian Wenrong Xu Youjun Feng Weilong Tan Changjun Wang OPEN Bats have been shown as important mammal resevoirs to carry a variety of zoonotic pathogens. To analyze pathogenic species in

Differences in Factors Affecting Various Crash Types with High Numbers of Fatalities and Injuries in China

Objectives Road traffic crashes that involve very high numbers of fatalities and injuries arouse public concern wherever they occur. In China, there are two categories of such crashes: a crash that results in 10–30 fatalities, 50–100 serious injuries or a total cost of 50–100 million RMB ($US8-16m) is a “serious road traffic crash” (SRTC), while a crash that is even more severe...

Diagnostic Accuracy of PIK3CA Mutation Detection by Circulating Free DNA in Breast Cancer: A Meta-Analysis of Diagnostic Test Accuracy

Mutation of p110 alpha-catalytic subunit of phosphatidylinositol 3-kinase (PIK3CA) has high predictive and prognostic values for breast cancer. Hence, there has been a marked interest in detecting and monitoring PIK3CA genotype with non-invasive technique, such as circulating free DNA (cfDNA). However, the diagnostic accuracy of PIK3CA genotyping by cfDNA is still a problem of...

Molecularly Targeted Therapy of Human Hepatocellular Carcinoma Xenografts with Radio-iodinated Anti-VEGFR2 Murine-Human Chimeric Fab

Research journals • PubMed • Google ScholarSearch for Qi Tang in:Nature Research journals • PubMed • Google ScholarSearch for Changjun Wang in:Nature Research journals • PubMed • Google ScholarSearch for

Determination of Scrub typhus Suggests a New Epidemic Focus in the Anhui Province of China

Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Changjun Wang in:Nature Research journals • PubMed • Google ScholarSearch for Youjun Feng in:Nature Research journals • PubMed ... . analyzed the data. M.C., Y.F. and S.S. wrote this paper. Competing interests The authors declare no competing financial interests. Corresponding authors Correspondence to Changjun Wang or Youjun Feng

A Novel Chimeric Anti-PA Neutralizing Antibody for Postexposure Prophylaxis and Treatment of Anthrax

University, Nanjing 210029, ChinaSiping Xiong, Ya Chen & Zhenqing FengHuadong Medical Institute of Biotechniques, Nanjing 210002, ChinaTingting Zhou, Peng Liu, Changjun Wang & Jin ZhuKey Laboratory of Antibody ... • Google ScholarSearch for Changjun Wang in:Nature Research journals • PubMed • Google ScholarSearch for Zhenqing Feng in:Nature Research journals • PubMed • Google ScholarSearch for Jin Zhu in:Nature

A Human Anti-Toll Like Receptor 4 Fab Fragment Inhibits Lipopolysaccharide-Induced Pro-Inflammatory Cytokines Production in Macrophages

The results of clinical and experimental studies suggest that endotoxin/toll-like receptor 4 (TLR4)-mediated proinflammatory and profibrotic signaling activation is critical in the development of hepatic fibrosis. However, studies examining the role of specific TLR4 inhibitor are still lacking. The present study was aimed to prepare a human anti-TLR4 Fab fragment, named hTLR4...

Striking life events associated with primary breast cancer susceptibility in women: a meta-analysis study

Purpose The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relationship between striking life events and primary breast cancer incidence in women. Methods Systematic computerized searching of the PubMed, ScienceDirect, Embase, and...

Impact of Functional Constipation on Health-Related Quality of Life in Preschool Children and Their Families in Xi’an, China

AimFunctional constipation (FC) is one of the common diseases among children. The aim of this study was to investigate the health-related quality of life (HRQOL) in preschool children diagnosed with FC and the impact of the condition on affected families. MethodsIn this cross-sectional, case-control study, 152 children aged 3–6 years with FC, 176 healthy children aged 3–6 years...

A Human Anti-c-Met Fab Fragment Conjugated with Doxorubicin as Targeted Chemotherapy for Hepatocellular Carcinoma

c-Met is over-expressed in hepatocellular carcinoma(HCC) but is absent or expressed at low levels in normal tissues. Therefore we generated a novel conjugate of a human anti-c-Met Fab fragment (MetFab) with doxorubicin (DOX) and assessed whether it had targeted antitumor activity against HCC and reduced the side-effects of DOX. The MetFab was screened from human phage library...

Characterization of a Human Antibody Fragment Fab and Its Calcium Phosphate Nanoparticles that Inhibit Rabies Virus Infection with Vaccine

Recombinant antibody phage display technology has been used to mimic many aspects of the processes that govern the generation and selection of high-affinity natural human antibodies in the human immune system, especially for infectious disease prophylaxis. An anti-rabies virus immunized phage-display Fab library was constructed from peripheral blood lymphocytes from vaccinated...

Probing genomic diversity and evolution of Streptococcus suis serotype 2 by NimbleGen tiling arrays

Background Our previous studies revealed that a new disease form of streptococcal toxic shock syndrome (STSS) is associated with specific Streptococcus suis serotype 2 (SS2) strains. To achieve a better understanding of the pathogenicity and evolution of SS2 at the whole-genome level, comparative genomic analysis of 18 SS2 strains, selected on the basis of virulence and...


Spring scrub typhus has frequently occurred in Pingtan Island, China, since 2000. In this study, we amplified a 1352-bp DNA fragment encoding a truncated 56-kDa outer membrane protein of the Ptan strain, which was isolated from a serum sample of a patient with spring scrub typhus, and cloned it into the pET28a vector for expression. The expression product was a recombinant...

Streptococcus suis Enolase Functions as a Protective Antigen Displayed on the Bacterial Cell Surface

Background Streptococcus suis serotype 2 (SS2) has evolved into a highly infectious entity, posing a great threat to public health. Screening for and identification of protective antigens plays an important role in developing therapies against SS2 infections MethodsMultiple strategies were used to investigate a new surface protein that has the potential to be a protective antigen...

SalK/SalR, a Two-Component Signal Transduction System, Is Essential for Full Virulence of Highly Invasive Streptococcus suis Serotype 2

BackgroundStreptococcus suis serotype 2 (S. suis 2, SS2) has evolved into a highly infectious entity, which caused the two recent large-scale outbreaks of human SS2 epidemic in China, and is characterized by a toxic shock-like syndrome. However, the molecular pathogenesis of this new emerging pathogen is still poorly understood.Methodology/Principal Findings89K is a newly...