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miRNA-221 promotes cutaneous squamous cell carcinoma progression by targeting PTEN

BackgroundCutaneous squamous cell carcinoma (CSCC) is a common type of skin malignancy. MicroRNA-221 (miRNA-221) is a critical non-coding RNA in tumor initiation and progression. However, the molecular mechanisms of miRNA-221 in the development of CSCC remain unknown. This study investigated the expression of miRNA-221 in CSCC and its potential tumor biological functions...

Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations

The physiological asymmetry between daughters of a mother bacterium is produced by the inheritance of either old poles, carrying non-genetic damage, or newly synthesized poles. However, as bacteria display long-term growth stability leading to physiological immortality, there is controversy on whether asymmetry corresponds to aging. Here we show that deterministic age structure...

Geometric isotope effect of deuteration in a hydrogen-bonded host–guest crystal

Deuteration of a hydrogen bond by replacing protium (H) with deuterium (D) can cause geometric changes in the hydrogen bond, known as the geometric H/D isotope effect (GIE). Understanding the GIEs on global structures and bulk properties is of great importance to study structure–property relationships of hydrogen-bonded systems. Here, we report a hydrogen-bonded host–guest...

DNA Self-assembly Catalyzed by Artificial Agents

Nucleic acids have been shown to be versatile molecules and engineered to produce various nanostructures. However, the poor rate of these uncatalyzed nucleic acid reactions has restricted the development and applications. Herein, we reported a novel finding that DNA self-assembly could be nonenzymatically catalyzed by artificial agents with an increasing dissociation rate...

Initial meconium microbiome in Chinese neonates delivered naturally or by cesarean section

Author notes Yi-Chao Shi, He Guo and Jing Chen contributed equally to this work. AffiliationsDepartment of Gastroenterology and Hepatology, Institute of Digestive Diseases, Chinese PLA General Hospital ... , Beijing, ChinaYi-Chao Shi, He Guo, Gang Sun, Rong-Rong Ren, Ming-Zhou Guo, Li-Hua Peng & Yun-Sheng YangRealbio Genomics Institute, Shanghai, 200050, ChinaJing Chen AuthorsSearch for Yi-Chao Shi in:Nature

Photon-phonon Interaction in a Microfiber Induced by Optical and Electrostrictive Forces

Optical and Electrostrictive Forces Yun-chao Shi, Wei Luo, Fei Xu & Yan-qing Lu Experimental and theoretical results of spontaneous Brillouin scattering (SpBS) in solid silica microfibers have been

Pseudoscalar mesons parton distribution amplitudes

We compute all kaon and pion parton distribution amplitudes (PDAs) to twist-three and find that all of the pion’s distributions are symmetric and all of the kaon’s distributions are skewed in favour of the heavier s-quark, which are clear signals of dynamical chiral symmetry breaking (DCSB). And we can also notice that only the pseudotensor PDA can reasonably be approximated by...

Pseudoscalar mesons parton distribution amplitudes

We compute all kaon and pion parton distribution amplitudes (PDAs) to twist-three and find that all of the pion’s distributions are symmetric and all of the kaon’s distributions are skewed in favour of the heavier s-quark, which are clear signals of dynamical chiral symmetry breaking (DCSB). And we can also notice that only the pseudotensor PDA can reasonably be approximated by...

Outbreaks of acute gastroenteritis associated with a re-emerging GII.P16-GII.2 norovirus in the spring of 2017 in Jiangsu, China

Yi, Jun Zhang. Writing ± original draft: Chao Shi, Jing Ai. Writing ± review & editing: Jian-Guang Fu, Zheng Xing. 9 / 10 1. Patel MM , Widdowson MA , Glass RI , Akazawa K , Vinje J , Parashar UD

Full transcription of the chloroplast genome in photosynthetic eukaryotes

Prokaryotes possess a simple genome transcription system that is different from that of eukaryotes. In chloroplasts (plastids), it is believed that the prokaryotic gene transcription features govern genome transcription. However, the polycistronic operon transcription model cannot account for all the chloroplast genome (plastome) transcription products at whole-genome level...

Chronic Exposure to Tributyltin Induces Brain Functional Damage in Juvenile Common Carp (Cyprinus carpio)

The aim of the present study was to investigate the effect of Tributyltin (TBT) on brain function and neurotoxicity of freshwater teleost. The effects of long-term exposure to TBT on antioxidant related indices (MDA, malondialdehyde; SOD, superoxide dismutase; CAT, catalase; GR, glutathione reductase; GPx, glutathione peroxidase), Na+-K+-ATPase and neurological parameters (AChE...

Antimicrobial Activity and Possible Mechanism of Action of Citral against Cronobacter sakazakii

Citral is a flavor component that is commonly used in food, beverage and fragrance industries. Cronobacter sakazakii is a food-borne pathogen associated with severe illness and high mortality in neonates and infants. The objective of the present study was to evaluate antimicrobial effect of citral against C. sakazakii strains. The minimum inhibitory concentration (MIC) of citral...

Elcatonin attenuates disuse osteoporosis after fracture fixation of tubular bone in rats

Background Elcatonin (ECT) is used to prevent and treat osteoporosis. However, little is known about its effect on the disuse osteoporosis (DOP). The aim of this study is to evaluate the effect of ECT on DOP caused by fracture fixation. Methods Forty-five male Sprague-Dawley (SD) rats, aged 6 weeks, were randomly allocated into three groups: the control group without surgery and...

Effect of caesarean section on maternal and foetal outcomes in acute fatty liver of pregnancy: a systematic review and meta-analysis

Several studies have reported a positive association between caesarean section for expeditious pregnancy termination and perinatal outcomes in acute fatty liver of pregnancy (AFLP); however, the risks remain unclear and independent studies have reported conflicting findings. In this meta-analysis, we aimed to confirm the relationship between caesarean section and perinatal...

Locate QCD critical end point in a continuum model study

With a modified chemical potential dependent effective model for the gluon propagator, we try to locate the critical end point (CEP) of strongly interacting matter in the framework of Dyson-Schwinger equations (DSE). Beyond the chiral limit, we find that Nambu solution and Wigner solution could coexist in some area. Using the CornwallJackiw-Tomboulis (CJT) effective action, we...

Numerical Simulation of Underwater Shock Wave Propagation in the Vicinity of Rigid Wall Based on Ghost Fluid Method

25 September 2014; Accepted 17 December 2014 Academic Editor: Chao Tao Copyright © 2015 Ru-Chao Shi et al. This is an open access article distributed under the Creative Commons Attribution License

Numerical Simulation of Underwater Shock Wave Propagation in the Vicinity of Rigid Wall Based on Ghost Fluid Method

25 September 2014; Accepted 17 December 2014 Academic Editor: Chao Tao Copyright © 2015 Ru-Chao Shi et al. This is an open access article distributed under the Creative Commons Attribution License

Plastid Genome Sequence of a Wild Woody Oil Species, Prinsepia utilis, Provides Insights into Evolutionary and Mutational Patterns of Rosaceae Chloroplast Genomes

BackgroundPrinsepia utilis Royle is a wild woody oil species of Rosaceae that yields edible oil which has been proved to possess particular benefits for human health and medical therapy. However, the lack of bred varieties has largely impeded exploiting immense potentials for high quality of its seed oil. It is urgently needed to enlarge the knowledge of genetic basis of the...

The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein

Background Since the identification of poly-alanine expanded poly(A) binding protein nuclear 1 (PABPN1) as the genetic cause of oculopharyngeal muscular dystrophy (OPMD), considerable progress has been made in our understanding of the pathogenesis of the disease. However, the molecular mechanisms that regulate the onset and progression of the disease remain unclear. Results In...

Mycobacterium leprae-Infected Macrophages Preferentially Primed Regulatory T Cell Responses and Was Associated with Lepromatous Leprosy

Background The persistence of Mycobacterium leprae (M. leprae) infection is largely dependent on the types of host immune responses being induced. Macrophage, a crucial modulator of innate and adaptive immune responses, could be directly infected by M. leprae. We therefore postulated that M. leprae-infected macrophages might have altered immune functions. Methodology/Principal...