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79 papers found.
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A new technique for nanoparticle transport and its application in a novel nano-sieve

A new technique is proposed to transport and further classify nanoparticles of different sizes. A graphene sheet is used as the substrate; a nanoparticle is placed on the substrate and a sliding block is located below the substrate. As the sliding block moves under the graphene substrate, a driving force is yielded from the van der Waals interaction between the sliding block and...

Effects of water flow on submerged macrophyte-biofilm systems in constructed wetlands

Lakes, College of Environment, Hohai University, Nanjing, 210098, ChinaBing Han, Songhe Zhang, Peifang Wang & Chao Wang AuthorsSearch for Bing Han in:Nature Research journals • PubMed • Google Scholar ... Search for Songhe Zhang in:Nature Research journals • PubMed • Google Scholar Search for Peifang Wang in:Nature Research journals • PubMed • Google Scholar Search for Chao Wang in:Nature Research

Mutation load estimation model as a predictor of the response to cancer immunotherapy

Synthetic Biology, National Yang-Ming University, Taipei, 11221, TaiwanYu-Chao Wang AuthorsSearch for Guan-Yi Lyu in:Nature Research journals • PubMed • Google Scholar Search for Yu-Hsuan Yeh in:Nature ... Research journals • PubMed • Google Scholar Search for Yi-Chen Yeh in:Nature Research journals • PubMed • Google Scholar Search for Yu-Chao Wang in:Nature Research journals • PubMed • Google Scholar

Experimental Study of Key Effect Factors and Simulation on Oil Displacement Efficiency for a Novel Modified Polymer BD-HMHEC

A novel synthetic hydrophobically modified hydroxyethyl cellulose (HEC) using bromododecane (BD) was developed in our previous paper, which we denote as BD-HMHEC. A series of one dimensional core displacement experiments were continually conducted to evaluate the key effect factors on the resistance factor (FR) and residual resistance factor (FRR) of BD-HMHEC solution, including...

Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory

. 31600920, 91232718, and 91132301), the Beijing Nova Program (Grant No. 2010B06), and the Natural Science Foundation of SZU (Grant No. 2016071). Author information Author notes Chao Wang and Bing Liu ... AuthorsSearch for Chao Wang in:Nature Research journals • PubMed • Google Scholar Search for Bing Liu in:Nature Research journals • PubMed • Google Scholar Search for Xiaolong Zhang in:Nature Research journals

Cross-coupling polycondensation via C–O or C–N bond cleavage

π-Conjugated polymers are widely used in optoelectronics for fabrication of organic photovoltaic devices, organic light-emitting diodes, organic field effect transistors, and so on. Here we describe the protocol for polycondensation of bifunctional aryl ethers or aryl ammonium salts with aromatic dimetallic compounds through cleavage of inert C–O/C–N bonds. This reaction proceeds...

The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine

Chenhai Liu Zhen Liu Futao Meng Chao Wang Qiang Huang OPEN As one of the most fatal malignancies, pancreatic ductal adenocarcinoma (PDAC) has significant resistance to the currently available treatment

Evaporative deposition of polystyrene microparticles on PDMS surface

Evaporation of water and ethanol/water droplets containing large polystyrene (PS) microparticles on polydimethylsiloxane (PDMS) surface was experimentally investigated. It is found that no matter with or without small addition of ethanol, a compact monolayer deposition is formed for lower microparticle concentration while mountain-like deposition for higher concentration. Since...

The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Epstein–Barr virus (EBV) can infect cells in latent and lytic period and cause serious disease. Epstein–Barr virus nuclear antigen 1 (EBNA1) is essential for the maintenance of the EBV DNA episome, replication and transcription. 2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its...

Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury

Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA and the underlying mechanisms. We found that ITF significantly...

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases. Here, we show that Ori is a specific and covalent inhibitor...

Direct observation of tin sites and their reversible interconversion in zeolites by solid-state NMR spectroscopy

Metal-substituted zeolites are an important type of solid Lewis acid with a wide range of applications. Despite the importance of this type of catalyst, identifying active sites can be challenging because different types of metal sites experience similar environments in zeolites. Here we show direct observation of different tin sites in Sn-β zeolite. Two types of open tin sites...

Evidence that CA3 is Underling the Comorbidity Between Pain and Depression and the Co-curation by Wu-Tou decoction in Neuropathic Pain

, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaChunyan Zhu, Qionghong Xu, Chao Wang, Zhiyun Mao & Na Lin AuthorsSearch for Chunyan Zhu in:Nature Research journals • PubMed • Google ... Scholar Search for Qionghong Xu in:Nature Research journals • PubMed • Google Scholar Search for Chao Wang in:Nature Research journals • PubMed • Google Scholar Search for Zhiyun Mao in:Nature Research

MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN

-chao Wang HuiYao Ke-zhu Hou Fang-ming Gu Xuan-fu Xu Recent studies have shown that miR-494-3p is oncogene and has a central role in many solid tumors; however, the role of miR-494-3p in the progression ... Foundation of China, No.: 81472689. Author Contributions Ke-zhu Hou, Fang-ming Gu and Xuan-fu Xu conceived the study and designed the experiments. Yuan-ping Tao, Meng-chao Wang and Hui Yao performed the

Molecular mechanisms of tannin accumulation in Rhus galls and genes involved in plant-insect interactions

For galling aphids and their hosts, tannins are crucial for plant-insect interactions and for protecting the host plant from herbivory. Due to their peculiar chemical characteristics, tannins from plant galls have been used for medical and chemical purposes for more than 2000 years. In this study, hydrolyzable tannin concentrations in galls increased from gall initiation (38.34...

Shift in bacterioplankton diversity and structure: Influence of anthropogenic disturbances along the Yarlung Tsangpo River on the Tibetan Plateau, China

Chao Wang Lingzhan Miao Jun Hou QiushengYuan OPEN Published: xx xx xxxx River systems have critical roles in the natural water environment and the transportation of nutrients. Anthropogenic activities

Ascorbic acid induces global epigenetic reprogramming to promote meiotic maturation and developmental competence of porcine oocytes

L-ascorbic acid (Vitamin C) can enhance the meiotic maturation and developmental competence of porcine oocytes, but the underlying molecular mechanism remains obscure. Here we show the role of ascorbic acid in regulating epigenetic status of both nucleic acids and chromatin to promote oocyte maturation and development in pigs. Supplementation of 250 μM L-ascorbic acid 2-phosphate...

Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments

3D microenvironmental parameters control cell behavior, but can be challenging to investigate over a wide range of conditions. Here, a combinatorial hydrogel platform is developed that uses light-mediated thiol-norbornene chemistry to encapsulate cells within hydrogels with biochemical gradients made by spatially varied light exposure. Specifically, mesenchymal stem cells are...

Theoretical Study of Sesterfisherol Biosynthesis: Computational Prediction of Key Amino Acid Residue in Terpene Synthase

Wang & Masanobu UchiyamaElements Chemistry Laboratory, RIKEN, and RIKEN Center for Sustainable Resource Science (Wako campus), 2–1 Hirosawa, Wako-shi, Saitama-ken, 351–0198, JapanHajime Sato, Chao Wang ... Atsushi Minami in:Nature Research journals • PubMed • Google Scholar Search for Mami Yamazaki in:Nature Research journals • PubMed • Google Scholar Search for Chao Wang in:Nature Research journals