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12 papers found.
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Cross-coupling polycondensation via C–O or C–N bond cleavage

π-Conjugated polymers are widely used in optoelectronics for fabrication of organic photovoltaic devices, organic light-emitting diodes, organic field effect transistors, and so on. Here we describe the protocol for polycondensation of bifunctional aryl ethers or aryl ammonium salts with aromatic dimetallic compounds through cleavage of inert C–O/C–N bonds. This reaction proceeds...

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases. Here, we show that Ori is a specific and covalent inhibitor...

Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments

3D microenvironmental parameters control cell behavior, but can be challenging to investigate over a wide range of conditions. Here, a combinatorial hydrogel platform is developed that uses light-mediated thiol-norbornene chemistry to encapsulate cells within hydrogels with biochemical gradients made by spatially varied light exposure. Specifically, mesenchymal stem cells are...

An integrative method to decode regulatory logics in gene transcription

, University of Hong Kong, Hong Kong, ChinaBin Yan & Kenneth R. BohelerSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong, ChinaDaogang Guan, Chao Wang, Bing He, Aiping Lu, Ge Zhang & Hailong ... ZhuInstitute of Integrated Bioinformedicine and Translational Science, Hong Kong Baptist University, Hong Kong, ChinaDaogang Guan, Chao Wang, Bing He, Aiping Lu, Ge Zhang & Hailong ZhuDepartment of Health

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

215123, ChinaQian Chen, Ligeng Xu, Chao Liang, Chao Wang, Rui Peng & Zhuang Liu AuthorsSearch for Qian Chen in:Nature Research journals • PubMed • Google ScholarSearch for Ligeng Xu in:Nature Research ... journals • PubMed • Google ScholarSearch for Chao Liang in:Nature Research journals • PubMed • Google ScholarSearch for Chao Wang in:Nature Research journals • PubMed • Google ScholarSearch for Rui Peng

The genetic prehistory of the Baltic Sea region

While the series of events that shaped the transition between foraging societies and food producers are well described for Central and Southern Europe, genetic evidence from Northern Europe surrounding the Baltic Sea is still sparse. Here, we report genome-wide DNA data from 38 ancient North Europeans ranging from ~9500 to 2200 years before present. Our analysis provides genetic...

DELLA proteins are common components of symbiotic rhizobial and mycorrhizal signalling pathways

for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, ChinaYue Jin, Huan Liu, Dexian Luo, Wentao Dong, Chao Wang, Xiaowei Zhang, Huiling Dai, Jun Yang & Ertao WangUniversity of Chinese ... • Google ScholarSearch for Nan Yu in:Nature Research journals • PubMed • Google ScholarSearch for Wentao Dong in:Nature Research journals • PubMed • Google ScholarSearch for Chao Wang in:Nature Research

Ancient Egyptian mummy genomes suggest an increase of Sub-Saharan African ancestry in post-Roman periods

Institute for the Science of Human History, 07745 Jena, GermanyAlexander Peltzer, Chuan-Chao Wang, Wolfgang Haak, Stephan Schiffels & Johannes KrauseDivision of Archaeology, University of Cambridge, Cambridge ... in:Nature Research journals • PubMed • Google ScholarSearch for Martyna Molak in:Nature Research journals • PubMed • Google ScholarSearch for Chuan-Chao Wang in:Nature Research journals • PubMed • Google

NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression

N-α-acetyltransferase D (NatD) mediates N-α-terminal acetylation (Nt-acetylation) of histone H4 known to be involved in cell growth. Here we report that NatD promotes the migratory and invasive capabilities of lung cancer cells in vitro and in vivo. Depletion of NatD suppresses the epithelial-to-mesenchymal transition (EMT) of lung cancer cells by directly repressing the...

Edge-mediated skyrmion chain and its collective dynamics in a confined geometry

• Google ScholarSearch for Chiming Jin in:Nature Research journals • PubMed • Google ScholarSearch for Chao Wang in:Nature Research journals • PubMed • Google ScholarSearch for Jiyong Yang in:Nature Research

Aridity threshold in controlling ecosystem nitrogen cycling in arid and semi-arid grasslands

, School of Environment, Tsinghua University, Beijing 100084, ChinaJizhong Zhou AuthorsSearch for Chao Wang in:Nature Research journals • PubMed • Google ScholarSearch for Xiaobo Wang in:Nature Research