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Clinical diagnosis and mutation analysis of four Chinese families with succinic semialdehyde dehydrogenase deficiency

Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal recessively-inherited defect of γ-aminobutyric acid (GABA) metabolism. The absence of SSADH, which is encoded by aldehyde dehydrogenase family 5 member A1 (ALDH5A1) gene, leads to the accumulation of GABA and γ-hydroxybutyric acid (GHB). Few cases with SSADH deficiency were reported in China. In this study...

Safety and efficacy of bone marrow-derived cells therapy on cardiomyopathy: a meta-analysis

-systolic volume MACE Major adverse cardiovascular event MlHFQ Minnesota Living with Heart Failure Questionnaire SPECT Single-photon emission-computed tomography WMD Weighted mean difference Chao Wang and

Development and validation of a risk prediction score for severe acute pancreatitis

, Vincent Zimmer†4, 5, Evangelos Kontopantelis†6, 7, Simon Stock8, Maddalena Zippi†9, Chao Wang†10 and Mengtao Zhou11Email author †Contributed equally Journal of Translational Medicine201917:146 https ... application of it on admission may improve clinical care and management strategies in acute pancreatitis. Notes Wandong Hong, Vincent Zimmer, Evangelos Kontopantelis, Maddalena Zippi and Chao Wang

Subloading Surface Model and Experimental Study of Coal Failure under Cyclic Loading

The fatigue damage of rock is an important factor affecting the stability of rock structure. In this paper, the mechanical response of coal under cyclic loading was studied. In order to accurately describe the deformation characteristics of coal under cyclic loading, an elastic-plastic model of coal based on the theory of subloading surface was established and verified by...

Parameter study of sound energy distribution in cuboid extra-large spaces

The aim of this paper is to explore the sound energy distribution in cuboid extra-large spaces. The surface absorption and height are studied as the parameters using the image method. Air absorption is also discussed in this paper. The results show that the difficulty of reducing the noise increases with the increasing volume in extra-large spaces. Even if the ratio between the...

Development of a novel autonomous lower extremity exoskeleton robot for walking assistance

Today, exoskeletons are widely applied to provide walking assistance for patients with lower limb motor incapacity. Most existing exoskeletons are under-actuated, resulting in a series of problems, e.g., interference and unnatural gait during walking. In this study, we propose a novel intelligent autonomous lower extremity exoskeleton (Auto-LEE), aiming at improving the user...

Friend and POI recommendation based on social trust cluster in location-based social networks

Friend and point-of-interest (POI) recommendation are two primary individual services in location-based social networks (LBSNs). Major social platforms such as Foursquare and Instagram are all capable of recommending friends or POIs to individuals. However, most of these social websites make recommendations only based on similarity, popularity, or geographical influence; social...

Concrete Compression Test Data Estimation Based on a Wavelet Neural Network Model

Firstly, a genetic algorithm (GA) and simulated annealing (SA) optimized fuzzy c-means clustering algorithm (FCM) was proposed in this paper, which was developed to allow for a clustering analysis of the massive concrete cube specimen compression test data. Then, using an optimized error correction time series estimation method based on the wavelet neural network (WNN), a...

Efficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial

Efficacy and safety of Tongfu powder in acute pancreatitis patients with gastrointestinal dysfunction: a clinical trial Bin Miao, Feng-Wu Li, Shu-Wen Zhang, Hong Wang, Wen-Jie Qi, Chao Wang

Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer

Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis and metastasis has not yet been fully elucidated. We determined the significance of CHI3L1 expression in patients with GC. We also explored an as-yet unknown receptor of CHI3L1 and investigated the involved...

Solving a Large-Scale Multi-Depot Vehicle Scheduling Problem in Urban Bus Systems

This study proposes an improved model and algorithm for the large-scale multi-depot vehicle scheduling problem (MDVSP) with departure-duration restrictions. In this study, the time-space network is applied to model the large-scale MDVSP. Considering that crews usually change shifts in the depot, departure-duration restrictions are added to the classic set-partitioning model to...

MiR-494-3p promotes PI3K/AKT pathway hyperactivation and human hepatocellular carcinoma progression by targeting PTEN

-chao Wang HuiYao Ke-zhu Hou Fang-ming Gu Xuan-fu Xu Recent studies have shown that miR-494-3p is oncogene and has a central role in many solid tumors; however, the role of miR-494-3p in the progression ... Foundation of China, No.: 81472689. Author Contributions Ke-zhu Hou, Fang-ming Gu and Xuan-fu Xu conceived the study and designed the experiments. Yuan-ping Tao, Meng-chao Wang and Hui Yao performed the

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases. Here, we show that Ori is a specific and covalent inhibitor...

The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein–Barr virus by inhibiting the molecular chaperone function of Hsp70

Epstein–Barr virus (EBV) can infect cells in latent and lytic period and cause serious disease. Epstein–Barr virus nuclear antigen 1 (EBNA1) is essential for the maintenance of the EBV DNA episome, replication and transcription. 2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its...

Molecular mechanisms of tannin accumulation in Rhus galls and genes involved in plant-insect interactions

For galling aphids and their hosts, tannins are crucial for plant-insect interactions and for protecting the host plant from herbivory. Due to their peculiar chemical characteristics, tannins from plant galls have been used for medical and chemical purposes for more than 2000 years. In this study, hydrolyzable tannin concentrations in galls increased from gall initiation (38.34...

A new technique for nanoparticle transport and its application in a novel nano-sieve

A new technique is proposed to transport and further classify nanoparticles of different sizes. A graphene sheet is used as the substrate; a nanoparticle is placed on the substrate and a sliding block is located below the substrate. As the sliding block moves under the graphene substrate, a driving force is yielded from the van der Waals interaction between the sliding block and...

A new Monte Carlo mobile node localization algorithm based on Newton interpolation

There are some deficiencies in the Monte Carlo localization algorithm based on rangefinder, which like location probability distribution of the k moment in the prediction phase only related to the localization of the k − 1 moment and the maximum and minimum velocity. And the influences of the motion condition on the movement of the mobile node at k moment are also not considered...

Computational study on a puzzle in the biosynthetic pathway of anthocyanin: Why is an enzymatic oxidation/ reduction process required for a simple tautomerization?

Uchiyama. Funding acquisition: Mami Yamazaki, Kazuki Saito, Masanobu Uchiyama. Formal analysis: Hajime Sato. Supervision: Masanobu Uchiyama. Project administration: Chao Wang, Masanobu Uchiyama. Writing ... ± original draft: Hajime Sato, Chao Wang. 1. Feild TS , Lee DW , Holbrook NM . Why Leaves Turn Red in Autumn. The Role of Anthocyanins in Senescing Leaves of Red-Osier Dogwood . Plant Physiol . 2001 ; 127