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Four 14(13 → 12)-Abeolanostane Triterpenoids with 6/6/5/6-Fused Ring System from the Roots of Kadsura coccinea

Four new rearranged 6/6/5/6-fused lanostane-type triterpenoids, kadcoccitanes A–D (1–4), were isolated from the roots of Kadsura coccinea, and their structures were mainly elucidated by comprehensive analysis of their spectroscopic data. Additionally, the structure of 1 was ambiguously verified by single-crystal X-ray diffraction, while the structure of 2, which features a novel...

LP Relaxation and Tree Packing for Minimum k-cuts

Karger used spanning tree packings [Karger, 2000] to derive a near linear-time randomized algorithm for the global minimum cut problem as well as a bound on the number of approximate minimum cuts. This is a different approach from his well-known random contraction algorithm [Karger, 1995; Karger and Stein, 1996]. Thorup developed a fast deterministic algorithm for the minimum k...

A Negotiation Optimization Strategy of Collaborative Procurement with Supply Chain Based on Multi-Agent System

In the process of collaborative procurement, buyers and suppliers are prone to conflict in cooperation due to differences in needs and preferences. Negotiation is a crucial way to resolve the conflict. Aimed at ameliorating the situations of underdeveloped self-adaptive learning effect of current collaborative procurement negotiation, this paper constructs a negotiation model...

A Negotiation Optimization Strategy of Collaborative Procurement with Supply Chain Based on Multi-Agent System

, Zhejiang 310018, China Correspondence should be addressed to Chao Xu; moc.361@udh_uxoahc Received 13 March 2018; Revised 29 July 2018; Accepted 5 August 2018; Published 26 August 2018 Academic Editor ... : Luciano Caroprese Copyright © 2018 Chouyong Chen and Chao Xu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

Soft tissue restrictors of femoral elevation in direct anterior approach—an anatomic study

With the patient in a constant supine position, elevation of the femur in THA (DAA) provides a more intuitive and conducive location of the acetabulum for the correct placement of the acetabular prosthesis, but elevation of the femur for broaching becomes more challenging. The purpose of this study is to analyze the restriction of the ischiofemoral ligament and short external...

Meta-Analysis of Genome-Wide Association Studies Identifies Novel Functional CpG-SNPs Associated with Bone Mineral Density at Lumbar Spine

Osteoporosis is a serious public health issue, which is mostly characterized by low bone mineral density (BMD). To search for additional genetic susceptibility loci underlying BMD variation, an effective strategy is to focus on testing of specific variants with high potential of functional effects. Single nucleotide polymorphisms (SNPs) that introduce or disrupt CpG dinucleotides...

A Modified Time Reversal Method for Guided Wave Detection of Bolt Loosening in Simulated Thermal Protection System Panels

In this work, a modified time reversal method is proposed for guided wave detection and localizing loosened bolt in a complicated multibolt-jointed structure. Different from the traditional time reversal guided wave method, the response signal due to a tone burst input received at the healthy state is time reversed and recorded as a standard reemitting signal. In the detection...

A Modified Time Reversal Method for Guided Wave Detection of Bolt Loosening in Simulated Thermal Protection System Panels

, Northwestern Polytechnical University, Xi’an 710072, China 2Mechanical Engineering Department, University of Maryland, Baltimore County, Baltimore, MD 21250, USA Correspondence should be addressed to Chao Xu

Detection of rice sheath blight using an unmanned aerial system with high-resolution color and multispectral imaging

), and the Science and Technology Development Program of Anhui Province (1604A0702016). Author Contributions Formal analysis: Dongyan Zhang, Jian Zhang. Funding acquisition: Chao Xu, Dong Liang ... . Investigation: Dongyan Zhang, Xingen Zhou, Jian Zhang. Methodology: Dongyan Zhang, Yubin Lan, Chao Xu. Supervision: Dong Liang. Writing ± review & editing: Xingen Zhou. 13 / 14 1. RPH. Rice Production Handbook

Synthesis, Characterization of Nano-β-Tricalcium Phosphate and the Inhibition on Hepatocellular Carcinoma Cells

interest. Authors’ Contributions Langlang Liu and Yanzeng Wu conceived and designed the experiments. Langlang Liu, Yanzeng Wu, Chao Xu, and Suchun Yu performed the experiments. Langlang Liu and Yanzeng Wu

Synthesis, Characterization of Nano-β-Tricalcium Phosphate and the Inhibition on Hepatocellular Carcinoma Cells

interest. Authors’ Contributions Langlang Liu and Yanzeng Wu conceived and designed the experiments. Langlang Liu, Yanzeng Wu, Chao Xu, and Suchun Yu performed the experiments. Langlang Liu and Yanzeng Wu

Synthesis, Characterization of Nano-β-Tricalcium Phosphate and the Inhibition on Hepatocellular Carcinoma Cells

interest. Authors’ Contributions Langlang Liu and Yanzeng Wu conceived and designed the experiments. Langlang Liu, Yanzeng Wu, Chao Xu, and Suchun Yu performed the experiments. Langlang Liu and Yanzeng Wu

Synthesis, Characterization of Nano-β-Tricalcium Phosphate and the Inhibition on Hepatocellular Carcinoma Cells

interest. Authors’ Contributions Langlang Liu and Yanzeng Wu conceived and designed the experiments. Langlang Liu, Yanzeng Wu, Chao Xu, and Suchun Yu performed the experiments. Langlang Liu and Yanzeng Wu

An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer

Pancreatic cancer is a deadly disease with a very low 5-year patient survival rate of 6–8%. The major challenges of eliminating pancreatic cancer are treatment resistance and stromal barriers to optimal drug access within the tumor. Therefore, effective molecular targeting drugs with high intra-tumor access and retention are urgently needed for managing this devastating disease...

Convergence of a linearly extrapolated BDF2 finite element scheme for viscoelastic fluid flow

The stability and convergence of a linearly extrapolated second order backward difference (BDF2-LE) time-stepping scheme for solving viscoelastic fluid flow in R d $\mathbb{R}^{d}$ , d = 2 , 3 $d=2,3$ , are presented in this paper. The time discretization is based on the implicit scheme for the linear term and the two-step linearly extrapolated scheme for the nonlinear term...

Rare variant association analysis in case-parents studies by allowing for missing parental genotypes

The development of next-generation sequencing technologies has facilitated the identification of rare variants. Family-based design is commonly used to effectively control for population admixture and substructure, which is more prominent for rare variants. Case-parents studies, as typical strategies in family-based design, are widely used in rare variant-disease association...

A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research

Osteoporosis is a prevalent bone metabolic disease and peripheral blood monocytes represent a major systemic cell type for bone metabolism. To identify the key dysfunctional pathways in osteoporosis, we performed pathway analyses on microarray data of monocytes from subjects with extremely high/low hip bone mineral density. We first performed a traditional pathway analysis for...

The Synthesis of Size-Adjustable Superparamagnetism Fe3O4 Hollow Microspheres

One hundred fifty to 300-nm-sized monodisperse iron oxide (Fe3O4) hollow microspheres were synthesized by the one-pot hydrothermal method. The morphology and crystal structure of the as-prepared hollow microspheres was characterized by scanning electron microscopy, X-ray diffraction, transmission electron microscopy, and high-resolution transmission electron microscopy, while the...

Chemosensitizing indomethacin-conjugated dextran-based micelles for effective delivery of paclitaxel in resistant breast cancer therapy

Multidrug resistance (MDR) against chemotherapeutic agents has become the major obstacle to successful cancer therapy and multidrug resistance-associated proteins (MRPs) mediated drug efflux is the key factor for MDR. Indomethacin (IND), one of the non-steroidal anti-inflammatory agents, has been demonstrated to increase cytotoxic effects of anti-tumor agents as MRP substrates...

Global and Fixed-Terminal Cuts in Digraphs

The computational complexity of multicut-like problems may vary significantly depending on whether the terminals are fixed or not. In this work we present a comprehensive study of this phenomenon in two types of cut problems in directed graphs: double cut and bicut. 1. Fixed-terminal edge-weighted double cut is known to be solvable efficiently. We show that fixed-terminal node...