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Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes

, and Xin-ling DU designed the study; Huan WANG, Hao ZHANG, Chen WANG, and Yu-fang CHEN performed the experiments; Huan WANG and Rong MA analyzed the data; Hong-fei WANG, Chen WANG, and Yu-fang CHEN ... , Huazhong University of Science and Technology, Wuhan 430030, ChinaHuan Wang, Chen Wang, Yu-fang Chen, Rong Ma, Ji-zhou Xiang & Qiang TangDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical

Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis

-qin LI, and Jing-jing WEI designed the research; Hui-qin LI, Jing-jing WEI, Wan XIA, Ji-huang LI, Ai-ju LIU, Su-bing YIN, Chen WANG, Liang SONG, and Yan WANG performed the research; Hui-qin LI, Jing ... -jing WEI, Wan XIA, Ji-huang LI, Ai-ju LIU, Su-bing YIN, Chen WANG, Liang SONG, and Yan WANG analyzed the data; Hui-qin LI, Jing-jing WEI, Guo-qing ZHENG, and Ji-ping FAN wrote the paper. References

Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway

underscore its protection in oncosis and apoptosis where could be part of a therapeutic strategy to treat peri-operative ischemic events. Author contribution Chen WANG designed the research and provided ... the National Natural Science Foundation of China (Grant No 81372024 to Dr Jiang ZHU), the Technology Bureau of Suzhou, China (Grants No SYS201130, SYSD2012085, and KJXW2011015 to Dr Chen WANG; SYS201125

Factors Affecting the Mechanical Properties of Cement-Mixed Gravel

, Sichuan University, Chengdu 610065, China Received 6 July 2016; Revised 15 October 2016; Accepted 7 November 2016 Academic Editor: Stevulova Nadezda Copyright © 2016 Chen Wang and Wentao Li. This is an

Nanosericite as an Innovative Microparticle in Dual-Chemical Paper Retention Systems

Dual-chemical retention systems based on 2 cationic polyacrylamides, a colloidal silica, and a globular anionic polymer microparticles were investigated and an exfoliated nanoparticle indigenous mica mineral, sericite, was examined for its efficacy in substituting commercial microparticle preparations. The results indicated that nanosericite generated FPR between 76.9 and 80.9...

Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model

Background Blood purification is an emerging approach to dampening the cytokine storm. This study aims to assess the efficacy of HA330 resin-directed hemoadsorption (HA) on endotoxin-induced porcine acute respiratory distress syndrome (ARDS) model. Methods Twenty-four Chinese domestic pigs were allocated into saline group receiving intravenous infusion of saline (N = 6) and...

Cloning and molecular identification of triosephosphate isomerase gene from Apis cerana cerana and its role in response to various stresses

Apis cerana cerana triosephosphate isomerase (AccTPI), a key regulatory enzyme in glycolysis and gluconeogenesis pathway, catalyzes the interconversion of glyceraldehyde 3-phosphate to dihydroxyacetone phosphate. However, its role in A. cerana cerana has not been completely clarified. In this study, a TPI gene was cloned from A. cerana cerana and named AccTPI. The open reading...

Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA

A recent study found that CD177 served as a receptor of membrane-bound proteinase-3 (mPR3) in a subset of neutrophils. Furthermore, CD177 has been identified as a high-affinity heterophilic binding partner for the endothelial cell platelet endothelial cell adhesion molecule-1 (PECAM-1). The current study aimed to investigate whether the interaction between PECAM-1 and CD177 could...

High-mobility group box 1 potentiates antineutrophil cytoplasmic antibody-inducing neutrophil extracellular traps formation

Background Recent studies found that the circulating high-mobility group box 1 (HMGB1) levels could reflect the disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). HMGB1 could prime neutrophils by increasing ANCA antigens translocation for ANCA-mediated respiratory burst and degranulation. The current study aimed to investigate whether...

High mobility group box 1 contributes to anti-neutrophil cytoplasmic antibody-induced neutrophils activation through receptor for advanced glycation end products (RAGE) and Toll-like receptor 4

Introduction High mobility group box-1 (HMGB1), a typical damage-associated molecular pattern (DAMP) protein, is associated with inflammatory conditions and tissue damage. Our recent study found that circulating HMGB1 levels could reflect the disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The current study aimed to investigate whether...

Ginsenoside Rh1 potentiates dexamethasone’s anti-inflammatory effects for chronic inflammatory disease by reversing dexamethasone-induced resistance

Jun Li 0 Juan Du 0 Dong Liu Binbin Cheng Fanfu Fang Li Weng Chen Wang Changquan Ling 0 Equal contributors Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical

Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis

Introduction Increasing evidence has suggested that linear epitopes of antineutrophil cytoplasmic antibody (ANCA) directed to myeloperoxidase (MPO) might provide clues to the pathogenesis of propylthiouracil (PTU)-induced ANCA-associated vasculitis (AAV). This study mapped epitopes of MPO-ANCA in sera from patients with PTU-induced MPO-ANCA (with or without vasculitis) and...

Enhancing intervertebral disc repair and regeneration through biology: platelet-rich plasma as an alternative strategy

Shan-Zheng Wang 0 Yun-Feng Rui 0 Qi Tan Chen Wang 0 0 Department of Orthopaedics, Zhongda Hospital, Medical School of Southeast University , 87 Ding Jia Qiao Road, Nanjing, Jiangsu 210009 , China

Knowledge-guided gene ranking by coordinative component analysis

Chen Wang 0 Jianhua Xuan 0 Huai Li Yue Wang 0 Ming Zhan Eric P Hoffman Robert Clarke 0 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University

Motif-directed network component analysis for regulatory network inference

Background Network Component Analysis (NCA) has shown its effectiveness in discovering regulators and inferring transcription factor activities (TFAs) when both microarray data and ChIP-on-chip data are available. However, a NCA scheme is not applicable to many biological studies due to limited topology information available, such as lack of ChIP-on-chip data. We propose a new...

Knowledge-guided multi-scale independent component analysis for biomarker identification

Background Many statistical methods have been proposed to identify disease biomarkers from gene expression profiles. However, from gene expression profile data alone, statistical methods often fail to identify biologically meaningful biomarkers related to a specific disease under study. In this paper, we develop a novel strategy, namely knowledge-guided multi-scale independent...

Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

Background Non-attendance at gynecological clinics is a major limitation of cervical cancer screening and self-collection of samples may improve this situation. Although HPV testing of self-collected vaginal samples is acceptable, the specificity is inadequate. The current focus is increasing self-collection of vaginal samples to minimize clinic visits. In this study, we analyzed...

MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma

Background miR-182 is one of the most significantly up-regulated miRNAs in hepatocellular carcinoma (HCC). Metastasis suppressor 1 (MTSS1), one target gene of miR-182, plays an important role in the metastasis of cancers. However, it remains unclear what role does function and mechanism of miR-182 and MTSS1play in HCC. Methods miR-182 expression was tested in 86 cases of paired...

Clinical significance of Neutrophil gelatinase-associated lipocalin(NGAL) expression in primary rectal cancer

Background Emerging evidence has demonstrated that Neutrophil gelatinase-associated lipocalin (NGAL) is up-regulated in multiple malignancies, including oesophagus cancer, and plays a critical role in tumorigenesis and progression. However, till now, little is known about the role of NGAL in human rectal cancer. Its association with clinicopathologic characteristics and...

Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling

Background Recently, evidence indicated that the rapamycin-eluting stent which was used worldwide may contribute to an increased risk for thrombosis. On the contrary, other researchers found it was safe. Thus, it is necessary to clarify the effect of rapamycin on thrombosis and the corresponding mechanisms. Results The effects of rapamycin in vivo were evaluated by modified deep...