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Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Jocelyne Chiquette Laima Tihomirova Tara M. Friebel Bjarni A. Agnarsson Karen H. Lu Flavio Lejbkowicz Paul A. James Per Hall Alison M. Dunning Daniel Tessier Julie Cunningham Susan L. Slager Chen Wang Steven ... Damiola, Catherine Houghton, Alex Murray, Jan Lubinski, Conxi Lazaro, Christine Walsh, Chen Wang, Jenny Lester, Huw Dorkins, Helmut Deissler, Ian Campbell, Isabelle Coupier, Judith Balma na, Joan Brunet

Effects of magnesium and ionic strength on the diffusion and charge properties of several single tRNA species

Kee Woo Rhee 1 Russell O.Pottst 1 Chun-Chen Wang" Maurille J.Fournier Norman C. Ford 0 Biochemistry, University of Massachusetts , Amherst, MA 01003 , USA 1 Present addresses: K.W.R.-Biophysics

Inherited Variants in Regulatory T Cell Genes and Outcome of Ovarian Cancer

Although ovarian cancer is the most lethal of gynecologic malignancies, wide variation in outcome following conventional therapy continues to exist. The presence of tumor-infiltrating regulatory T cells (Tregs) has a role in outcome of this disease, and a growing body of data supports the existence of inherited prognostic factors. However, the role of inherited variants in genes...

Antiviral Therapy and Outcomes of Patients with Pneumonia Caused by Influenza A Pandemic (H1N1) Virus

Chen Wei-bo Du Xi-xin Yan Zong-an Liang Wei Zhang Chang-le Zhang Wei Chen Cai-ping Guo Xun-liang Jiang Ming Yang Guang-ming Deng Kai-jiang Yu Ke Hu Qi Zou Lan-juan Li Chen Wang for the National Influenza


INTRODUCTION: Using ventricoluperitoneal shunt before the resection of pediatric posterior fossa brain tumors, presenting with hydrocephalus used to be common practice, but most centers now are abandoning this policy due to the complications associated with the shunt. MATERIAL AND METHODS: We report retrospectively on the short term outcome of posterior fossa brain tumour in...

Differences in mutant p53 protein stability and functional activity in teniposide-sensitive and -resistant human leukemic CEM cells

, Department of Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, IL 60607, USASusan E Morgan, Pu Chen Wang, Uppoor G Bhat & William T BeckDepartment of Surgical Oncology, Hiroshima ... ScholarSearch for Ryungsa Kim in:Nature Research journals • PubMed • Google ScholarSearch for Pu Chen Wang in:Nature Research journals • PubMed • Google ScholarSearch for Uppoor G Bhat in:Nature Research journals

A convenient method of aligning large DNA molecules on bare mica surfaces for atomic force microscopy

Large DNA molecules remain difficult to be imaged by atomic force microscopy (AFM) because of the tendency of aggregation. A method is described to align long DNA fibers in a single direction on unmodified mica to facilitate AFM studies. The clear background, minimal overstretching, high reproducibility and convenience of this aligning procedure make it useful for physical...

The observation of the local ordering characteristics of spermidine-condensed DNA: Atomic force microscopy and polarizing microscopy studies

Condensation of DNA by multivalent cations can provide useful insights into the physical factors governing the folding and packaging of DNA in vivo. In this work, local ordered structures of spermidine-DNA complexes prepared from different DNA concentrations have been examined by using atomic force microscopy (AFM) and polarizing microscopy (PM). Two types (I and II) of DNA...

Screening mutations of OTOF gene in Chinese patients with auditory neuropathy, including a familial case of temperature-sensitive auditory neuropathy

Background Mutations in OTOF gene, encoding otoferlin, cause DFNB9 deafness and non-syndromic auditory neuropathy (AN). The aim of this study is to identify OTOF mutations in Chinese patients with non-syndromic auditory neuropathy. Methods 73 unrelated Chinese Han patients with AN, including one case of temperature sensitive non-syndromic auditory neuropathy (TS-NSRAN) and 92...

Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke

Introduction Statins reportedly have anti-inflammatory and anti-thrombotic effects aside from cholesterol-lowering. This study aimed to evaluate the effect of pre-existing statin use on platelet activation markers and clinical outcome in acute ischemic stroke patients. Methods This prospective study evaluated 172 patients with acute ischemic stroke divided in two groups: patients...

Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel

4 Devin C. Koestler 6 Brooke L. Fridley 5 Kimberly R. Kalli 2 Sebastian M. Armasu 4 Melissa C. Larson 4 Chen Wang 4 Stacey J. Winham 4 Robert A. Vierkant 4 David N. Rider 4 Matthew S. Block 0 Brandy

Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities

Silverman,13 Jae Seung Lee,1 Ting Yang,14 Yingxiang Lin,14 Chen Wang,14 Sang-Do Lee1  1Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases ... Hironi Makita 13 Edwin K Silverman 10 Jae Seung Lee 3 Ting Yang 11 Yingxiang Lin 11 Chen Wang 11 Sang-Do Lee 3 0 Department of Medicine, Khon Kaen University , Khon Kaen , Thailand 1 Department of

Comparison of Patients Hospitalized With Influenza A Subtypes H7N9, H5N1, and 2009 Pandemic H1N1

Background. Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression of patients hospitalized with H7N9, H5N1, and 2009 pandemic H1N1 (pH1N1) virus infections. Methods. We compared individual-level data...

Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma

-Yen Chien Fu-Min Fang, Chih-Cheng Huang, Hsueh-Wen Chang, Wen-Neng Chang, Chi-Ren Huang, Nai-Wen Tsai, Chia-Te Kung, Hung-Chen Wang, Wei-Che Lin, Yu-Jun Lin, Ben-Chung Cheng, Yu-Jih Su, Ya-Ting Chang

Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine

The application of nanomaterial in cancer treatment is promising and intriguing. Anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of immunotherapy generally needs further improvement. One way to improve the efficacy is using immune adjuvants, but the adjuvants for anticancer immunotherapy have to be more...

Predictors and outcomes of shunt-dependent hydrocephalus in patients with aneurysmal sub-arachnoid hemorrhage

BackgroundHydrocephalus following spontaneous aneurysmal sub-arachnoid hemorrhage (SAH) is often associated with unfavorable outcome. This study aimed to determine the potential risk factors and outcomes of shunt-dependent hydrocephalus in aneurysmal SAH patients but without hydrocephalus upon arrival at the hospital.MethodsOne hundred and sixty-eight aneurysmal SAH patients were...

Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China

Peng-jun Zhang Xiao-li Li Bin Cao Shi-gui Yang 0 Li-rong Liang Li Gu Zhen Xu Ke Hu Hong-yuan Zhang Xi-xin Yan Wen-bao Huang Wei Chen Jing-xiao Zhang Lan-juan Li 0 Chen Wang 1 for for the National

Delayed minocycline but not delayed mild hypothermia protects against embolic stroke

Background Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study, effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia on focal embolic cerebral ischemia have been examined. Methods Focal ischemic injury was induced by embolizing a preformed clot into the middle cerebral...