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QTL analysis of cocoon shell weight identifies BmRPL18 associated with silk protein synthesis in silkworm by pooling sequencing

Gao Minjin Han Gao Xiong Tingting Gai Hai Hu Fangyin Dai Cheng Lu OPEN Mechanisms that regulate silk protein synthesis provide the basis for silkworm variety breeding and silk gland bioreactor ... mapping population design; Fangyin Dai: Experimental design, material and mapping population design and manuscript review, Cheng Lu: Experimental design and manuscript review. Additional Information

Coupled grain boundary motion in aluminium: the effect of structural multiplicity

The shear-induced coupled grain boundary motion plays an important role in the deformation of nanocrystalline (NC) materials. It has been known that the atomic structure of the grain boundary (GB) is not necessarily unique for a given set of misorientation and inclination of the boundary plane. However, the effect of the structural multiplicity of the GB on its coupled motion has...

Multi-Pass Adaptive Voting for Nuclei Detection in Histopathological Images

Nuclei detection is often a critical initial step in the development of computer aided diagnosis and prognosis schemes in the context of digital pathology images. While over the last few years, a number of nuclei detection methods have been proposed, most of these approaches make idealistic assumptions about the staining quality of the tissue. In this paper, we present a new...

Probing the structural evolution of ruthenium doped germanium clusters: Photoelectron spectroscopy and density functional theory calculations

• PubMed • Google ScholarSearch for Cheng Lu in:Nature Research journals • PubMed • Google ScholarSearch for Hongguang Xu in:Nature Research journals • PubMed • Google ScholarSearch for Weijun Zheng ... Kuang or Cheng Lu or Hongguang Xu. Supplementary information Word documents1.Supplementary Information Rights and permissions This work is licensed under a Creative Commons Attribution 4.0

Superstrength of nanograined steel with nanoscale intermetallic precipitates transformed from shock-compressed martensitic steel

, AustraliaHailiang Yu, Cheng Lu, Anh Kiet Tieu, Huijun Li, Qiang Zhu, Ajit Godbole, Jintao Li & Lihong SuDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen ... ScholarSearch for Ming Yan in:Nature Research journals • PubMed • Google ScholarSearch for Cheng Lu in:Nature Research journals • PubMed • Google ScholarSearch for Anh Kiet Tieu in:Nature Research journals

A combined experimental-numerical approach for determining mechanical properties of aluminum subjects to nanoindentation

A crystal plasticity finite element method (CPFEM) model has been developed to investigate the mechanical properties and micro-texture evolution of single-crystal aluminum induced by a sharp Berkovich indenter. The load-displacement curves, pile-up patterns and lattice rotation angles from simulation are consistent with the experimental results. The pile-up phenomenon and lattice...

Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma

Recent reports show that B7-H4 is highly expressed in a variety of tumor cells, functions as a negative regulator of T cells and then promotes tumor progression. However, its expression and role in intrahepatic cholangiocarcinoma (ICC) remain unclear. In present study, B7-H4 expression in ICC and peritumoral tissues was determined at the level of mRNA and protein, and its...

A protein fragment derived from DNA-topoisomerase I as a novel tumour-associated antigen for the detection of early stage carcinoma

Background:The production of autoantibodies against tumour-associated antigens (TAAs) is believed to reflect greater immunologic reactivity in cancer patients and enhanced immune surveillance for cancer cells. Over the past few decades, a number of different TAAs and their corresponding autoantibodies have been investigated. However, positive frequency of autoantibody detection...

Problems and Solutions in Click Chemistry Applied to Drug Probes

Small-molecule fluorescent probes have been widely used in target identification, but this method has many disadvantages. For example, the identified proteins are usually complex, and additional biochemical studies are needed to distinguish real targets from interference results. To address this problem, we propose a series of strategies for improving the efficiency of target...

A new insight into ductile fracture of ultrafine-grained Al-Mg alloys

AffiliationsSchool of Mechanical, Materials & Mechatronics Engineering, University of Wollongong, Wollongong, NSW 2500, AustraliaHailiang Yu, A. Kiet Tieu, Cheng Lu, Xiong Liu, Mao Liu & Ajit GodboleElectron ... Hailiang Yu in:Nature Research journals • PubMed • Google ScholarSearch for A. Kiet Tieu in:Nature Research journals • PubMed • Google ScholarSearch for Cheng Lu in:Nature Research journals • PubMed • Google

Epigenetic map and genetic map basis of complex traits in cassava population

Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, ChinaMeiling Zou, Cheng Lu, Shengkui Zhang, Qing Chen, Xianglai Sun, Pingan Ma, Meizhen Hu, Ming ... WangGuangxi Academy of Agricultural Sciences, Guilin, ChinaDayong Fan, Bin Zhou, Chunling Wu & Ming Su AuthorsSearch for Meiling Zou in:Nature Research journals • PubMed • Google ScholarSearch for Cheng Lu

Hydrogen peroxide primes heart regeneration with a derepression mechanism

While the adult human heart has very limited regenerative potential, the adult zebrafish heart can fully regenerate after 20% ventricular resection. Although previous reports suggest that developmental signaling pathways such as FGF and PDGF are reused in adult heart regeneration, the underlying intracellular mechanisms remain largely unknown. Here we show that H2O2 acts as a...

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

, Chao Liang, Lei Dang, Cheng Lu, Bing He, Biao Liu, Atik Badshah Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, Zhaoxiang Bian, Hailong Zhu, Aiping Lu & Ge ZhangShenzhen Lab of Combinatorial Compounds and ... • PubMed • Google ScholarSearch for Chao Liang in:Nature Research journals • PubMed • Google ScholarSearch for Lei Dang in:Nature Research journals • PubMed • Google ScholarSearch for Cheng Lu in:Nature

hBUB1 defects in leukemia and lymphoma cells

ChinaHon Yu RuInstitute of Human Genetics, Tzu Chi University, Hualien, Taiwan, Republic of ChinaWe Cheng Lu & Ji Hshiung ChenInstitute of Molecular and Cell Biology, Tzu Chi University, Hualien, Taiwan ... ScholarSearch for Ron Long Chen in:Nature Research journals • PubMed • Google ScholarSearch for We Cheng Lu in:Nature Research journals • PubMed • Google ScholarSearch for Ji Hshiung Chen in:Nature Research

Downregulation of XIAP expression induces apoptosis and enhances chemotherapeutic sensitivity in human gastric cancer cells

X-linked inhibitor of apoptosis (XIAP) is the most potent member of the inhibitor of apoptosis protein (IAP) gene family in terms of its ability to inhibit caspases and suppress apoptosis. Recent evidence has suggested that XIAP is a key determinant in chemoresistance of cancer cells. To explore a novel approach for ameliorating chemotherapy of gastric cancer, the antisense...