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Rheumatoid Arthritis with Deficiency Pattern in Traditional Chinese Medicine Shows Correlation with Cold and Hot Patterns in Gene Expression Profiles

In our precious study, the correlation between cold and hot patterns in traditional Chinese medicine (TCM) and gene expression profiles in rheumatoid arthritis (RA) has been explored. Based on TCM theory, deficiency pattern is another key pattern diagnosis among RA patients, which leads to a specific treatment principle in clinical management. Therefore, a further analysis was...

Rheumatoid Arthritis with Deficiency Pattern in Traditional Chinese Medicine Shows Correlation with Cold and Hot Patterns in Gene Expression Profiles

In our precious study, the correlation between cold and hot patterns in traditional Chinese medicine (TCM) and gene expression profiles in rheumatoid arthritis (RA) has been explored. Based on TCM theory, deficiency pattern is another key pattern diagnosis among RA patients, which leads to a specific treatment principle in clinical management. Therefore, a further analysis was...

Understanding the Molecular Mechanism of Interventions in Treating Rheumatoid Arthritis Patients with Corresponding Traditional Chinese Medicine Patterns Based on Bioinformatics Approach

 Cheng Lu,1 Gao Chen,2 Cheng Xiao,3 Qinglin Zha,4 Xuyan Niu,1 Shilin Chen,5 and Aiping Lu1,6 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing 100700

Understanding the Molecular Mechanism of Interventions in Treating Rheumatoid Arthritis Patients with Corresponding Traditional Chinese Medicine Patterns Based on Bioinformatics Approach

 Cheng Lu,1 Gao Chen,2 Cheng Xiao,3 Qinglin Zha,4 Xuyan Niu,1 Shilin Chen,5 and Aiping Lu1,6 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing 100700

Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

Current strategies for drug discovery have reached a bottleneck where the paradigm is generally “one gene, one drug, one disease.” However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery. Based on network pharmacology, a combinational drug with two or more compounds could offer beneficial synergistic effects for complex diseases...

The Inhibitory Effect of Ellagic Acid on Cell Growth of Ovarian Carcinoma Cells

Ellagic acid (EA) is able to inhibit the growth of several cancer cells; however, its effect on human ovarian carcinoma cells has not yet been investigated. Ovarian carcinoma ES-2 and PA-1 cells were treated with EA (10~100 μM) and assessed for viability, cell cycle, apoptosis, anoikis, autophagy, and chemosensitivity to doxorubicin and their molecular mechanisms. EA inhibited...

Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

December 2011 Academic Editor: Lixing Lao Copyright © 2012 Cheng Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use ... Arthritis in Traditional Chinese Medicine Cheng Lu,1 Xuyan Niu,1 Cheng Xiao,2 Gao Chen,1,3 Qinglin Zha,4 Hongtao Guo,5 Miao Jiang,1 and Aiping Lu1,5 1Institute of Basic Research in Clinical Medicine, China

Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine

9 December 2011 Academic Editor: Lixing Lao Copyright © 2012 Cheng Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits

Traditional Chinese Medicine Zheng in the Era of Evidence-Based Medicine: A Literature Analysis

Zheng, which is also called a syndrome or pattern, is the basic unit and a key concept of traditional Chinese medicine (TCM) theory. Zheng can be considered a further stratification of patients when it is integrated with biomedical diagnoses in clinical practice to achieve higher efficacies. In an era of evidence-based medicine, confronted with the vast and increasing volume of...

A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

Academic Editor: Wei Jia Copyright © 2013 Cheng Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

Academic Editor: Wei Jia Copyright © 2013 Cheng Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and

The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney Deficiency

Androgens have been linked to the onset, severity, and progression of rheumatoid arthritis (RA). In traditional Chinese medicine (TCM), the most common pattern in RA is kidney deficiency, which partly corresponds to a low sex hormone state. In this study, TCM kidney deficiency was induced in male Sprague-Dawley rats with castration surgery, and a TCM preparation, Yi Shen Juan Bi...

Xiaoqinglong Granules as Add-On Therapy for Asthma: Latent Class Analysis of Symptom Predictors of Response

Xiaoqinglong granules (XQLG) has been shown to be an effective therapy in asthma animal models. We reviewed the literature and conducted this study to assess the impact of XQLG as an add-on therapy to treatment with fluticasone/salmeterol (seretide) in adult patients with mild-to-moderate, persistent asthma. A total of 178 patients were randomly assigned to receive XQLG and...

Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

 Qingsheng Shi,3 Tong Yang,4 Qingxiong Zhu,5 Yimei Tian,1 Cheng Lu,2 Zhiying Zhang,3 Zhongsheng Jiang,4 Hongying Zhou,3 Xiaofeng Wen,5 Huasheng Yang,1 Xiaorong Ding,2 Lanchun Liang,1 Yan Liu,2 Yongyan Wang,2

Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

 Qingsheng Shi,3 Tong Yang,4 Qingxiong Zhu,5 Yimei Tian,1 Cheng Lu,2 Zhiying Zhang,3 Zhongsheng Jiang,4 Hongying Zhou,3 Xiaofeng Wen,5 Huasheng Yang,1 Xiaorong Ding,2 Lanchun Liang,1 Yan Liu,2 Yongyan Wang,2

Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

 Qingsheng Shi,3 Tong Yang,4 Qingxiong Zhu,5 Yimei Tian,1 Cheng Lu,2 Zhiying Zhang,3 Zhongsheng Jiang,4 Hongying Zhou,3 Xiaofeng Wen,5 Huasheng Yang,1 Xiaorong Ding,2 Lanchun Liang,1 Yan Liu,2 Yongyan Wang,2

Triggering Apoptotic Death of Human Malignant Melanoma A375.S2 Cells by Bufalin: Involvement of Caspase Cascade-Dependent and Independent Mitochondrial Signaling Pathways

Yu,4 Chien-Chih Yu,4 Jai-Sing Yang,5 Jo-Hua Chiang,6 Chi-Cheng Lu,6 Hui-Ying Huang,7 Nou-Ying Tang,8 Jen-Hung Yang,9,10 An-Cheng Huang,11 and Jing-Gung Chung12,13 1Institute of Medicine, Chung Shan

Triggering Apoptotic Death of Human Malignant Melanoma A375.S2 Cells by Bufalin: Involvement of Caspase Cascade-Dependent and Independent Mitochondrial Signaling Pathways

-Shu Yu,4 Chien-Chih Yu,4 Jai-Sing Yang,5 Jo-Hua Chiang,6 Chi-Cheng Lu,6 Hui-Ying Huang,7 Nou-Ying Tang,8 Jen-Hung Yang,9,10 An-Cheng Huang,11 and Jing-Gung Chung12,13 1Institute of Medicine, Chung ... Pathways Yu-Ping Hsiao,1,2,3 Chun-Shu Yu,4 Chien-Chih Yu,4 Jai-Sing Yang,5 Jo-Hua Chiang,6 Chi-Cheng Lu,6 Hui-Ying Huang,7 Nou-Ying Tang,8 Jen-Hung Yang,9,10 An-Cheng Huang,11 and Jing-Gung Chung12,13

Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling by Emilia sonchifolia Extract, a Folklore Medicinal Plant

Medicinal Plant Yu-Hsuan Lan,1 Jo-Hua Chiang,2 Wen-Wen Huang,3 Chi-Cheng Lu,2 Jing-Gung Chung,3 Tian-Shung Wu,1 Jia-Hua Jhan,4 Kuei-Li Lin,5 Shu-Jen Pai,3 Yu-Jen Chiu,6 Minoru Tsuzuki,7,8 and Jai-Sing Yang8,9

Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 Cells In Vitro and Enhances Phagocytosis in Leukemia Mice In Vivo

Chen,4 Jai-Sing Yang,5 Fu-Shin Chueh,6 Chi-Cheng Lu,7 Jo-Hua Chiang,7 Wen-Wen Huang,8 Chia-Yu Ma,9 and Jing-Gung Chung8,10 1School of Chinese Medicine, China Medical University, Taichung 404, Taiwan