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Gene therapy for human glioblastoma using neurotropic JC virus-like particles as a gene delivery vector

journals • PubMed • Google Scholar Search for Cheng-Huang Shen in:Nature Research journals • PubMed • Google Scholar Search for Pei-Lain Chen in:Nature Research journals • PubMed • Google Scholar Search ... -Lain Chen and Cheng-Huang Shen helped with the literature search and gave advice for the study. Chien-Kuo Tai supplied materials. Deching Chang and Meilin Wang designed research. Competing Interests

Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells

-Lain Chen,4 Mien-Chun Lin,2,5 Cheng-Huang Shen,5 Chun-Nun Chao,6 Ming-Ko Chiang,2 Chiung-Yao Fang,7 and Deching Chang2 1Department of Chinese Medicine, Ditmanson Medical Foundation Chiayi Christian

Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells

The human polyomaviruses BK (BKPyV) and JC (JCPyV) are ubiquitous pathogens long associated with severe disease in immunocompromised individuals. BKPyV causes polyomavirus-associated nephropathy and hemorrhagic cystitis, whereas JCPyV is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy. No effective therapies targeting these...

Gene Therapy for Human Lung Adenocarcinoma Using a Suicide Gene Driven by a Lung-Specific Promoter Delivered by JC Virus-Like Particles

Lung adenocarcinoma, the most commonly diagnosed type of lung cancer, has a poor prognosis even with combined surgery, chemotherapy, or molecular targeted therapies. Most patients are diagnosed with an in-operable advanced or metastatic disease, both pointing to the necessity of developing effective therapies for lung adenocarcinoma. Surfactant protein B (SP-B) has been found to...

Gene Expression and DNA Methylation Status of Glutathione S-Transferase Mu1 and Mu5 in Urothelial Carcinoma

Bladder cancer is highly recurrent after therapy, which has an enormous impact on the health and financial condition of the patient. It is worth developing diagnostic tools for bladder cancer. In our previous study, we found that the bladder carcinogen BBN increased urothelial global DNA CpG methylation and decreased GSTM1 protein expression in mice. Here, the correlation of BBN...

Inhibition of human diffuse large B-cell lymphoma growth by JC polyomavirus-like particles delivering a suicide gene

Background Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of aggressive B-cell non-Hodgkin lymphoma. About one-third of patients are either refractory to the treatment or experience relapse afterwards, pointing to the necessity of developing other effective therapies for DLBCL. Human B-lymphocytes are susceptible to JC polyomavirus (JCPyV) infection, and...

Clinical Significance of Survivin Expression in Patients with Urothelial Carcinoma

Cheng-Huang Shen contributed equally to this work. Acknowledgments This study was supported by grants from the National Science Council, Taiwan (Grant no. NSC 101-2314-B-038-058), Chiayi Christian

Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer

Shen 7 Nan-Haw Chow 2 4 Hsiao-Sheng Liu 0 4 0 Department of microbiology and immunology, College of medicine, National Cheng Kung University , Tainan , Taiwan 1 Institute of Basic Medical Sciences

Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine

Cheng-Huang Shen Michael WY Chan 0 0 Department of Life Science, National Chung Cheng University , Min-Hsiung, Chia-Yi , Taiwan Background: Bladder cancer is the sixth most common cancer in the world and