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Melatonin plays critical role in mesenchymal stem cell-based regenerative medicine in vitro and in vivo

Although stem cells have emerged as promising sources for regenerative medicine, there are many potential safety hazards for their clinical application, including tumorigenicity, an availability shortage, senescence, and sensitivity to toxic environments. Mesenchymal stem cells (MSCs) have various advantages compared to other stem cells, including embryonic stem cells (ESCs) and...

Lipocalin 2: a potential therapeutic target for breast cancer metastasis

Lipocalin 2: a potential therapeutic target for breast cancer metastasis Chenxia Hu,1 Ke Yang,1 Mengjie Li,1 Weiping Huang,2 Fengxue Zhang,2 Hongqi Wang2 1School of Pharmaceutical Science, Guangzhou

Increasing vaccine production using pulsed ultrasound waves

inputs to improve the article. Author Contributions Conceptualization: Jie Chen. Funding acquisition: Jie Chen. Investigation: Jida Xing, Shrishti Singh, Yupeng Zhao, Yan Duan, Huining Guo, Chenxia Hu

In Vitro and In Vivo Hepatic Differentiation of Adult Somatic Stem Cells and Extraembryonic Stem Cells for Treating End Stage Liver Diseases

, Zhejiang ZJ 571, China Received 7 May 2015; Revised 17 June 2015; Accepted 13 July 2015 Academic Editor: Benedetta Bussolati Copyright © 2015 Chenxia Hu and Lanjuan Li. This is an open access article

Noninvasive in-vivo tracing and imaging of transplanted stem cells for liver regeneration

Terminal liver disease is a major cause of death globally. The only ultimate therapeutic approach is orthotopic liver transplant. Because of the innate defects of organ transplantation, stem cell-based therapy has emerged as an effective alternative, based on the capacity of stem cells for multilineage differentiation and their homing to injured sites. However, the disease...

In vitro culture of isolated primary hepatocytes and stem cell-derived hepatocyte-like cells for liver regeneration

cells for liver regeneration Chenxia Hu 0 Lanjuan Li 0 0 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious ... stem cellderived hepatocytes; PH, partial hepatectomy; SHs, small hepatocyte-like progenitor cells; TFs, transcription factors. COMPLIANCE WITH ETHICS GUIDELINES Chenxia Hu and Lanjuan Li declare that