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6 papers found.
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Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis

Background Ganglioside biosynthesis occurs through a multi-enzymatic pathway which at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides. In order to examine...

MRP3: a molecular target for human glioblastoma multiforme immunotherapy.

Background Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and validated a promising molecular therapeutic target that is expressed by GBM: human multidrug-resistance protein 3 (MRP3). Methods We investigated MRP3 by genetic...


TUMORS Bryan D. Choi, Chien-Tsun Kuan, Mingqing Cai, Darell D. Bigner, and John H. Sampson; Duke University Medical Center , Durham, NC, USA 6 The Second Hospital of Jilin University , Changchun, Changchun


, Chien-Tsun Kuan, Duane Mitchell, Darell Bigner, Hai Yan , and John Sampson; Duke University Medical Center , Durham, NC , USA 20 IT-015. LONG TERM REMISSION OVER 5 YEARS IN PATIENTS WITH NEWLY DIAGNOSED


Chandramohan, Chien-Tsun Kuan, Madan Kwatra, Hai Yan, and Darell Bigner; The Preston Robert Brain Tumor Center, Duke University, Durham, NC, USA INTRODUCTION: There is an urgent need for clinically relevant