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Post-radiation sinusitis is associated with recurrence in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy

This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT). Two hundred and thirty patients with non-metastatic NPC were analyzed in terms of freedom from local failure (FFLF), freedom from distant failure (FFDF), overall survival (OS), and disease-free...

Prognosis of Hippocampal Function after Sub-lethal Irradiation Brain Injury in Patients with Nasopharyngeal Carcinoma

journals • PubMed • Google Scholar Search for Chih-Jen Huang in:Nature Research journals • PubMed • Google Scholar Search for Tatsuhiro Hisatsune in:Nature Research journals • PubMed • Google Scholar ... interests. Corresponding authors Correspondence to Chih-Jen Huang or Tatsuhiro Hisatsune. Electronic supplementary material Supplementary Information Rights and permissions Open Access This article

HOW EXTERNAL CORPORATE GOVERNANCE AFFECTS SEOS PERFORMANCE: MEDIATING EFFECT OF AGENCY COSTS

In an analysis of moment structure (AMOS) setting, this study investigates the effectiveness of external corporate governance in mitigating agency costs and enhancing long-term operating performance for seasoned equity offerings (SEOs). Additionally, this study hypothesizes the crucial and mediating role of agency costs in the relationship between governance structure and post...

Neoadjuvant FOLFOX chemotherapy combined with radiotherapy followed by radical resection in patients with locally advanced colon cancer

Patients with locally advanced colon cancer (LACC) have a relatively poor prognosis despite radical resection and adjuvant chemotherapy. This study investigated the treatment efficacy and toxicity of neoadjuvant chemoradiotherapy in patients with LACC. We retrospectively reviewed 36 patients with LACC preoperatively treated with chemotherapy and radiotherapy. Patients were...

Using Stepwise Reality Check to Analyze Open-end Fund Investors’ Herding Redemption in Taiwan

-Lin Hsu Department of Applied Mathematics, National Chung Hsing University , Taiwan 3 Chih-Jen Huang Department of Finance, Providence University This study aims to examine whether funds with illiquid

Purchase and Redemption Decisions of Mutual Fund Investors of Variable Life Insurance-Using Quantile Regression

3 0 Department of risk Management and Insurance, Feng-Chia University 1 Nan-Yu Wang Department of Business and Tourism Planning, Ta Hwa University of Science and Technology 2 Chih-Jen Huang Department

Comparison of Long-Term Outcomes of Postmastectomy Radiotherapy between Breast Cancer Patients with and without Immediate Flap Reconstruction

Purpose To compare the long-term clinical outcomes of postmastectomy radiotherapy (PMRT) between breast cancer patients with and without immediate transverse rectus abdominis myocutaneous (TRAM) flap reconstruction. Methods The study included 492 patients with stage II or III breast cancer who underwent modified radical mastectomy (MRM) and chemotherapy followed by PMRT between...

The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways

The β-nitrostyrene family have been implicated for anti-cancer property. However, the pharmacological role of β-nitrostyrene in esophageal cancer remain unclear. Here, a β-nitrostyrene derivative, CYT-Rx20, was synthesized and assessed for its anti-cancer activities and underlying mechanism in esophageal cancer. CYT-Rx20 induced cytotoxicity in esophageal cancer cells by...

Feasibility and efficacy of helical tomotherapy in cirrhotic patients with unresectable hepatocellular carcinoma

Background This study is to evaluate the toxicity and outcomes of helical tomotherapy (HT) in patients treated for unresectable hepatocellular carcinoma (HCC). Methods From March 2008 to September 2010, 38 patients with unresectable HCC were treated with HT. The median patient age was 67 years (range, 45–85). The median follow-up period was 17.2 months (range, 7–46). All patients...

Feasibility and efficacy of helical tomotherapy in cirrhotic patients with unresectable hepatocellular carcinoma

This study is to evaluate the toxicity and outcomes of helical tomotherapy (HT) in patients treated for unresectable hepatocellular carcinoma (HCC). From March 2008 to September 2010, 38 patients with unresectable HCC were treated with HT. The median patient age was 67 years (range, 45–85). The median follow-up period was 17.2 months (range, 7–46). All patients had liver...

Patient- and therapy-related factors associated with the incidence of xerostomia in nasopharyngeal carcinoma patients receiving parotid-sparing helical tomotherapy

Hsiao-Yi Lee in:Nature Research journals • PubMed • Google ScholarSearch for Stephen Wan Leung in:Nature Research journals • PubMed • Google ScholarSearch for Chih-Jen Huang in:Nature Research journals ... . Corresponding authors Correspondence to Chih-Jen Huang or Pei-Ju Chao. Rights and permissions This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third

Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study

-Jen Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ... 11Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan Received 23 June 2015; Accepted 2 September 2015 Academic Editor: Janelle Wheat Copyright © 2015 Chih

Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study

-Jen Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ... 11Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan Received 23 June 2015; Accepted 2 September 2015 Academic Editor: Janelle Wheat Copyright © 2015 Chih

SNP 1772 C?>?T of HIF-1? gene associates with breast cancer risk in a Taiwanese population

Background Hypoxia inducible factor 1? (HIF-1?) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs) of HIF-1? gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1? activity. Results In this study, we focused on...

Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers

-Shiou F Yuan,8,9 Jing-Ru Liu,5 Qaisar Mansoor,1 Chih-Jen Huang,2,3,* Hsueh-Wei Chang5,9–11,*1Institute of Biomedical and Genetic Engineering (IBGE), KRL Hospital, Islamabad, Pakistan, 2Department of

Systematic screening of glycosylation- and trafficking-associated gene knockouts in Saccharomyces cerevisiae identifies mutants with improved heterologous exocellulase activity and host secretion

Background As a strong fermentator, Saccharomyces cerevisiae has the potential to be an excellent host for ethanol production by consolidated bioprocessing. For this purpose, it is necessary to transform cellulose genes into the yeast genome because it contains no cellulose genes. However, heterologous protein expression in S. cerevisiae often suffers from hyper-glycosylation and...

The Chicken Frizzle Feather Is Due to an α-Keratin (KRT75) Mutation That Causes a Defective Rachis

Feathers have complex forms and are an excellent model to study the development and evolution of morphologies. Existing chicken feather mutants are especially useful for identifying genetic determinants of feather formation. This study focused on the gene F, underlying the frizzle feather trait that has a characteristic curled feather rachis and barbs in domestic chickens. Our...

Roles of cis- and trans-Changes in the Regulatory Evolution of Genes in the Gluconeogenic Pathway in Yeast

The yeast Saccharomyces cerevisiae proliferates rapidly in glucose-containing media. As glucose is getting depleted, yeast cells enter the transition from fermentative to nonfermentative metabolism, known as the diauxic shift, which is associated with major changes in gene expression. To understand the expression evolution of genes involved in the diauxic shift and in...

Roles of Trans and Cis Variation in Yeast Intraspecies Evolution of Gene Expression

Both cis and trans mutations contribute to gene expression divergence within and between species. We used Saccharomyces cerevisiae as a model organism to estimate the relative contributions of cis and trans variations to the expression divergence between a laboratory (BY) and a wild (RM) strain of yeast. We examined whether genes regulated by a single transcription factor (TF...