Advanced search    

Search: authors:"Chiung-Chih Chang"

15 papers found.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Risk of dementia in patients with end-stage renal disease under maintenance dialysis—a nationwide population-based study with consideration of competing risk of mortality

BackgroundDementia is prevalent in the end-stage renal disease (ESRD) population. However, it is still not clarified whether ESRD is one of the etiology of dementia or its attributable effect on the cumulative risk of dementia. Meanwhile, the effect of competing risk of mortality should be taken into consideration when performing epidemiologic analyses among populations with high...

Development and validation of a dementia screening tool for primary care in Taiwan: Brain Health Test

this study. (XLSX) Author Contributions Conceptualization: Jian-Liang Liu, Ker-Neng Lin, Chiung-Chih Chang, Ming-Chyi Pai, Wen-Fu Wang, Jen-Ping Huang, Tzung-Jeng Hwang, Pei-Ning Wang. 11 / 14 Data ... curation: Ping-Huang Tsai, Jian-Liang Liu, Ker-Neng Lin, Chiung-Chih Chang, Ming Chyi Pai, Wen-Fu Wang, Jen-Ping Huang, Tzung-Jeng Hwang, Pei-Ning Wang. Formal analysis: Ping-Huang Tsai. Writing ± original

Associations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer’s disease

BackgroundAlzheimer’s disease (AD) is a complex neurodegenerative disease, and genetic differences may mediate neuronal degeneration. In humans, a single-nucleotide polymorphism in the B-cell chronic lymphocytic leukemia/lymphoma-2 (Bcl-2) gene, rs956572, has been found to significantly modulate Bcl-2 protein expression in the brain. The Bcl-2 AA genotype has been associated with...

Everyday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings

• PubMed • Google Scholar Search for Chiung-Chih Chang in:Nature Research journals • PubMed • Google Scholar Search for Kun-Ju Lin in:Nature Research journals • PubMed • Google Scholar Search for Ing ... , and manuscript drafting. Wen-Chuin Hsu, Chiung-Chih Chang, and Kun-Ju Lin contributed to administrative support in the hospital for the survey work, result interpretation, and manuscript preparation

Catechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer’s Disease

The catechol-O-methyltransferase enzyme metabolizes dopamine in the prefrontal axis, and its genetic polymorphism (rs4680; Val158Met) is a known determinant of dopamine signaling. In this study, we investigated the possible structural covariance networks that may be modulated by this functional polymorphism in patients with Alzheimer’s disease. Structural covariance networks were...

Genetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease

Background Inflammatory processes play a pivotal role in the degenerative process of Alzheimer’s disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 beta gene has been significantly associated with differences in the secretory capacity of interleukin-1 beta. In this study, we investigated whether this functional...

Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest

 Chiung-Chih Chang,1,2 Cheng-Hsien Lu,1,2 Nai-Ching Chen,1 Chi-Wei Huang,1,2 Wei-Che Lin,3 and Ya-Ting Chang1,2 1Department of Neurology, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan

Segmentation of the Striatum from MR Brain Images to Calculate the -TRODAT-1 Binding Ratio in SPECT Images

Quantification of regional -TRODAT-1 binding ratio in the striatum regions in SPECT images is essential for differential diagnosis between Alzheimer's and Parkinson's diseases. Defining the region of the striatum in the SPECT image is the first step toward success in the quantification of the TRODAT-1 binding ratio. However, because SPECT images reveal insufficient information...

Prefrontal Lobe Brain Reserve Capacity with Resistance to Higher Global Amyloid Load and White Matter Hyperintensity Burden in Mild Stage Alzheimer’s Disease

Background Amyloid deposition and white matter lesions (WMLs) in Alzheimer's disease (AD) are both considered clinically significant while a larger brain volume is thought to provide greater brain reserve (BR) against these pathological effects. This study identified the topography showing BR in patients with mild AD and explored the clinical balances among BR, amyloid, and WMLs...

Sweat output measurement of the post-ganglion sudomotor response by Q-Sweat Test: a normative database of Chinese individuals

AbstractBackgroundQ-Sweat is a model used for evaluating the post-ganglionic sudomotor function by assessing sweat response. This study aimed to establish the normative database of Q-Sweat test among Chinese individuals since this type of information is currently lacking.ResultsOne hundred and fifty (150) healthy volunteers, 76 men and 74 women with age range of 22–76 years were...

Clinical characteristics and prognosis of acute bacterial meningitis in elderly patients over 65: a hospital-based study

Background To examine the clinical characteristics of bacterial meningitis in elderly patients. Methods 261 patients with adult bacterial meningitis (ABM), collected during a study period of 11 years (2000-2010), were included for study. Among them, 87 patients aged ≥ 65 years and were classified as the elderly group. The clinical and laboratory characteristics and prognostic...

Clinical characteristics and therapeutic outcomes of nosocomial super-infection in adult bacterial meningitis

Background Super-infection in adult bacterial meningitis (ABM) is a condition wherein the cerebrospinal fluid (CSF) grows new pathogen(s) during the therapeutic course of meningitis. It is an uncommon but clinically important condition rarely examined in literature. Methods Twenty-seven episodes of super-infection states in 21 ABM patients collected in a 9.5-year study period...

Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy

Background Temporal lobe epilepsy (TLE) is a common form of focal epilepsy. Serum biomarkers to predict cognitive performance in TLE patients without psychiatric comorbidities and the link with gray matter (GM) atrophy have not been fully explored. Methods Thirty-four patients with TLE and 34 sex - and age-matched controls were enrolled for standardized cognitive tests...

Acute/subacute cerebral infarction (ASCI) in HIV-negative adults with cryptococcal meningoencephalitis (CM): a MRI-based follow-up study and a clinical comparison to HIV-negative CM adults without ASCI

Background Acute/subacute cerebral infarction (ASCI) in HIV-negative cryptococcal meningoencephalitis (CM) adults has rarely been examined by a series of MRI-based follow-up study. We studied a series of MRI follow-up study of CM adults and compared the clinical characters of those with ASCI and those without ASCI. Methods The clinical characteristics and a series of brain MRI...

Multi-parametric neuroimaging evaluation of cerebrotendinous xanthomatosis and its correlation with neuropsychological presentations

Background Cerebrotendinous xanthomatosis (CTX) is a rare genetic disorder. Recent studies show that brain damage in CTX patients extends beyond the abnormalities observed on conventional magnetic resonance imaging (MRI). We studied the MRI and 99 mTc-ethyl cysteinate dimer single photon emission computed tomography (SPECT) findings of CTX patients and made a correlation with the...